Publications by authors named "Po-Jen Chen"

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Coastal halophyte plant with previously undescribed terpenoids and anti-colorectal cancer chlorophyll stereoisomers utilizing a molecular networking approach.
Andrea Gu, Po-Jen Chen, Yih-Fung Chen, Ho-Cheng Wu, Tzong-Huei Lee

RSC Adv· November 2025

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Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis.
Shun-Hua Chen, Chun-Hong Chen, Hsin-Chieh Lin, Shyh-An Yeh, Tsong-Long Hwang, Po-Jen Chen

J Adv Res· June 2025

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Unlocking the potential of novel tetrahydro-β-carboline-based HDAC6 inhibitors for colorectal cancer therapy: Design, synthesis and biological evaluation.
Noreen Hemida, Dalia S El-Gamil, Ahmed K ElHady, Kai-Chun Lin, Yen-Hua Chang, Shun-Hua Chen, Chun-Hong Chen, Po-Jen Chen, Yi-Sheng Cheng

Bioorg Chem· June 2025

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Discovery of a novel C2-functionalized chromen-4-one scaffold for the development of p38α MAPK signaling inhibitors to mitigate neutrophilic inflammatory responses.
Yi-Han Chang, Yi-Chen Lee, Shun-Hua Chen, Shu-Yen Fang, Tzu-Peng Cheng, Po-Jen Chen

Biochem Pharmacol· May 2025

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Scutellaria barbata ameliorates acute respiratory distress syndrome by inhibiting neutrophil-mediated inflammatory responses.
Yu-Cheng Chen, Yao-Rong Lee, Yu-Chia Chang, Yi-Hsuan Wang, Shu-Yen Fang, Po-Jen Chen

J Ethnopharmacol· April 2025

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Development of potent and selective tetrahydro-β-carboline-based HDAC6 inhibitors with promising activity against triple-negative breast cancer.
Aya Fathy, Amro Allam, Ahmed K ElHady, Dalia S El-Gamil, Kai-Chun Lin, Shun-Hua Chen, Chun-Hong Chen, Po-Jen Chen, Yi-Sheng Cheng

RSC Med Chem· April 2025

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Guizhi Fuling Wan ameliorates concanavalin A-induced autoimmune hepatitis in mice.
Shun-Li Kuo, Chun-Han Su, Kuei-Hung Lai, Yu-Chia Chang, Jyh-Sheng You, Chun-Hong Chen, Chi-Chen Lin, Po-Jen Chen

Biomed J· February 2025

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Diterpenoid from as a Potential Radiation Sensitizer in Oral Squamous Cell Carcinoma: An In Vitro Study.
Hui-Ming Lee, Ping-Chung Kuo, Wen-Hui Chen, Po-Jen Chen, Sio-Hong Lam, Chih-Hao Chen

Int J Mol Sci· November 2024

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Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome.
Po-Jen Chen, Shun-Hua Chen, Yu-Li Chen, Yi-Hsuan Wang, Cheng-Yu Lin, Chun-Hong Chen

J Adv Res· August 2024

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Three-Month Excessive Body Weight Loss < 37.7% as a Predictor of Mid-term Suboptimal Outcomes Postlaparoscopic Sleeve Gastrectomy: Risk Factors and the Impact of Neutrophil-to-Lymphocyte Ratio on Adipocyte Function.
Jian-Han Chen, Po-Jui Chi, Chung-Yen Chen, Chi-Ming Tai, Po-Jen Chen

Obes Surg· July 2024

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Development of 5-hydroxybenzothiophene derivatives as multi-kinase inhibitors with potential anti-cancer activity.
Yara A Abd El-Rahman, Po-Jen Chen, Ahmed K ElHady, Shun-Hua Chen, Hsin-Chieh Lin

Future Med Chem· July 2024

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-Benzylated 5-Hydroxybenzothiophene-2-carboxamides as Multi-Targeted Clk/Dyrk Inhibitors and Potential Anticancer Agents.
Noha Mostafa, Po-Jen Chen, Sarah S Darwish, Yu-Chieh Su, Ming-Hua Shiao

