Publications by authors named "Rajan Goel"

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Discovery of LNP1892: A Precision Calcimimetic for the Treatment of Secondary Hyperparathyroidism.
Manojkumar R Shukla, Gayathri Sadasivam, Ankush Sarde, Majid Sayyed, Vipul Pachpute, Rajan Goel

J Med Chem· July 2023

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Dual PI3Kδγ inhibition demonstrates potent anticancer effects in diffuse large B-cell lymphoma models: Discovery and preclinical characterization of LL-00084282.
Mahip K Verma, Charudatt Samant, Ramesh Kale, Sukanya Patra, Nilesh Mahajan, Rajan N Goel

Biochem Biophys Res Commun· December 2022

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LL-00066471, a novel positive allosteric modulator of α7 nicotinic acetylcholine receptor ameliorates cognitive and sensorimotor gating deficits in animal models: Discovery and preclinical characterization.
Mahip K Verma, Rajan N Goel, Anand M Bokare, Manoj P Dandekar, Sarita Koul

Eur J Pharmacol· January 2021

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Discovery of a Potent and Selective PI3Kδ Inhibitor ()-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4-quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models.
Manojkumar R Shukla, Sukanya Patra, Mahip Verma, Gayathri Sadasivam, Nirmal Jana, Rajan Goel

J Med Chem· December 2020

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Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization.
Neelima Sinha, Navnath P Karche, Mahip Kalyan Verma, Sameer S Walunj, Prashant B Nigade, Rajan N Goel

J Med Chem· February 2020

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Combination of APD668, a G protein-coupled receptor 119 agonist with linagliptin, a DPPIV inhibitor, prevents progression of steatohepatitis in a murine model of non-alcoholic steatohepatitis with diabetes.
Umakant Ashok Bahirat, Rashmi Talwar, Rekha Raghuveer Shenoy, Kumar V S Nemmani, Rajan Naresh Goel

Med Mol Morphol· March 2019

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Targeting glucose-dependent insulinotropic polypeptide receptor for neurodegenerative disorders.
Mahip K Verma, Rajan Goel, Nandakumar Krishnadas, Kumar V S Nemmani

Expert Opin Ther Targets· July 2018

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Bilateral quinolinic acid-induced lipid peroxidation, decreased striatal monoamine levels and neurobehavioral deficits are ameliorated by GIP receptor agonist D-AlaGIP in rat model of Huntington's disease.
Mahip K Verma, Rajan Goel, Krishnadas Nandakumar, Kumar V S Nemmani

Eur J Pharmacol· June 2018

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5-HT6 receptor agonist and antagonist modulates ICV-STZ-induced memory impairment in rats.
Anand M Bokare, Mandar Bhonde, Rajan Goel, Yogendra Nayak

Psychopharmacology (Berl)· May 2018

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Co-administration of APD668, a G protein-coupled receptor 119 agonist and linagliptin, a DPPIV inhibitor, prevents progression of steatohepatitis in mice fed on a high trans-fat diet.
Umakant Ashok Bahirat, Rekha Raghuveer Shenoy, Rashmi Talwar, Rajan Naresh Goel, Kumar V S Nemmani

Biochem Biophys Res Commun· January 2018

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Effect of D-AlaGIP, a stable GIP receptor agonist on MPTP-induced neuronal impairments in mice.
Mahip K Verma, Rajan Goel, Krishnadas Nandakumar, Kumar V S Nemmani

Eur J Pharmacol· June 2017

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5-HT6 Receptor Agonist and Antagonist Against β-Amyloid-Peptide-Induced Neurotoxicity in PC-12 Cells.
Anand M Bokare, A K Praveenkumar, Mandar Bhonde, Yogendra Nayak, Ravindra Pal, Rajan Goel

Neurochem Res· May 2017

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APD668, a G protein-coupled receptor 119 agonist improves fat tolerance and attenuates fatty liver in high-trans fat diet induced steatohepatitis model in C57BL/6 mice.
Umakant Ashok Bahirat, Rekha Raghuveer Shenoy, Rajan Naresh Goel, Kumar V S Nemmani

Eur J Pharmacol· April 2017

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