Publications by authors named "Rachel Culp-Hill"

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Plasma lipid levels predict chemotherapy response and survival in acute myeloid leukemia.
Cristiana O'Brien, Nirvana Nursimulu, Anit Tyagi, Rachel Culp-Hill, Andrea Arruda

Blood· November 2025

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Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation.
Tianyi Ling, Cristiana O'Brien, Jonathan St-Germain, Vincent Rondeau, Mary Shi, Rachel Culp-Hill

Blood· November 2025

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Utilizing Serum-Derived Lipidomics with Protein Biomarkers and Machine Learning for Early Detection of Ovarian Cancer in the Symptomatic Population.
Brendan M Giles, Rachel Culp-Hill, Robert A Law, Charles M Nichols, Mattie Goldberg

Cancer Res Commun· September 2025

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Clinical Evaluation of a Multi-Omic Diagnostic Model for Early-Stage Ovarian Cancer Detection.
Robert A Law, Brendan M Giles, Rachel Culp-Hill, Enkhtuya Radnaa, Mattie Goldberg

Diagnostics (Basel)· September 2025

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Targeting pyruvate metabolism generates distinct CD8+ T cell responses to gammaherpesvirus and B lymphoma.
Taewook Kang, Young-Kwang Usherwood, Julie A Reisz, Sukrut C Kamerkar, Rachel Culp-Hill

JCI Insight· August 2025

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Lysosomal acid lipase A modulates leukemia stem cell response to venetoclax/tyrosine kinase inhibitor combination therapy in blast phase chronic myeloid leukemia.
Mohd Minhajuddin, Amanda Winters, Haobin Ye, Shanshan Pei, Brett Stevens, Rachel Culp-Hill

Haematologica· January 2025

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A distinct metabolic and epigenetic state drives trained immunity in HSC-derived macrophages from autoimmune mice.
Taylor S Mills, Bailee Kain, Matt A Burchill, Etienne Danis, Erin D Lucas, Rachel Culp-Hill

Cell Stem Cell· November 2024

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Cysteamine dioxygenase (ADO) governs cancer cell mitochondrial redox homeostasis through proline metabolism.
Sandy Che-Eun S Lee, Andrea Hye An Pyo, Helia Mohammadi, Ji Zhang, Anna Dvorkin-Gheva, Rachel Culp-Hill

Sci Adv· October 2024

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Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.
Vincent Rondeau, Jacob M Berman, Tianyi Ling, Cristiana O'Brien, Rachel Culp-Hill

Sci Transl Med· September 2024

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ACOD1 deficiency offers protection in a mouse model of diet-induced obesity by maintaining a healthy gut microbiota.
Tanja Eberhart, Federico Uchenna Stanley, Luisa Ricci, Tiziana Chirico, Roberto Ferrarese, Rachel Culp-Hill

Cell Death Dis· February 2024

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Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity.
Cristiana O'Brien, Tianyi Ling, Jacob M Berman, Rachel Culp-Hill, Julie A Reisz

Haematologica· September 2023

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Therapy-Resistant Acute Myeloid Leukemia Stem Cells Are Resensitized to Venetoclax + Azacitidine by Targeting Fatty Acid Desaturases 1 and 2.
Rachel Culp-Hill, Brett M Stevens, Courtney L Jones, Shanshan Pei, Monika Dzieciatkowska

Metabolites· March 2023

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Glutamine Metabolism Mediates Sensitivity to Respiratory Complex II Inhibition in Acute Myeloid Leukemia.
Alessia Roma, Matthew Tcheng, Nawaz Ahmed, Sarah Walker, Preethi Jayanth, Rachel Culp-Hill

Mol Cancer Res· November 2022

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Targeting Host Glycolysis as a Strategy for Antimalarial Development.
Andrew J Jezewski, Yu-Hsi Lin, Julie A Reisz, Rachel Culp-Hill, Yasaman Barekatain

Front Cell Infect Microbiol· October 2021

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Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity.
Angelo D'Alessandro, Xiaoyun Fu, Tamir Kanias, Julie A Reisz, Rachel Culp-Hill

Haematologica· May 2021

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Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance.
Emily L Giddings, Devin P Champagne, Meng-Han Wu, Joshua M Laffin, Tina M Thornton, Rachel Culp-Hill

Nat Commun· May 2021

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Extinguishing the Embers: Targeting AML Metabolism.
Rachel Culp-Hill, Angelo D'Alessandro, Eric M Pietras

Trends Mol Med· April 2021

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The Hepatic Microenvironment Uniquely Protects Leukemia Cells through Induction of Growth and Survival Pathways Mediated by LIPG.
Haobin Ye, Mohammad Minhajuddin, Anna Krug, Shanshan Pei, Chih-Hsing Chou, Rachel Culp-Hill

Cancer Discov· February 2021

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Fatty acid metabolism underlies venetoclax resistance in acute myeloid leukemia stem cells.
Brett M Stevens, Courtney L Jones, Daniel A Pollyea, Rachel Culp-Hill, Angelo D'Alessandro

Nat Cancer· December 2020

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Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells.
Courtney L Jones, Brett M Stevens, Daniel A Pollyea, Rachel Culp-Hill, Julie A Reisz

Cell Stem Cell· November 2020

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Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity.
Theresa L Montgomery, Axel Künstner, Josephine J Kennedy, Qian Fang, Lori Asarian, Rachel Culp-Hill

Proc Natl Acad Sci U S A· November 2020

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Transfusional iron overload and intravenous iron infusions modify the mouse gut microbiota similarly to dietary iron.
Francesca La Carpia, Boguslaw S Wojczyk, Medini K Annavajhala, Abdelhadi Rebbaa, Rachel Culp-Hill

NPJ Biofilms Microbiomes· June 2020

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Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis.
Hengbo Zhou, Melanie A Blevins, Jessica Y Hsu, Deguang Kong, Matthew D Galbraith, Rachel Culp-Hill

Cancer Res· June 2020

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Short-term interleukin-37 treatment improves vascular endothelial function, endurance exercise capacity, and whole-body glucose metabolism in old mice.
Dov B Ballak, Vienna E Brunt, Zachary J Sapinsley, Brian P Ziemba, James J Richey, Rachel Culp-Hill

Aging Cell· January 2020

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Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors.
Rani K Powers, Rachel Culp-Hill, Michael P Ludwig, Keith P Smith, Katherine A Waugh

Nat Commun· October 2019

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