Cancers (Basel)· May 2024

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Palbociclib blocks neutrophilic phosphatidylinositol 3-kinase activity to alleviate psoriasiform dermatitis.
Po-Jen Chen, Hsin-Hui Tseng, Yi-Hsuan Wang, Shu-Yen Fang, Shun-Hua Chen, Chun-Hong Chen

Br J Pharmacol· August 2023

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Perceived Stress Mediating the Association Between Mindfulness and Resilience Among Registered Nurses.
Shun-Hua Chen, Po-Jen Chen, Chiu-Hsiang Lee, Yu-Ping Wu, Daniel Kwasi Ahorsu

Psychol Res Behav Manag· August 2023

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Unlocking the Potential of Octocoral-Derived Secondary Metabolites against Neutrophilic Inflammatory Response.
Ngoc Bao An Nguyen, Mohamed El-Shazly, Po-Jen Chen, Bo-Rong Peng, Lo-Yun Chen

Mar Drugs· August 2023

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Carnosic acid inhibits reactive oxygen species-dependent neutrophil extracellular trap formation and ameliorates acute respiratory distress syndrome.
Yung-Fong Tsai, Shun-Chin Yang, Yun-Hsuan Hsu, Chun-Yu Chen, Po-Jen Chen

Life Sci· May 2023

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Hinokitiol Inhibits the Viability of Oral Squamous Carcinoma Cells by Inducing Apoptosis and Autophagy.
Hsin-Chieh Lin, Chih-Chun Wang, Ching-Fang Wu, Yuan-Ho Lin, Wei-Chang Lee, Po-Jen Chen

Anticancer Res· March 2023

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Sinulariaone A: a novel diterpenoid with a 13-membered carbocyclic skeleton from an octocoral species.
Hsuan-Jung Tseng, Liang-Mou Kuo, Yu-Chi Tsai, Hao-Chun Hu, Po-Jen Chen

RSC Adv· March 2023

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Chemometric-guided chemical marker selection: A case study of the heat-clearing herb .
Lung-Shuo Wang, Po-Jen Chen, Wen-Chi Cheng, Yu-Chia Chang, Mohamed El-Shazly, Lo-Yun Chen

Front Plant Sci· March 2023

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Discovery of novel 5-methoxybenzothiophene hydrazides as metabolically stable Clk1 inhibitors with high potency and unprecedented Clk1 isoenzyme selectivity.
Dalia S El-Gamil, Ahmed K ElHady, Po-Jen Chen, Tsong-Long Hwang, Ashraf H Abadi

Eur J Med Chem· February 2023

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MS/MS Molecular Networking Unveils the Chemical Diversity of Biscembranoid Derivatives, Neutrophilic Inflammatory Mediators from the Cultured Soft Coral .
Ngoc Bao An Nguyen, Lo-Yun Chen, Po-Jen Chen, Mohamed El-Shazly, Tsong-Long Hwang

Int J Mol Sci· December 2022

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Targeting PI3K/AKT/mTOR Signaling Pathway as a Radiosensitization in Head and Neck Squamous Cell Carcinomas.
Yu-Chieh Su, Wei-Chang Lee, Chih-Chun Wang, Shyh-An Yeh, Wen-Hui Chen, Po-Jen Chen

Int J Mol Sci· December 2022

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Lonicerae Japonicae Flos Attenuates Neutrophilic Inflammation by Inhibiting Oxidative Stress.
Kuei-Hung Lai, Yu-Li Chen, Mei-Fang Lin, Mohamed El-Shazly, Yu-Chia Chang, Po-Jen Chen, Chih-Chuan Chen, Lo-Yun Chen

Antioxidants (Basel)· September 2022

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The serial changes of Neutrophile-Lymphocyte Ratio and correlation to weight loss after Laparoscopic Sleeve Gastrectomy.
Po-Jui Chi, Kun-Ta Wu, Po-Jen Chen, Chung-Yen Chen, Yu-Chieh Su, Jian-Han Chen

Front Surg· September 2022

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5-Methoxytryptophan Sensitizing Head and Neck Squamous Carcinoma Cell to Cisplatitn Through Inhibiting Signal Transducer and Activator of Transcription 3 (STAT3).
Yu-Chieh Su, Chih-Chun Wang, Jui-Hsi Weng, Shyh-An Yeh, Po-Jen Chen, Huang-Chi Chen

Front Oncol· July 2022

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