Publications by authors named "Pin-Fang Lin"

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A survey of core replacements in indole-based HIV-1 attachment inhibitors.
Tao Wang, Owen B Wallace, Zhongxing Zhang, Haiquan Fang, Zhong Yang, Pin-Fang Lin, Milind Deshpande

Bioorg Med Chem Lett· June 2019

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Discovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and Its Phosphonooxymethyl Prodrug Fostemsavir.
Tao Wang, Yasu Ueda, Zhongxing Zhang, Zhiwei Yin, John Matiskella, Pin-Fang Lin

J Med Chem· July 2018

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Inhibitors of HIV-1 attachment: The discovery and structure-activity relationships of tetrahydroisoquinolines as replacements for the piperazine benzamide in the 3-glyoxylyl 6-azaindole pharmacophore.
Jacob J Swidorski, Zheng Liu, Zhiwei Yin, Tao Wang, David J Carini, Pin-Fang Lin

Bioorg Med Chem Lett· January 2016

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Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 12. Structure-activity relationships associated with 4-fluoro-6-azaindole derivatives leading to the identification of 1-(4-benzoylpiperazin-1-yl)-2-(4-fluoro-7-[1,2,3]triazol-1-yl-1h-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-585248).
Alicia Regueiro-Ren, Qiufen M Xue, Jacob J Swidorski, Yi-Fei Gong, Marina Mathew, Jacek Malinowski, Pin-Fang Lin

J Med Chem· February 2013

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Inhibitors of HIV-1 attachment. Part 10. The discovery and structure-activity relationships of 4-azaindole cores.
Tao Wang, Zhong Yang, Zhongxing Zhang, Yi-Fei Gong, Keith A Riccardi, Pin-Fang Lin

Bioorg Med Chem Lett· January 2013

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Inhibitors of HIV-1 attachment. Part 11: the discovery and structure-activity relationships associated with 4,6-diazaindole cores.
John A Bender, Zhong Yang, Betsy Eggers, Yi-Fei Gong, Pin-Fang Lin

Bioorg Med Chem Lett· January 2013

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In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068.
Beata Nowicka-Sans, Yi-Fei Gong, Brian McAuliffe, Ira Dicker, Hsu-Tso Ho, Pin-Fang Lin

Antimicrob Agents Chemother· July 2012

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Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 6. Preclinical and human pharmacokinetic profiling of BMS-663749, a phosphonooxymethyl prodrug of the HIV-1 attachment inhibitor 2-(4-benzoyl-1-piperazinyl)-1-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoethanone (BMS-488043).
John F Kadow, Yasutsugu Ueda, Nicholas A Meanwell, Timothy P Connolly, Tao Wang, Pin-Fang Lin

J Med Chem· March 2012

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In vivo patterns of resistance to the HIV attachment inhibitor BMS-488043.
Nannan Zhou, Beata Nowicka-Sans, Sharon Zhang, Li Fan, Jie Fang, Pin-Fang Lin

Antimicrob Agents Chemother· February 2011

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Increased sensitivity of HIV variants selected by attachment inhibitors to broadly neutralizing antibodies.
Nannan Zhou, Li Fan, Hsu-Tso Ho, Beata Nowicka-Sans, Yongnian Sun, Pin-Fang Lin

Virology· July 2010

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Protection against HIV-envelope-induced neuronal cell destruction by HIV attachment inhibitors.
Sharon Zhang, Louis Alexander, Tao Wang, Michele Agler, Nannon Zhou, Pin-Fang Lin

Arch Virol· May 2010

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Utilization of in vitro Caco-2 permeability and liver microsomal half-life screens in discovering BMS-488043, a novel HIV-1 attachment inhibitor with improved pharmacokinetic properties.
Zheng Yang, Lisa M Zadjura, Anthony M Marino, Celia J D'Arienzo, Jacek Malinowski, Pin-Fang Lin

J Pharm Sci· April 2010

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Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 5. An evolution from indole to azaindoles leading to the discovery of 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a drug candidate that demonstrates antiviral activity in HIV-1-infected subjects.
Tao Wang, Zhiwei Yin, Zhongxing Zhang, John A Bender, Zhong Yang, Pin-Fang Lin

J Med Chem· December 2009

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Inhibition of envelope-mediated CD4+-T-cell depletion by human immunodeficiency virus attachment inhibitors.
Louis Alexander, Sharon Zhang, Brian McAuliffe, David Connors, Nannon Zhou, Pin-Fang Lin

Antimicrob Agents Chemother· November 2009

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Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity.
Nicholas A Meanwell, Owen B Wallace, Henry Wang, Milind Deshpande, Bradley C Pearce, Pin-fang Lin

Bioorg Med Chem Lett· September 2009

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Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives.
Tao Wang, John F Kadow, Zhongxing Zhang, Zhiwei Yin, Qi Gao, Pin-Fang Lin

Bioorg Med Chem Lett· September 2009

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Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns.
Nicholas A Meanwell, Owen B Wallace, Haiquan Fang, Henry Wang, Milind Deshpande, Pin-Fang Lin

Bioorg Med Chem Lett· April 2009

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Entecavir exhibits inhibitory activity against human immunodeficiency virus under conditions of reduced viral challenge.
Pin-Fang Lin, Beata Nowicka-Sans, Brian Terry, Sharon Zhang, Chunfu Wang

Antimicrob Agents Chemother· May 2008

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X-ray crystal structures of human immunodeficiency virus type 1 protease mutants complexed with atazanavir.
Herbert E Klei, Kevin Kish, Pin-Fang M Lin, Qi Guo, Jacques Friborg

J Virol· September 2007

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Small-molecule HIV-1 gp120 inhibitors to prevent HIV-1 entry: an emerging opportunity for drug development.
John Kadow, Hwei-Gene Heidi Wang, Pin-Fang Lin

Curr Opin Investig Drugs· August 2006

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Envelope conformational changes induced by human immunodeficiency virus type 1 attachment inhibitors prevent CD4 binding and downstream entry events.
Hsu-Tso Ho, Li Fan, Beata Nowicka-Sans, Brian McAuliffe, Chang-Ben Li, Pin-Fang Lin

J Virol· April 2006

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Preclinical pharmacokinetics of a novel HIV-1 attachment inhibitor BMS-378806 and prediction of its human pharmacokinetics.
Zheng Yang, Lisa Zadjura, Celia D'Arienzo, Anthony Marino, Kenneth Santone, Pin-Fang Lin

Biopharm Drug Dispos· December 2005

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Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactions.
Qi Guo, Hsu-Tso Ho, Ira Dicker, Li Fan, Nannan Zhou, Pin-Fang Lin

J Virol· October 2003

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A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding.
Pin-Fang Lin, Wade Blair, Tao Wang, Timothy Spicer, Qi Guo, Gwendeline Demers

Proc Natl Acad Sci U S A· September 2003

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Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions.
Tao Wang, Zhongxing Zhang, Owen B Wallace, Milind Deshpande, Haiquan Fang, Pin-Fang Lin

J Med Chem· September 2003

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