Publications by authors named "Yu-Cheng Chen"

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Revisiting COX-2 inhibitors for Alzheimer's disease as multitargeted ligands: Development of 4-hydrazono-pyrazolidinediones with tuned COX selectivity profile and improved cellular potency.
Reham Waheed, Zeinab Mostafa, Michael Emad, Sarah S Darwish, Rosa Purgatorio, Tzu-Peng Cheng, Yu-Cheng Chen

Eur J Med Chem· January 2026

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Evolution of chromatographic modeling: From mechanistic models to hybrid models with physics-based deep learning.
Yu-Cheng Chen, Zhiyuan Chen, Shi-Peng Dai, Youping Xie, Shan-Jing Yao

J Chromatogr A· January 2026

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Evaluate the impact of PM in different macrophage types under the influence of seasonal changes and anthropogenic activities.
Yung-Jui Chen, Meng-Hsin Li, Fang-Yi Gu, Yu-Cheng Chen, Hong-Lin Chan

Biochimie· December 2025

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Seasonal and COVID-19 lockdown variations in PM composition to apoptosis pathways and chemical toxicity in lung cells.
Ting-Hsuan Wu, Yu-Cheng Chen, Hong-Lin Chan, Hsiu-Chuan Chou

Biochim Biophys Acta Gen Subj· December 2025

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Long-term air pollution exposure and mortality outcomes in colorectal cancer patients: Evidence from a multicenter longitudinal study.
Chih-Wen Wang, Pinpin Lin, Yu-Cheng Chen, Yueh-Hsia Luo, Chih-Da Wu

Cancer Epidemiol· December 2025

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Identification of a formyl peptide receptor 1 inhibitor through structure-based virtual screening.
Yi-Hsuan Wang, Tony Eight Lin, Yu-Cheng Chen, Kai-Cheng Hsu, Tsong-Long Hwang

Biochem Pharmacol· December 2025

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PanARGMiner (Pan-Genomic Antimicrobial Resistance Gene Miner): An advanced feature selection framework for extracting key resistance genes from pan-genomic datasets.
Yu-Cheng Chen, Ming-Ren Yang, Yu-Wei Wu

Comput Struct Biotechnol J· December 2025

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When FAPI Lights Up the Heart.
Chuan Huang, Yu-Cheng Chen

Eur Heart J Cardiovasc Imaging· November 2025

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Microlasers Integrated with Microfluidic Droplets for Exosome Profiling at the Single-Cell Level.
Tian Zhou, Guocheng Fang, Ningyuan Nie, Bowen Fu, Po-Hao Tseng, Yu-Cheng Chen

Anal Chem· November 2025

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Exploring pyrazolidinone and pyrazolidinedione scaffolds for Alzheimer's therapy: multitarget COX-2 inhibitors with anti-amyloid β, anti-tau, antioxidant, and neuroprotective activities.
Michael Emad, Reham Waheed, Zeinab Mostafa, Sarah S Darwish, Rosa Purgatorio, Tzu-Peng Cheng, Yu-Cheng Chen

RSC Med Chem· November 2025

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Assessing 3-D variability of ultrafine particle using a Geo-AI modelling approach: A case study in Zhunan-Miaoli, Taiwan.
Chia-Wei Hsu, Yinq-Rong Chern, Jun-Jun Su, Pei-Yi Wong, Aji Kusumaning Asri, Yu-Cheng Chen

Environ Pollut· October 2025

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Revealing the influence of solvent polarity and refractive index on whispering gallery mode-based laser sensors.
Jianwei Li, Dongyang Li, Guocheng Fang, Chengde Guo, Ningyuan Nie, Yu-Cheng Chen

Opt Express· October 2025

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The correlation of immunotoxicity with size and chemical properties of particulate matter within macrophages.
Hsiang-Yu Kung, Yi-Shiuan Wang, Yung-Jui Chen, Ting-Hsuan Wu, Jai-Yu Chen, Yu-Cheng Chen

