Publications by authors named "Pim Gal"

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Microvascular effects of a mixed meal tolerance test: a model validation study.
Sebastiaan J W van Kraaij, Boukje Charlotte Eveleens Maarse, Femke P M Hoevenaars, Ines Warnke, Marieke L de Kam, Pim Gal

Clin Physiol Funct Imaging· January 2025

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High on-treatment platelet reactivity in peripheral arterial disease: A systematic review.
Lauren N Goncalves, Veerle van Velze, Frederikus A Klok, Pim Gal, Rimke C Vos

Vascular· December 2024

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Real-world overall survival after alternative dosing for pembrolizumab in the treatment of non-small cell lung cancer: A nationwide retrospective cohort study with a non-inferiority primary objective.
Geeske F Grit, Esmée van Geffen, Ruben Malmberg, Roelof van Leeuwen, Stefan Böhringer, Pim Gal

Lung Cancer· October 2024

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Open-Label Interventional Study in Healthy Volunteers to Evaluate NO-Mediated Vasodilation by Dermal Allyl Isothiocyanate Challenge and Whole-Body Heat Stress.
Marella C E van Ruissen, Sebastiaan J W van Kraaij, Pim Gal, Wouter A Bakker, Hemme J Hijma

J Exp Pharmacol· September 2024

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Impact of fibre supplementation on microbiome and resilience in healthy participants: A randomized, placebo-controlled clinical trial.
Boukje C Eveleens Maarse, Hannah M Eggink, Ines Warnke, Sabina Bijlsma, Tim J van den Broek, Pim Gal

Nutr Metab Cardiovasc Dis· June 2024

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A phase 1 trial of AP30663, a K2 channel inhibitor in development for conversion of atrial fibrillation.
Christina Yfanti, Birgitte Vestbjerg, Juliette Van't Westende, Nils Edvardsson, Laia Meseguer Monfort, Pim Gal

Br J Clin Pharmacol· April 2024

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Heart rate stability in a clinical setting and after a short exercise in healthy male volunteers.
Fleur W H Wildenbeest, Gert-Jan Hassing, Michiel J B Kemme, Matthijs Moerland, Pim Gal

Clin Physiol Funct Imaging· January 2024

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A Phase 1 randomized, open-label clinical trial to evaluate the effect of a far-infrared emitting patch on local skin perfusion, microcirculation and oxygenation.
Sebastiaan J W van Kraaij, Michael R Hamblin, Gisele Pickering, Bill Giannokopoulos, Hayet Kechemir, Pim Gal

Exp Dermatol· January 2024

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Randomized placebo-controlled crossover study to assess tolerability and pharmacodynamics of zagociguat, a soluble guanylyl cyclase stimulator, in healthy elderly.
Sebastiaan J W van Kraaij, Laura Borghans, Erica S Klaassen, Pim Gal, Jeroen van der Grond

Br J Clin Pharmacol· December 2023

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A smartphone- and wearable-based biomarker for the estimation of unipolar depression severity.
Ahnjili Zhuparris, Ghobad Maleki, Liesbeth van Londen, Ingrid Koopmans, Vincent Aalten, Pim Gal

Sci Rep· November 2023

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First-in-human trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of zagociguat (CY6463), a CNS-penetrant soluble guanylyl cyclase stimulator.
Sebastiaan J W van Kraaij, Pim Gal, Laura G J M Borghans, Erica S Klaassen, Francis Dijkstra

Clin Transl Sci· August 2023

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Characterization of the Pharmacokinetic and Pharmacodynamic Profile of Apraglutide, a Glucagon-Like Peptide-2 Analog, in Healthy Volunteers.
Federico Bolognani, Annelieke C Kruithof, Pascal Schulthess, Matthias Machacek, Marieke L de Kam, Pim Gal

J Pharmacol Exp Ther· August 2023

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Identification of peripheral vascular function measures and circulating biomarkers of mitochondrial function in patients with mitochondrial disease.
Sebastiaan J W van Kraaij, Diana R Pereira, Bastiaan Smal, Luciana Summo, Anne Konkel, Pim Gal

