Publications by authors named "Rachel Botham"

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HaloTag as a substrate-based macroautophagy reporter.
Qiang Xiao, Gabrielle Cruz, Rachel Botham, Susan G Fox, Anan Yu

Proc Natl Acad Sci U S A· August 2024

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Optimizing human α-galactosidase for treatment of Fabry disease.
William C Hallows, Kristen Skvorak, Nick Agard, Nikki Kruse, Xiyun Zhang, Rachel C Botham

Sci Rep· March 2023

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Adapting protein sequences for optimized therapeutic efficacy.
Nikki Dellas, Joyce Liu, Rachel C Botham, Gjalt W Huisman

Curr Opin Chem Biol· October 2021

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Evaluation of a procaspase-3 activator with hydroxyurea or temozolomide against high-grade meningioma in cell culture and canine cancer patients.
Emily J Tonogai, Shan Huang, Rachel C Botham, Matthew R Berry, Stephen K Joslyn

Neuro Oncol· October 2021

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Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discovery.
Gabriel J Brighty, Rachel C Botham, Suhua Li, Luke Nelson, David E Mortenson

Nat Chem· October 2020

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Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients.
Avadhut D Joshi, Rachel C Botham, Lisa J Schlein, Howard S Roth, Antonella Mangraviti

Oncotarget· October 2017

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Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics.
Rachel C Botham, Howard S Roth, Alison P Book, Patrick J Roady, Timothy M Fan

ACS Cent Sci· August 2016

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A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed.
Rahul Palchaudhuri, Michael J Lambrecht, Rachel C Botham, Kathryn C Partlow, Tjakko J van Ham

Cell Rep· December 2015

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Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics.
Howard S Roth, Rachel C Botham, Steven C Schmid, Timothy M Fan, Levent Dirikolu

J Med Chem· May 2015

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Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity.
Rachel C Botham, Timothy M Fan, Isak Im, Luke B Borst, Levent Dirikolu

J Am Chem Soc· January 2014

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Parallel synthesis and biological evaluation of 837 analogues of procaspase-activating compound 1 (PAC-1).
Danny C Hsu, Howard S Roth, Diana C West, Rachel C Botham, Chris J Novotny

ACS Comb Sci· January 2012

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Preparation of the caspase-3/7 substrate Ac-DEVD-pNA by solution-phase peptide synthesis.
Quinn P Peterson, David R Goode, Diana C West, Rachel C Botham, Paul J Hergenrother

Nat Protoc· February 2010

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