Publications by authors named "Philippe Bolduc"

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Accelerating Medicinal Chemistry: A C(sp)-Rich Fragment Toolbox for Redox-Neutral Cross-Coupling.
Jet Tsien, Áron Péter, Xin Zeng, Shuanghu Wang, Baiyang Jiang, Philippe N Bolduc

Angew Chem Int Ed Engl· December 2025

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Triply convergent Ni-electrocatalytic assembly of 1,1-diaryl cyclobutanes, azetidines and oxetanes.
Luca Massaro, Philipp Neigenfind, Andrew Feng, Gannon Kuehn, Flynn C Attard, Philippe N Bolduc

Nat Chem· November 2025

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-Cyclooctene Isomerization Catalyzed by Thiamine Degradation Products in Cell Culture Media.
Cathy A Muste, Thomas C Pickel, Philippe N Bolduc, Emily A Peterson, Chungang Gu

ACS Omega· June 2025

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PET imaging of antisense oligonucleotide distribution in rat and nonhuman primate brains using click chemistry.
Brendon E Cook, Thomas C Pickel, Sangram Nag, Philippe N Bolduc, Rouaa Beshr

Sci Transl Med· May 2025

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Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation.
Magnus Pfaffenbach, Philippe N Bolduc, Zhili Xin, Fang Gao, Ryan Evans

J Med Chem· May 2024

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A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors.
Philippe N Bolduc, Magnus Pfaffenbach, Ryan Evans, Zhili Xin, Kate L Henry

ACS Med Chem Lett· May 2024

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Carbon quaternization of redox active esters and olefins by decarboxylative coupling.
Xu-Cheng Gan, Benxiang Zhang, Nathan Dao, Cheng Bi, Maithili Pokle, Philippe N Bolduc

Science· April 2024

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Synthesis of Unnatural Amino Acids via Ni/Ag Electrocatalytic Cross-Coupling.
Gabriele Laudadio, Philipp Neigenfind, Rajesh Chebolu, Vanna D Blasczak, Shambabu Joseph Maddirala, Philippe N Bolduc

Org Lett· March 2024

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The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)--(6-methylpyrazolo[1,5-]pyrimidin-3-yl)imidazo[1,2-]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke.
Ryan Evans, Philippe N Bolduc, Magnus Pfaffenbach, Fang Gao, Tricia May-Dracka

J Med Chem· March 2024

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Nickel-Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers.
Gabriele Laudadio, Philipp Neigenfind, Áron Péter, Camille Z Rubel, Megan A Emmanuel, Philippe N Bolduc

Angew Chem Int Ed Engl· February 2024

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Complex molecule synthesis by electrocatalytic decarboxylative cross-coupling.
Benxiang Zhang, Jiayan He, Yang Gao, Laura Levy, Martins S Oderinde, Philippe N Bolduc

Nature· November 2023

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Overcoming Limitations in Decarboxylative Arylation via Ag-Ni Electrocatalysis.
Maximilian D Palkowitz, Gabriele Laudadio, Simon Kolb, Jin Choi, Martins S Oderinde, Philippe N Bolduc

J Am Chem Soc· September 2022

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Synthesis of N-Substituted 3-Amino-2-pyridones.
Philippe N Bolduc, Magnus Pfaffenbach, Vanna D Blasczak, Steven R Mathieu, Emily A Peterson

Org Lett· August 2022

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A small-molecule inhibitor of C5 complement protein.
Keith Jendza, Mitsunori Kato, Michael Salcius, Honnappa Srinivas, Andrea De Erkenez, Philippe Bolduc

Nat Chem Biol· July 2019

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The Discovery of ( S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma.
Takeru Ehara, Christopher M Adams, Doug Bevan, Nan Ji, Erik L Meredith, Philippe Bolduc

J Med Chem· March 2018

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Efficient macrocyclization achieved via conformational control using intermolecular noncovalent π-cation/arene interactions.
Philippe Bolduc, Alexandre Jacques, Shawn K Collins

J Am Chem Soc· September 2010

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