Publications by authors named "Tony Eight Lin"

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Butyrolactone I from Aspergillus fungi blocks neutrophil FPR1 to alleviate acute respiratory distress syndrome.
Chun-Yu Chen, Yu-Ting Kuo, Chih-Chuang Liaw, Yi-Hsuan Wang, Shih-Hsin Chang, Tony Eight Lin

Biochem Pharmacol· December 2025

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Exploring diarylheptanoid derivatives to target LIMK1 as potential agents against colorectal cancer.
Liang-Chieh Chen, Tung-Cheng Chang, Hui-Ju Tseng, Jung-Chun Chu, Yun-Yi Huang, Tony Eight Lin, Shiow-Lin Pan

J Enzyme Inhib Med Chem· December 2025

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Identification of a formyl peptide receptor 1 inhibitor through structure-based virtual screening.
Yi-Hsuan Wang, Tony Eight Lin, Yu-Cheng Chen, Kai-Cheng Hsu, Tsong-Long Hwang

Biochem Pharmacol· December 2025

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Consensus Pharmacological Interactions for PLK2 Inhibitor Identification in Colorectal Cancer Treatment.
Yi-Wen Wu, Chun-Lin Yang, Tony Eight Lin, Yun-Hsuan Yeh, Yu-Ting Fang-Chin, Shiow-Lin Pan

J Chem Inf Model· December 2025

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Establishment of an Integrated Model for Predicting Compound Mutagenicity with a Feature Importance Analysis.
Chao-Hsu Yang, Tony Eight Lin, Jui-Hua Hsieh, Kai-Cheng Hsu, Pei-Te Chiueh

J Chem Inf Model· November 2025

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Identification of pyrazole scaffold inhibitors targeting cyclin-dependent kinase 8 for potential use in pulmonary fibrosis.
Tony Eight Lin, Kai-Cheng Hsu, Ching-Hsuan Chou, En-Yun Tsai, Yi-Wen Wu, Shiow-Lin Pan

Biochem Pharmacol· July 2025

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Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure-Based Virtual Screening.
Chun-Lin Yang, Yi-Wen Wu, Huang-Ju Tu, Yun-Hsuan Yeh, Tony Eight Lin, Shiow-Lin Pan

Adv Sci (Weinh)· May 2025

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Structural optimization and biological evaluation of indolin-2-one derivatives as novel CDK8 inhibitors for idiopathic pulmonary fibrosis.
Jui-Yi Hsu, Kai-Cheng Hsu, Ching-Hsuan Chou, Tzu-Ying He, Tony Eight Lin

Biomed Pharmacother· March 2025

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Identification of a Potent CDK8 Inhibitor Using Structure-Based Virtual Screening.
Tony Eight Lin, Ching-Hsuan Chou, Yi-Wen Wu, Tzu-Ying Sung, Jui-Yi Hsu, Shiow-Lin Pan

J Chem Inf Model· January 2025

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The Cyclin-Dependent Kinase 8 Inhibitor E966-0530-45418 Attenuates Pulmonary Fibrosis and .
Ching-Hsuan Chou, Wei-Jan Huang, Kai-Cheng Hsu, Jui-Yi Hsu, Tony Eight Lin

Int J Biol Sci· January 2025

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Synthesis and biological evaluation of -phenyl phenylhydroxamic acids containing phenothiazine with improved selectivity for class IIa histone deacetylases.
Kai-Cheng Hsu, Yun-Yi Huang, Jung-Chun Chu, Yu-Wen Huang, Jing-Lan Hu, Tony Eight Lin

J Enzyme Inhib Med Chem· December 2024

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Identification, biological evaluation, and crystallographic analysis of coumestrol as a novel dual-specificity tyrosine-phosphorylation-regulated kinase 1A inhibitor.
Chao-Hsiang Peng, Tsong-Long Hwang, Shao-Chi Hung, Huang-Ju Tu, Yen-Tzu Tseng, Tony Eight Lin, Shiow-Lin Pan

