Publications by authors named "Timothy Spicer"

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The Endo-GeneScreen platform identifies drug-like probes that regulate endogenous protein levels within physiological contexts.
Preston Samowitz, Laszlo Radnai, Thomas Vaissiere, Sheldon D Michaelson, Camilo Rojas, Timothy P Spicer

Nat Commun· December 2025

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High-throughput in vivo screening platform for rapid discovery of adult mosquitocides: Design, validation and automation for scalable vector control.
Sarah E McComic, Justin R Shumate, Jocelyn Peña, Timothy P Spicer, Louis Scampavia

Pestic Biochem Physiol· November 2025

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Discovery of a potent anti-Zika virus benzamide series targeting the viral protein NS4B.
Donghoon Chung, Yuka Otsuka, Eunjung Kim, Sultan Ullah, Nicole M Kennedy, Timothy P Spicer

bioRxiv· October 2025

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High throughput screening for SARS-CoV-2 inhibitors targeting 5 helix bundle.
Emery Smith, Qibin Geng, Justin Shumate, Yuka Otsuka, Louis Scampavia, Timothy P Spicer

SLAS Discov· September 2025

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Cell based high-throughput screening for small molecule inhibitors of ATE1.
Claudia McCown, Evan A Ambrose, Devang M Patel, Hassan Al-Ali, Louis Scampavia, Timothy P Spicer

SLAS Discov· September 2025

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Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor.
Xiaona Li, Nathan D Winters, Shubhi Pandey, Colten Lankford, Hannah M Stoveken, Timothy Spicer

Nat Commun· July 2025

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Hyperphosphorylated tau-based Alzheimer's Disease drug discovery: Identification of inhibitors of tau aggregation and cytotoxicity.
Hsiao-Tien Hagar, Virneliz Fernandez-Vega, Kuang-Wei Wang, Luis M Ortiz Jordan, Justin Shumate, Timothy P Spicer

SLAS Discov· June 2025

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Multimodal Treatment of a Peripheral Primitive Neuroectodermal Tumor Originating From the Thoracic Cavity in a Dog.
Leah H Ackerman, Madison Toonder, Sarah Bosch, Varvara B Semenova, Timothy P Spicer

J Vet Intern Med· May 2025

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SLAS special issue editorial 2025: Outcomes from antiviral drug discovery for pathogens of pandemic concern.
Timothy P Spicer, Louis D Scampavia

SLAS Discov· April 2025

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A high throughput assay for phosphoribosylformylglycinamidine synthase.
Nandini Sharma, Yuka Otsuka, Louis Scampavia, Timothy P Spicer, Jarrod B French

SLAS Discov· March 2025

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The Platform Identifies Drug-Like Probes that Regulate Endogenous Protein Levels within Physiological Contexts.
Preston Samowitz, Laszlo Radnai, Thomas Vaissiere, Sheldon D Michaelson, Camilo Rojas, Timothy P Spicer

bioRxiv· March 2025

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Target-based discovery of a broad-spectrum flukicide.
Daniel J Sprague, Sang-Kyu Park, Svenja Gramberg, Lisa Bauer, Claudia M Rohr, Timothy P Spicer

Nat Struct Mol Biol· September 2024

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Simultaneous screening for selective SARS-CoV-2, Lassa, and Machupo virus entry inhibitors.
Yuka Otsuka, Lizhou Zhang, Huihui Mou, Justin Shumate, Claire E Kitzmiller, Timothy P Spicer

SLAS Discov· September 2024

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SARS-CoV-2 M inhibitor identification using a cellular gain-of-signal assay for high-throughput screening.
Renee Delgado, Jyoti Vishwakarma, Seyed Arad Moghadasi, Yuka Otsuka, Justin Shumate, Timothy P Spicer

SLAS Discov· September 2024

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High throughput screening for SARS-CoV-2 helicase inhibitors.
Yuka Otsuka, Eunjung Kim, Austin Krueger, Justin Shumate, Chao Wang, Timothy P Spicer

SLAS Discov· September 2024

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A high-throughput cell-based screening method for Zika virus protease inhibitor discovery.
Paulina Duhita Anindita, Yuka Otsuka, Simon Lattmann, Khac Huy Ngo, Chong Wai Liew, Timothy P Spicer

SLAS Discov· July 2024

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Protocol for high throughput 3D drug screening of patient derived melanoma and renal cell carcinoma.
Luis M Ortiz Jordan, Virneliz Fernández Vega, Justin Shumate, Adam Peles, Jordan Zeiger, Timothy P Spicer

SLAS Discov· April 2024

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Protocol for kinetic mode potassium channel assays on common plate readers and microscopes.
Emery Smith, Louise Dickson, Philip Pickford, Anna Rowland, Justin Shumate, Timothy P Spicer

SLAS Discov· April 2024

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Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins.
Faisal Aziz, Kanamata Reddy, Virneliz Fernandez Vega, Raja Dey, Katherine A Hicks, Timothy P Spicer

J Med Chem· February 2024

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Neutral ceramidase-active site inhibitor chemotypes and binding modes.
Nicolas Coant, John D Bickel, Ronald Rahaim, Yuka Otsuka, Yong-Mi Choi, Timothy P Spicer

Bioorg Chem· October 2023

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A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer.
EunJung Lee, Suyakarn Archasappawat, Keely Ji, Jocelyn Pena, Virneliz Fernandez-Vega, Timothy P Spicer

Cell Death Dis· September 2023

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Target-based discovery of a broad spectrum flukicide.
Daniel J Sprague, Sang-Kyu Park, Svenja Gramberg, Lisa Bauer, Claudia M Rohr, Timothy P Spicer

bioRxiv· September 2023

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In Vitro and In Vivo Drug-Response Profiling Using Patient-Derived High-Grade Glioma.
Robin G Rajan, Virneliz Fernandez-Vega, Jantzen Sperry, Jonathan Nakashima, Long H Do, Timothy P Spicer

Cancers (Basel)· June 2023

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A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer.
EunJung Lee, Suyakarn Archasappawat, Keely Ji, Jocelyn Pena, Virneliz Fernandez-Vega, Timothy Spicer

bioRxiv· May 2023

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Elemene sensitizes pancreatic cancer cells to bortezomib by enhancing proteasome inhibition via molecular patch mechanism.
Shurong Hou, Zhenzhen Li, Xiaoling Chen, Wenxin Wang, Ting Duan, Timothy P Spicer

Signal Transduct Target Ther· February 2023

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