Publications by authors named "Philippe Gallay"

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Astodrimer sodium nasal spray forms a barrier to SARS-CoV-2 in vitro and preserves normal mucociliary function in human nasal epithelium.
Jeremy R A Paull, Carolyn A Luscombe, Aynaz Seta, Graham P Heery, Michael D Bobardt, Philippe A Gallay

Sci Rep· September 2024

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Cyclophilin inhibition as a strategy for the treatment of human disease.
Winston T Stauffer, Asha Z Goodman, Philippe A Gallay

Front Pharmacol· July 2024

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Cyclophilin D knockout significantly prevents HCC development in a streptozotocin-induced mouse model of diabetes-linked NASH.
Winston T Stauffer, Michael Bobardt, Daren R Ure, Robert T Foster, Philippe Gallay

PLoS One· April 2024

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Mice lacking cyclophilin B, but not cyclophilin A, are protected from the development of NASH in a diet and chemical-induced model.
Winston T Stauffer, Asha Z Goodman, Michael Bobardt, Daren R Ure, Robert T Foster, Philippe Gallay

PLoS One· March 2024

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The Cyclophilin Inhibitor Rencofilstat Decreases HCV-Induced Hepatocellular Carcinoma Independently of Its Antiviral Activity.
Winston Stauffer, Michael Bobardt, Daren Ure, Robert Foster, Philippe Gallay

Viruses· October 2023

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Post-infection treatment with the E protein inhibitor BIT225 reduces disease severity and increases survival of K18-hACE2 transgenic mice infected with a lethal dose of SARS-CoV-2.
Gary Ewart, Michael Bobardt, Bo Hjorth Bentzen, Yannan Yan, Audrey Thomson, Philippe Gallay

PLoS Pathog· August 2023

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The Cyclophilin Inhibitor Rencofilstat Decreases HCV-induced Hepatocellular Carcinoma Independently of Its Antiviral Activity.
Winston Stauffer, Michael Bobardt, Daren Ure, Robert Foster, Philippe Gallay

bioRxiv· August 2023

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Preclinical Considerations for Long-acting Delivery of Tenofovir Alafenamide from Subdermal Implants for HIV Pre-exposure Prophylaxis.
Manjula Gunawardana, Mariana Remedios-Chan, Debbie Sanchez, Rob Fanter, Simon Webster, Philippe A Gallay

Pharm Res· July 2023

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Acute antagonism in three-drug combinations for vaginal HIV prevention in humanized mice.
Philippe A Gallay, Christina M Ramirez, Marc M Baum

Sci Rep· March 2023

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Early SARS-CoV-2 dynamics and immune responses in unvaccinated participants of an intensely sampled longitudinal surveillance study.
Manjula Gunawardana, Simon Webster, Sofia Rivera, John M Cortez, Jessica Breslin, Philippe A Gallay

Commun Med (Lond)· October 2022

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Synergistic Effects of Sanglifehrin-Based Cyclophilin Inhibitor NV651 with Cisplatin in Hepatocellular Carcinoma.
Sonia Simón Serrano, Michele Tavecchio, Josef Mallik, Alvar Grönberg, Eskil Elmér, Philippe Gallay

Cancers (Basel)· September 2022

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Fundamental aspects of long-acting tenofovir alafenamide delivery from subdermal implants for HIV prophylaxis.
Manjula Gunawardana, Mariana Remedios-Chan, Debbie Sanchez, Simon Webster, Amalia E Castonguay, Philippe A Gallay

Sci Rep· May 2022

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The combination of the NS5A and cyclophilin inhibitors results in an additive anti-HCV inhibition in humanized mice without development of resistance.
Michael Bobardt, Christina M Ramirez, Marc M Baum, Daren Ure, Robert Foster, Philippe A Gallay

PLoS One· October 2021

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A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agents.
Thuc Nguyen Dan Do, Kim Donckers, Laura Vangeel, Arnab K Chatterjee, Philippe A Gallay

Antiviral Res· August 2021

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Protective Effects of Astodrimer Sodium 1% Nasal Spray Formulation against SARS-CoV-2 Nasal Challenge in K18-hACE2 Mice.
Jeremy R A Paull, Carolyn A Luscombe, Alex Castellarnau, Graham P Heery, Michael D Bobardt, Philippe A Gallay

Viruses· August 2021

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Virucidal and antiviral activity of astodrimer sodium against SARS-CoV-2 in vitro.
Jeremy R A Paull, Graham P Heery, Michael D Bobardt, Alex Castellarnau, Carolyn A Luscombe, Philippe A Gallay

Antiviral Res· July 2021

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Novel Cyclophilin Inhibitor Decreases Cell Proliferation and Tumor Growth in Models of Hepatocellular Carcinoma.
Sonia Simón Serrano, Michele Tavecchio, Alvar Grönberg, Wondossen Sime, Mohamed Jemaà, Philippe Gallay

Cancers (Basel)· June 2021

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Multispecies Evaluation of a Long-Acting Tenofovir Alafenamide Subdermal Implant for HIV Prophylaxis.
Manjula Gunawardana, Mariana Remedios-Chan, Debbie Sanchez, Simon Webster, Patricia Galvan, Philippe A Gallay

Front Pharmacol· November 2020

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Structurally distinct cyclosporin and sanglifehrin analogs CRV431 and NV556 suppress established HCV infection in humanized-liver mice.
Michael Bobardt, Magnus Joakim Hansson, Patrick Mayo, Daren Ure, Robert Foster, Philippe Gallay

PLoS One· October 2020

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Highly synergistic drug combination prevents vaginal HIV infection in humanized mice.
Marc M Baum, Christina M Ramirez, John A Moss, Manjula Gunawardana, Michael Bobardt, Philippe A Gallay

Sci Rep· August 2020

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The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice.
Michael Bobardt, Joseph Kuo, Udayan Chatterji, Norbert Wiedemann, Gregoire Vuagniaux, Philippe Gallay

PLoS One· April 2020

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The cyclophilin inhibitor CRV431 inhibits liver HBV DNA and HBsAg in transgenic mice.
Philippe Gallay, Daren Ure, Michael Bobardt, Udayan Chatterji, James Ou

PLoS One· March 2020

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A Pan-Cyclophilin Inhibitor, CRV431, Decreases Fibrosis and Tumor Development in Chronic Liver Disease Models.
Joseph Kuo, Michael Bobardt, Udayan Chatterji, Patrick R Mayo, Daniel J Trepanier, Philippe Gallay

J Pharmacol Exp Ther· November 2019

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Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis.
Sonia Simón Serrano, Alvar Grönberg, Lisa Longato, Krista Rombouts, Joseph Kuo, Philippe Gallay

Cells· November 2019

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Cyclophilin Inhibitor NV556 Reduces Fibrosis and Hepatocellular Carcinoma Development in Mice With Non-Alcoholic Steatohepatitis.
Joseph Kuo, Sonia Simón Serrano, Alvar Grönberg, Ramin Massoumi, Magnus Joakim Hansson, Philippe Gallay

Front Pharmacol· September 2019

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