Clin Transl Sci· July 2023

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Vericiguat: A Randomized, Phase Ib, Placebo-Controlled, Double-Blind, QTc Interval Study in Patients with Chronic Coronary Syndromes.
Michael Böttcher, Hans-Dirk Düngen, Vasile Corcea, Frank Donath, Rainard Fuhr, Pim Gal

Am J Cardiovasc Drugs· March 2023

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Impact of oral administration of single strain spp. on immune responses to keyhole limpet hemocyanin immunization and gut microbiota: A randomized placebo-controlled trial in healthy volunteers.
Mahdi Saghari, Pim Gal, Hendrika W Grievink, Erica S Klaassen, Andrea Itano

Front Immunol· January 2023

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Dose escalations in phase I studies: Feasibility of interpreting blinded pharmacodynamic data.
Gerardus J Hassing, Michiel J van Esdonk, Gerard J P van Westen, Adam F Cohen, Jacobus Burggraaf, Pim Gal

Br J Clin Pharmacol· December 2022

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Cardiac age detected by machine learning applied to the surface ECG of healthy subjects: Creation of a benchmark.
Hein E C van der Wall, Gert-Jan Hassing, Robert-Jan Doll, Gerard J P van Westen, Adam F Cohen, Pim Gal

J Electrocardiol· June 2022

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OX40L Inhibition Suppresses KLH-driven Immune Responses in Healthy Volunteers: A Randomized Controlled Trial Demonstrating Proof-of-Pharmacology for KY1005.
Mahdi Saghari, Pim Gal, Sally Gilbert, Martin Yateman, Ben Porter-Brown

Clin Pharmacol Ther· May 2022

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Effect of hydroxychloroquine on the cardiac ventricular repolarization: A randomized clinical trial.
Boukje C Eveleens Maarse, Claus Graff, Jørgen K Kanters, Michiel J van Esdonk, Michiel J B Kemme, Pim Gal

Br J Clin Pharmacol· March 2022

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Detection of Clenbuterol-Induced Changes in Heart Rate Using At-Home Recorded Smartwatch Data: Randomized Controlled Trial.
Willem O Elzinga, Samantha Prins, Laura G J M Borghans, Pim Gal, Gabriel A Vargas

JMIR Form Res· December 2021

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A randomized controlled trial with a delayed-type hypersensitivity model using keyhole limpet haemocyanin to evaluate adaptive immune responses in man.
Mahdi Saghari, Pim Gal, Dimitrios Ziagkos, Jacobus Burggraaf, John F Powell

Br J Clin Pharmacol· April 2021

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The association between body temperature and electrocardiographic parameters in normothermic healthy volunteers.
Bart Fienieg, Gerardus J Hassing, Hein E C van der Wall, Gerard J P van Westen, Michiel J B Kemme, Pim Gal

Pacing Clin Electrophysiol· January 2021

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First Clinical Study with AP30663 - a K 2 Channel Inhibitor in Development for Conversion of Atrial Fibrillation.
Pim Gal, Erica S Klaassen, Kirsten R Bergmann, Mahdi Saghari, Jacobus Burggraaf

Clin Transl Sci· November 2020

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The Effect of a 13-Valent Conjugate Pneumococcal Vaccine on Circulating Antibodies Against Oxidized LDL and Phosphorylcholine in Man, A Randomized Placebo-Controlled Clinical Trial.
Hendrika W Grievink, Pim Gal, Maria Ozsvar Kozma, Erica S Klaassen, Johan Kuiper

Biology (Basel)· October 2020

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Additive effect of erythropoietin use on exercise-induced endothelial activation and hypercoagulability in athletes.
Jules A A C Heuberger, Jelle J Posthuma, Dimitrios Ziagkos, Joris I Rotmans, Johannes M A Daniels, Pim Gal

Eur J Appl Physiol· August 2020

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