Int J Biol Macromol· December 2024

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Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation.
Huang-Ju Tu, Min-Wu Chao, Cheng-Chung Lee, Chao-Shiang Peng, Yi-Wen Wu, Tony Eight Lin, Shiow-Lin Pan

J Enzyme Inhib Med Chem· December 2024

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Discovery of novel TANK-Binding Kinase 1 (TBK1) inhibitor against pancreatic ductal adenocarcinoma.
Wan-Hsi Shih, Han-Li Huang, Wei-Chun HuangFu, Tony Eight Lin, Tzu-Ying Sung, Guan-Lin Huang, Shiow-Lin Pan

Int J Biol Macromol· December 2024

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Discovery of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitors using an artificial intelligence model and their effects on tau and tubulin dynamics.
Jun-Hong Chen, Huang-Ju Tu, Tony Eight Lin, Zhao-Xiang Peng, Yi-Wen Wu, Shiow-Lin Pan

Biomed Pharmacother· December 2024

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HSP90/LSD1 dual inhibitors against prostate cancer as well as patient-derived colorectal organoids.
Di-Wei Tang, I-Chung Chen, Po-Yu Chou, Mei-Jung Lai, Zheng-Yang Liu, Tony Eight Lin

Eur J Med Chem· November 2024

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From Sea to Science: Coral Aquaculture for Sustainable Anticancer Drug Development.
Hung-Yu Lin, Tsen-Ni Tsai, Kai-Cheng Hsu, Yu-Ming Hsu, Lin-Chien Chiang, Yu-Hsuan Lin, Tony Eight Lin

Mar Drugs· July 2024

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In silico identification of a novel Cdc2-like kinase 2 (CLK2) inhibitor in triple negative breast cancer.
Cheng-Chiao Huang, Chia-Ming Hsu, Min-Wu Chao, Kai-Cheng Hsu, Tony Eight Lin, Shiow-Lin Pan

Protein Sci· June 2024

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An ensemble machine learning model generates a focused screening library for the identification of CDK8 inhibitors.
Tony Eight Lin, Dyan Yen, Wei-Chun HuangFu, Yi-Wen Wu, Jui-Yi Hsu, Shiow-Lin Pan

Protein Sci· June 2024

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A novel HDAC8 inhibitor H7E exerts retinoprotective effects against glaucomatous injury via ameliorating aberrant Müller glia activation and oxidative stress.
Liang-Huan Wu, Yu-Wen Cheng, Fan-Li Lin, Kai-Cheng Hsu, Mong-Heng Wang, Tony Eight Lin

Biomed Pharmacother· May 2024

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Identification of selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors and their effects on tau and microtubule.
Yi-Wen Wu, Wei-Chun HuangFu, Tony Eight Lin, Chao-Hsiang Peng, Huang-Ju Tu, Shiow-Lin Pan

Int J Biol Macromol· February 2024

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Synthesis and biological evaluation of C-4 substituted phenoxazine-bearing hydroxamic acids with potent class II histone deacetylase inhibitory activities.
Jung-Chun Chu, Hui-Ju Tseng, Sung-Bau Lee, Kai-Cheng Hsu, Ling-Wei Hsin, Tony Eight Lin

J Enzyme Inhib Med Chem· December 2023

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Synthesis and evaluation of potent (iso)ellipticine-based inhibitors of MYLK4 accessed expeditious synthesis from isoquinolin-5-ol.
Szu Lee, Min-Wu Chao, Yi-Wen Wu, Chia-Min Hsu, Tony Eight Lin, Shiow-Lin Pan

RSC Adv· October 2023

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Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma.
Hui-Ju Tseng, Suddhasatwa Banerjee, Bin Qian, Mei-Jung Lai, Tung-Yun Wu, Tony Eight Lin

Eur J Med Chem· August 2023

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Urolithin A exhibits a neuroprotective effect against Alzheimer's disease by inhibiting DYRK1A activity.
Huang-Ju Tu, Chih-Jou Su, Chao-Shiang Peng, Tony Eight Lin, Wei-Chun HuangFu, Shiow-Lin Pan

J Food Drug Anal· June 2023

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