Publications by authors named "RB Pearson"

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Exploiting dysregulated iron homeostasis to eradicate persistent high-grade serous ovarian cancer.
Carmelo Cerra, Madeleine R C Tancock, Niko Thio, Ada Koo, AnnRann Wong, Richard B Pearson

Cell Death Discov· September 2025

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ERG and c-MYC regulate a critical gene network in BCR::ABL1-driven B cell acute lymphoblastic leukemia.
Kira Behrens, Natalie Brajanovski, Zhen Xu, Elizabeth M Viney, Ladina DiRago, Richard B Pearson

Sci Adv· March 2024

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Targeting the ribosome to treat multiple myeloma.
Kylee H Maclachlan, Kezia Gitareja, Jian Kang, Andrew Cuddihy, Yuxi Cao, Richard B Pearson

Mol Ther Oncol· March 2024

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Spatial analysis with SPIAT and spaSim to characterize and simulate tissue microenvironments.
Yuzhou Feng, Tianpei Yang, John Zhu, Mabel Li, Maria Doyle, Richard B Pearson

Nat Commun· May 2023

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Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway.
Katherine M Hannan, Priscilla Soo, Mei S Wong, Justine K Lee, Nadine Hein, Richard B Pearson

Cell Rep· November 2022

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Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation.
Haoran Zhu, Keefe T Chan, Xinran Huang, Carmelo Cerra, Shaun Blake, Richard B Pearson

Elife· June 2022

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Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAF melanoma.
Lorey K Smith, Tiffany Parmenter, Margarete Kleinschmidt, Eric P Kusnadi, Jian Kang, Richard B Pearson

Nat Commun· March 2022

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CX-5461 Sensitizes DNA Damage Repair-proficient Castrate-resistant Prostate Cancer to PARP Inhibition.
Mitchell G Lawrence, Laura H Porter, Nicholas Choo, David Pook, Jeremy P Grummet, Richard B Pearson

Mol Cancer Ther· November 2021

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The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function.
Katarzyna Koltowska, Kazuhide S Okuda, Marleen Gloger, Maria Rondon-Galeano, Elizabeth Mason, Richard B Pearson

Nat Cell Biol· November 2021

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Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy.
Jian Kang, Natalie Brajanovski, Keefe T Chan, Jiachen Xuan, Richard B Pearson

Signal Transduct Target Ther· August 2021

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Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death.
Ana Domostegui, Suresh Peddigari, Carol A Mercer, Flavia Iannizzotto, Marta L Rodriguez, Richard B Pearson

Blood· June 2021

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The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer.
Shunfei Yan, Jiachen Xuan, Natalie Brajanovski, Madeleine R C Tancock, Piyush B Madhamshettiwar, Richard B Pearson

Br J Cancer· February 2021

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Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis.
Eric P Kusnadi, Anna S Trigos, Carleen Cullinane, David L Goode, Ola Larsson, Richard B Pearson

EMBO J· November 2020

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Suppression of ABCE1-Mediated mRNA Translation Limits N-MYC-Driven Cancer Progression.
Jixuan Gao, MoonSun Jung, Chelsea Mayoh, Pooja Venkat, Katherine M Hannan, Richard B Pearson

Cancer Res· September 2020

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CX-5461 can destabilize replication forks in PARP inhibitor-resistant models of ovarian cancer.
Jiachen Xuan, Richard B Pearson, Elaine Sanij

Mol Cell Oncol· August 2020

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rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461.
Jinbae Son, Katherine M Hannan, Gretchen Poortinga, Nadine Hein, Donald P Cameron, Richard B Pearson

Front Cell Dev Biol· July 2020

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CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer.
Elaine Sanij, Katherine M Hannan, Jiachen Xuan, Shunfei Yan, Jessica E Ahern, Richard B Pearson

Nat Commun· May 2020

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Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation.
Jeannine Diesch, Megan J Bywater, Elaine Sanij, Donald P Cameron, William Schierding, Richard B Pearson

Commun Biol· April 2020

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Oncogene-induced senescence: From biology to therapy.
Haoran Zhu, Shaun Blake, Frances K Kusuma, Richard B Pearson, Jian Kang

Mech Ageing Dev· April 2020

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A functional genetic screen defines the AKT-induced senescence signaling network.
Keefe T Chan, Shaun Blake, Haoran Zhu, Jian Kang, Anna S Trigos, Richard B Pearson

Cell Death Differ· February 2020

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Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma.
Shatha AbuHammad, Carleen Cullinane, Claire Martin, Zoe Bacolas, Teresa Ward, Richard B Pearson

Proc Natl Acad Sci U S A· September 2019

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Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload.
Chentao Ge, Hemiao Huang, Feiyan Huang, Tianxin Yang, Tengfei Zhang, Richard B Pearson

Proc Natl Acad Sci U S A· September 2019

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First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study.
Amit Khot, Natalie Brajanovski, Donald P Cameron, Nadine Hein, Kylee H Maclachlan, Richard B Pearson

Cancer Discov· August 2019

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Exploring Perspectives on Antimicrobial Use in Livestock: A Mixed-Methods Study of UK Pig Farmers.
Lucy A Coyne, Sophia M Latham, Susan Dawson, Ian J Donald, Richard B Pearson

Front Vet Sci· August 2019

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Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer.
Anna S Trigos, Richard B Pearson, Anthony T Papenfuss, David L Goode

Elife· February 2019

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