Comp Biochem Physiol C Toxicol Pharmacol· September 2025

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Mechanistic modeling of retention time distribution under high breakthrough conditions for continuous Protein A affinity capture.
Wu-Wei Chen, Yan-Na Sun, Yu-Cheng Chen, Alois Jungbauer, Shan-Jing Yao

J Chromatogr A· September 2025

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Feature-based molecular networking of two Arenga species extracts, appraisal of their anti-inflammatory, analgesic, and antidiarrheal activity.
Wafaa A Ahmed, Amel M Kamal, Mohamed I S Abdelhady, Shimaa K Mohamed, Mohamed S Abdel-Aziz, Yu-Cheng Chen

Fitoterapia· September 2025

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Laser-emission vibrational microscopy of microdroplet arrays for high-throughput screening of hyperlipidemia.
Zhonghao Li, Zhihan Cai, Yuhan Wang, Yuliang Liu, Guifeng Li, Yu-Cheng Chen

Light Sci Appl· September 2025

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Hybrid Modeling of the Reversed-Phase Chromatographic Purification of an Oligonucleotide: Few-Shot Learning From Differentiable Physics Solver-in-the-Loop.
Yu-Cheng Chen, Ismaele Fioretti, Dong-Qiang Lin, Mattia Sponchioni

Biotechnol Bioeng· August 2025

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Laser-emitting aqueous bioreactors for ultrasensitive bioactivity analysis.
Guocheng Fang, Po-Hao Tseng, Jie Liao, Song Zhu, Tian Zhou, Yu-Cheng Chen

Proc Natl Acad Sci U S A· August 2025

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Application of machine learning algorithms to identify risk factors for depression in type 2 diabetes mellitus patients: A Taiwan diabetes registry study.
Yu-Wen Su, Wayne Huey-Herng Sheu, Chii-Min Hwu, Yu-Cheng Chen, Jung-Fu Chen, Harn-Shen Chen

J Chin Med Assoc· July 2025

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Deep Learning-Assisted Nanocavity Sensor for Amphiphilic Biomarker Analysis.
Bowen Fu, Zhiyi Yuan, Dong Yang, Zhongshu Xiong, Guocheng Fang, Yu-Cheng Chen

Anal Chem· July 2025

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Dielectric Nanocavity Enhanced Fluorescence Emission for Ultrasensitive Wavelength-Multiplexed Detection.
Bowen Fu, Zhiyi Yuan, Guocheng Fang, Wen-Jie Wang, Zhongshu Xiong, Yu-Cheng Chen

Nano Lett· June 2025

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Targeting Neutrophil-Mediated Inflammation: Identification of Pyrazolidinone Carboxamide Derivatives as Potent Selective Inhibitors of Formyl Peptide Receptor 1 (FPR1)-Activated Neutrophils.
Mohammad Abdel-Halim, Reem A Wagdy, Mohamed Salah, Yi-Hsuan Wang, Tzu-Peng Cheng, Yu-Cheng Chen

ACS Pharmacol Transl Sci· June 2025

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Preventive effects of Larazotide acetate (AT-1001) on non-alcoholic fatty liver diseases (NAFLD) in a mouse model.
Yu-Chen Huang, Jen-Shiu Chiang Chiau, Mei-Lein Cheng, Hung-Chang Lee, Wai-Tao Chan, Yu-Cheng Chen

Pediatr Neonatol· June 2025

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Inhibition of RPA32 and Cytotoxic Effects of the Carnivorous Plant Root Extract in Non-Small-Cell Lung Cancer Cells.
Kuo-Ting Chang, Yu-Cheng Chen, Yi Lien, Yen-Hua Huang, Cheng-Yang Huang

Plants (Basel)· May 2025

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Exosomes from human umbilical cord mesenchymal stem cells promote the growth of human hair dermal papilla cells.
Yu-Cheng Chen, Wei-Cheng Tsai, Zhi-Xiang Li, Wan-Jung Lin, Hao-Yu Lin, You-Yan Chen

PLoS One· April 2025

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