Publications by authors named "Philipp Rathert"

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An acidic patch in the unstructured N-terminus modulates LSD1 activity.
Franziska Dukatz, Hermann Timofeev, Philipp Schnee, Philipp Rathert

Protein Sci· December 2025

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Epigenomic profiling of immune cell subtypes reveals H3K27ac-marked stress signatures after long-duration spaceflight.
Tabea L Fullstone, Lukas F J Fischer, Maria Bohmeier, Petra Frings-Meuthen, Brian E Crucian, Philipp Rathert

Sci Rep· September 2025

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Identification of FLYWCH1 as a regulator of platinum-resistance in epithelial ovarian cancer.
Tabea L Fullstone, Helene Rohm, Till Kaltofen, Sophia Hierlmayer, Juliane Reichenbach, Philipp Rathert

NAR Cancer· June 2025

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CRISPR GENome and epigenome engineering improves loss-of-function genetic-screening approaches.
Jannis Stadager, Chiara Bernardini, Laura Hartmann, Henrik May, Jessica Wiepcke, Philipp Rathert

Cell Rep Methods· June 2025

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SETDB1 activity is globally directed by H3K14 acetylation via its Triple Tudor Domain.
Thyagarajan T Chandrasekaran, Michel Choudalakis, Alexander Bröhm, Sara Weirich, Alexandra G Kouroukli, Philipp Rathert

Nucleic Acids Res· December 2024

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The kinase NEK6 positively regulates LSD1 activity and accumulation in local chromatin sub-compartments.
Franziska Knodel, Jürgen Eirich, Sabine Pinter, Stephan A Eisler, Iris Finkemeier, Philipp Rathert

Commun Biol· November 2024

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Fluorescent Reporter Systems to Investigate Chromatin Effector Proteins in Living Cells.
Franziska Knodel, Sabine Pinter, Carolin Kroll, Philipp Rathert

Methods Mol Biol· July 2024

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Selenium nanoparticles modulate histone methylation via lysine methyltransferase activity and S-adenosylhomocysteine depletion.
Benoit Toubhans, Nour Alkafri, Marcos Quintela, David W James, Caroline Bissardon, Philipp Rathert

Redox Biol· May 2023

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G Protein-Coupled Estrogen Receptor Correlates With Dkk2 Expression and Has Prognostic Impact in Ovarian Cancer Patients.
Patricia Fraungruber, Till Kaltofen, Sabine Heublein, Christina Kuhn, Doris Mayr, Philipp Rathert

Front Endocrinol (Lausanne)· December 2021

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Inhibition of CBP synergizes with the RNA-dependent mechanisms of Azacitidine by limiting protein synthesis.
Jeannine Diesch, Marguerite-Marie Le Pannérer, René Winkler, Raquel Casquero, Matthias Muhar, Philipp Rathert

Nat Commun· October 2021

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Functional Analysis of Non-Genetic Resistance to Platinum in Epithelial Ovarian Cancer Reveals a Role for the MBD3-NuRD Complex in Resistance Development.
Tabea L Bauer, Katrin Collmar, Till Kaltofen, Ann-Katrin Loeffler, Lorena Decker, Philipp Rathert

Cancers (Basel)· July 2021

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Structure, Activity and Function of the NSD3 Protein Lysine Methyltransferase.
Philipp Rathert

Life (Basel)· July 2021

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A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation.
Sabine Pinter, Franziska Knodel, Michel Choudalakis, Philipp Schnee, Carolin Kroll, Philipp Rathert

Nucleic Acids Res· May 2021

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Genome-wide investigation of the dynamic changes of epigenome modifications after global DNA methylation editing.
Julian Broche, Goran Kungulovski, Pavel Bashtrykov, Philipp Rathert, Albert Jeltsch

Nucleic Acids Res· January 2021

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The GEF-H1/PKD3 signaling pathway promotes the maintenance of triple-negative breast cancer stem cells.
Wolfgang S Lieb, Cristiana Lungu, Raluca Tamas, Hannah Berreth, Philipp Rathert

Int J Cancer· June 2020

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Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns.
Max Emperle, Sabrina Adam, Stefan Kunert, Michael Dukatz, Annika Baude, Philipp Rathert

Nucleic Acids Res· December 2019

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Somatic Cancer Mutations in the SUV420H1 Protein Lysine Methyltransferase Modulate Its Catalytic Activity.
Alexander Bröhm, Hany Elsawy, Philipp Rathert, Srikanth Kudithipudi, Tabea Schoch

J Mol Biol· August 2019

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MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation.
Sara Sdelci, André F Rendeiro, Philipp Rathert, Wanhui You, Jung-Ming G Lin

Nat Genet· June 2019

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Stable Expression of Epigenome Editors via Viral Delivery and Genomic Integration.
Carolin Kroll, Philipp Rathert

Methods Mol Biol· February 2019

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Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2.
Arumugam Rajavelu, Cristiana Lungu, Max Emperle, Michael Dukatz, Alexander Bröhm, Philipp Rathert

Nucleic Acids Res· September 2018

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Modular fluorescence complementation sensors for live cell detection of epigenetic signals at endogenous genomic sites.
Cristiana Lungu, Sabine Pinter, Julian Broche, Philipp Rathert, Albert Jeltsch

Nat Commun· September 2017

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Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk.
Sara Sdelci, Charles-Hugues Lardeau, Cynthia Tallant, Freya Klepsch, Björn Klaiber, Philipp Rathert

Nat Chem Biol· July 2016

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The histone chaperone CAF-1 safeguards somatic cell identity.
Sihem Cheloufi, Ulrich Elling, Barbara Hopfgartner, Youngsook L Jung, Jernej Murn, Philipp Rathert

Nature· December 2015

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Transcriptional plasticity promotes primary and acquired resistance to BET inhibition.
Philipp Rathert, Mareike Roth, Tobias Neumann, Felix Muerdter, Jae-Seok Roe

Nature· September 2015

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Substrate specificity analysis and novel substrates of the protein lysine methyltransferase NSD1.
Srikanth Kudithipudi, Cristiana Lungu, Philipp Rathert, Nicole Happel, Albert Jeltsch

Chem Biol· February 2014

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