Publications by authors named "Philipp Ochtrop"

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TUB-040, a Homogeneous and Hydrophilic NaPi2b-Targeting ADC with Stably Linked Exatecan, Exhibits Long-lasting Antitumor Activity and a Well-Tolerated Safety Profile.
Annette M Vogl, Saskia Schmitt, Isabelle Mai, Paul Machui, Sarah Herterich, Philipp Ochtrop

Mol Cancer Ther· November 2025

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Effective eradication of acute myeloid leukemia stem cells with FLT3-directed antibody-drug conjugates.
Marina Able, Marc-André Kasper, Binje Vick, Jonathan Schwach, Xiang Gao, Philipp Ochtrop

Leukemia· March 2025

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Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody-Drug Conjugates.
Saskia Schmitt, Paul Machui, Isabelle Mai, Sarah Herterich, Swetlana Wunder, Philipp Ochtrop

Mol Cancer Ther· February 2024

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Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b.
Marietta S Kaspers, Vivian Pogenberg, Christian Pett, Stefan Ernst, Felix Ecker, Philipp Ochtrop

Nat Commun· April 2023

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Compact hydrophilic electrophiles enable highly efficacious high DAR ADCs with excellent PK profile.
Philipp Ochtrop, Jahaziel Jahzerah, Paul Machui, Isabelle Mai, Dominik Schumacher

Chem Sci· March 2023

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DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling.
Christian E Stieger, Yerin Park, Mark A R de Geus, Dongju Kim, Christiane Huhn, Philipp Ochtrop

Angew Chem Int Ed Engl· October 2022

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Modular solid-phase synthesis of electrophilic cysteine-selective ethynyl-phosphonamidate peptides.
Sarah Hansen, Jan Vincent V Arafiles, Philipp Ochtrop, Christian P R Hackenberger

Chem Commun (Camb)· July 2022

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Site-Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy.
Jonathan Schwach, Ksenia Kolobynina, Katharina Brandstetter, Marcus Gerlach, Philipp Ochtrop

Chembiochem· April 2021

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Recent advances of thiol-selective bioconjugation reactions.
Philipp Ochtrop, Christian Peter Richard Hackenberger

Curr Opin Chem Biol· October 2020

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effector AnkX displaces the switch II region for Rab1b phosphocholination.
Stefan Ernst, Felix Ecker, Marietta S Kaspers, Philipp Ochtrop, Christian Hedberg

Sci Adv· May 2020

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N-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates.
Marc-André Kasper, Marcus Gerlach, Anselm F L Schneider, Christiane Groneberg, Philipp Ochtrop

Chembiochem· January 2020

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Exploring the Substrate Scope of the Bacterial Phosphocholine Transferase AnkX for Versatile Protein Functionalization.
Philipp Ochtrop, Stefan Ernst, Aymelt Itzen, Christian Hedberg

Chembiochem· September 2019

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Ethynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates.
Marc-André Kasper, Andreas Stengl, Philipp Ochtrop, Marcus Gerlach, Tina Stoschek

Angew Chem Int Ed Engl· August 2019

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An amphipathic cyclic tetrapeptide scaffold containing halogenated β -amino acids with activity against multiresistant bacteria.
Marianne H Paulsen, Eskil André Karlsen, Dominik Ausbacher, Trude Anderssen, Annette Bayer, Philipp Ochtrop

J Pept Sci· October 2018

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Covalent Protein Labeling by Enzymatic Phosphocholination.
Katharina Heller, Philipp Ochtrop, Michael F Albers, Florian B Zauner, Aymelt Itzen

Angew Chem Int Ed Engl· August 2015

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