Publications by authors named "Pierre Scotney"

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Vascular Endothelial Growth Factor-B Blockade with CSL346 in Diabetic Kidney Disease: A Phase 2A Randomized Controlled Trial.
Melisa Cooper, David Z I Cherney, Tom H Greene, Hiddo J L Heerspink, Meg Jardine, Pierre Scotney

J Am Soc Nephrol· November 2024

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Thrombolysis exacerbates cerebrovascular injury after ischemic stroke via a VEGF-B dependent effect on adipose lipolysis.
Ingrid Nilsson, Enming J Su, Linda Fredriksson, Benjamin Heller Sahlgren, Zsuzsa Bagoly, Pierre D Scotney

bioRxiv· October 2024

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Inhibition of VEGF-B signaling prevents non-alcoholic fatty liver disease development by targeting lipolysis in the white adipose tissue.
Annelie Falkevall, Annika Mehlem, Erika Folestad, Frank Chenfei Ning, Óscar Osorio-Conles, Pierre Scotney

J Hepatol· May 2023

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rIgG1 Fc Hexamer Inhibits Antibody-Mediated Autoimmune Disease via Effects on Complement and FcγRs.
Rolf Spirig, Ian K Campbell, Sandra Koernig, Chao-Guang Chen, Bonnie J B Lewis, Pierre Scotney

J Immunol· April 2018

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Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics.
Christian A Schaer, Catherine Owczarek, Jeremy W Deuel, Stefan Schauer, Jin Hyen Baek, Pierre D Scotney

BMC Biotechnol· March 2018

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An Anti-VEGF-B Antibody Fragment Induces Regression of Pre-Existing Blood Vessels in the Rat Cornea.
Yazad D Irani, Pierre D Scotney, Sonja Klebe, Lauren A Mortimer, Andrew D Nash

Invest Ophthalmol Vis Sci· July 2017

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An Optimized Hepatitis C Virus E2 Glycoprotein Core Adopts a Functional Homodimer That Efficiently Blocks Virus Entry.
Kathleen McCaffrey, Irene Boo, Catherine M Owczarek, Matthew P Hardy, Matthew A Perugini, Pierre Scotney

J Virol· March 2017

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Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease.
Annelie Falkevall, Annika Mehlem, Isolde Palombo, Benjamin Heller Sahlgren, Lwaki Ebarasi, Pierre Scotney

Cell Metab· March 2017

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A robust robotic high-throughput antibody purification platform.
Peter M Schmidt, Michael Abdo, Rebecca E Butcher, Min-Yin Yap, Pierre D Scotney

J Chromatogr A· July 2016

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Species Cross-Reactivity of Antibodies Used to Treat Ophthalmic Conditions.
Yazad Irani, Pierre Scotney, Andrew Nash, Keryn A Williams

Invest Ophthalmol Vis Sci· February 2016

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The combination of ISCOMATRIX adjuvant and TLR agonists induces regression of established solid tumors in vivo.
Anabel Silva, Adele Mount, Karoline Krstevska, David Pejoski, Matthew P Hardy, Pierre Scotney

J Immunol· March 2015

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Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody.
Sophie E Broughton, Timothy R Hercus, Matthew P Hardy, Barbara J McClure, Tracy L Nero, Pierre Scotney

Cell Rep· July 2014

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Identification of potent antagonist antibodies against mouse IL-13Rα1 using novel bioassays.
Kirsten M Edwards, Huy Huynh, Ranjeeta Prasad, Anne McDonald, Matthew P Hardy, Pierre Scotney

J Immunol Methods· May 2014

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Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362.
Sophie E Broughton, Timothy R Hercus, Tracy L Nero, Urmi Dhagat, Catherine M Owczarek, Pierre D Scotney

Acta Crystallogr F Struct Biol Commun· March 2014

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Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes.
Carolina E Hagberg, Annika Mehlem, Annelie Falkevall, Lars Muhl, Barbara C Fam, Pierre Scotney

Nature· October 2012

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VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis.
Fan Zhang, Zhongshu Tang, Xu Hou, Johan Lennartsson, Yang Li, Pierre Scotney

Proc Natl Acad Sci U S A· April 2009

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Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production.
Chun Geun Lee, Dominik Hartl, Hiroshi Matsuura, Felicity M Dunlop, Pierre D Scotney

Am J Respir Cell Mol Biol· December 2008

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Crystal structure of vascular endothelial growth factor-B in complex with a neutralising antibody Fab fragment.
Philip Leonard, Pierre D Scotney, Talat Jabeen, Shalini Iyer, Louis J Fabri

J Mol Biol· December 2008

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VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats.
Yang Li, Fan Zhang, Nobuo Nagai, Zhongshu Tang, Shuihua Zhang, Pierre Scotney

J Clin Invest· March 2008

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The biology of vascular endothelial growth factor-B (VEGF-B).
Andrew D Nash, Manuel Baca, Christine Wright, Pierre D Scotney

Pulm Pharmacol Ther· May 2006

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Crystal structure of human vascular endothelial growth factor-B: identification of amino acids important for receptor binding.
Shalini Iyer, Pierre D Scotney, Andrew D Nash, K Ravi Acharya

J Mol Biol· May 2006

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Transgenic overexpression of vascular endothelial growth factor-B isoforms by endothelial cells potentiates postnatal vessel growth in vivo and in vitro.
Arne W Mould, Sonia A Greco, Marian M Cahill, Ian D Tonks, Daniela Bellomo, Pierre Scotney

Circ Res· September 2005

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