Publications by authors named "Rajkumar Dorajoo"

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Genomic platform specific polygenic risk scores impact breast cancer risk stratification.
Peh Joo Ho, Alexis Jiaying Khng, Joanna Hui Juan Tan, Pierre-Alexis Vincent Goy, Kayla Aisha Kamila, Rajkumar Dorajoo

Commun Med (Lond)· December 2025

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Interaction between dietary cholesterol intake and genetic variants for cholesterol absorption in relation to coronary artery disease mortality: a prospective analysis in the Singapore Chinese Health Study.
Shuxiao Shi, Xuling Chang, Rajkumar Dorajoo, Chiea Chuen Khor, Victor W Zhong

Am J Clin Nutr· November 2025

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Recruitment evaluation of a gerotherapeutic randomized controlled trial testing alpha-ketoglutarate in biologically older, middle-aged adults (ABLE).
Zhi Meng Lim, Yi Ern Chew, Lihuan Guan, Weilan Wang, Muhammad Daniel A Mahadzir, Rajkumar Dorajoo

Exp Gerontol· October 2025

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Polygenic prediction of body mass index and obesity through the life course and across ancestries.
Roelof A J Smit, Kaitlin H Wade, Qin Hui, Joshua D Arias, Xianyong Yin, Rajkumar Dorajoo

Nat Med· September 2025

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Predictive capabilities of polygenic scores in an East-Asian population-based cohort: the Singapore Chinese health study.
Xuling Chang, Chih Chuan Shih, Jieqi Chen, Ai Shan Lee, Patrick Tan, Rajkumar Dorajoo

Commun Biol· August 2025

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Systematic transcriptomics analysis of calorie restriction and rapamycin unveils their synergistic interaction in prolonging cellular lifespan.
Yizhong Zhang, Arshia Naaz, Trishia Yi Ning Cheng, Jovian Jing Lin, Mingtong Gao, Rajkumar Dorajoo

Commun Biol· May 2025

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DNAm age differences between infinium methylationEPICv1 vs EPICv2 in buffy coat, PBMC, and saliva samples.
Jian Hua Tay, Yi Ern Chew, Weilan Wang, Zhi Meng Lim, Lihuan Guan, Rajkumar Dorajoo

Commun Biol· April 2025

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Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations.
Xuling Chang, Zheng Li, Phan Vuong Khac Thai, Dang Thi Minh Ha, Nguyen Thuy Thuong Thuong, Rajkumar Dorajoo

medRxiv· April 2025

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Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline.
Yuqing Chen, Federico Torta, Hiromi W L Koh, Peter I Benke, Resham L Gurung, Rajkumar Dorajoo

Diabetologia· March 2025

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Genetic susceptibility of diffuse large B-cell lymphoma: a meta genome-wide association study in Asian population.
Qian Cui, Wen Tan, Bao Song, Rou-Jun Peng, Ling Wang, Rajkumar Dorajoo

Leukemia· March 2025

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The Association of Physical Function and Physical Performance With DNA Methylation Clocks in Oldest-Old Living in Singapore-The SG90 Cohort.
Jianhua Tay, Weilan Wang, Lihuan Guan, Rajkumar Dorajoo, Chiea-Chuen Khor

J Gerontol A Biol Sci Med Sci· March 2025

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Predictive Capabilities of Polygenic Scores in an East-Asian Population-based Cohort: The Singapore Chinese Health Study.
Xuling Chang, Chih Chuan Shih, Jieqi Chen, Ai Shan Lee, Patrick Tan, Rajkumar Dorajoo

medRxiv· February 2025

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The Causal Effect of Adult Height on Late-Life Handgrip Strength: The Singapore Chinese Health Study.
Xuling Chang, Kevin Yiqiang Chua, Chih Chuan Shih, Jieqi Chen, Ai Shan Lee, Rajkumar Dorajoo

J Gerontol A Biol Sci Med Sci· November 2024

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Curcumin Inhibits TORC1 and Prolongs the Lifespan of Cells with Mitochondrial Dysfunction.
Arshia Naaz, Yizhong Zhang, Nashrul Afiq Faidzinn, Sonia Yogasundaram, Rajkumar Dorajoo

Cells· September 2024

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Characterizing the Relationship between Expression Quantitative Trait Loci (eQTLs), DNA Methylation Quantitative Trait Loci (mQTLs), and Breast Cancer Risk Variants.
Peh Joo Ho, Alexis Khng, Benita Kiat-Tee Tan, Chiea Chuen Khor, Ern Yu Tan, Rajkumar Dorajoo

Cancers (Basel)· May 2024

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Novel Melanocortin-3 and -4 Receptor Functional Variants in Asian Children With Severe Obesity.
Siong Gim Ong, Roghayeh Dehghan, Rajkumar Dorajoo, Jian-Jun Liu, Andrew Anjian Sng

J Clin Endocrinol Metab· February 2024

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APOE Genotype Modifies the Association between Midlife Adherence to the Planetary Healthy Diet and Cognitive Function in Later Life among Chinese Adults in Singapore.
Ji-Juan Zhang, Yi-Xiang Ye, Rajkumar Dorajoo, Chiea-Chuen Khor, Xu-Ling Chang

J Nutr· January 2024

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Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.
Lisa de las Fuentes, Karen L Schwander, Michael R Brown, Amy R Bentley, Thomas W Winkler, Rajkumar Dorajoo

Front Genet· November 2023

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Alpha-ketoglutarate supplementation and BiologicaL agE in middle-aged adults (ABLE)-intervention study protocol.
Elena Sandalova, Jorming Goh, Zi Xiang Lim, Zhi Meng Lim, Diogo Barardo, Rajkumar Dorajoo

Geroscience· October 2023

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Disruption of Aldehyde Dehydrogenase 2 protects against bacterial infection.
Samuel B Berry, Scott Espich, Nguyen T T Thuong, Xuling Chang, Rajkumar Dorajoo

bioRxiv· August 2023

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Author Correction: The power of genetic diversity in genome-wide association studies of lipids.
Sarah E Graham, Shoa L Clarke, Kuan-Han H Wu, Stavroula Kanoni, Greg J M Zajac, Rajkumar Dorajoo

Nature· June 2023

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Increased BMI and late-life mobility dysfunction; overlap of genetic effects in brain regions.
Xuling Chang, Kevin Yiqiang Chua, Fang Lin Ng, Ling Wang, Jianjun Liu, Rajkumar Dorajoo

Int J Obes (Lond)· May 2023

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A five-safes approach to a secure and scalable genomics data repository.
Chih Chuan Shih, Jieqi Chen, Ai Shan Lee, Nicolas Bertin, Maxime Hebrard, Rajkumar Dorajoo

iScience· April 2023

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Polygenic risk scores for the prediction of common cancers in East Asians: A population-based prospective cohort study.
Peh Joo Ho, Iain BeeHuat Tan, Dawn Qingqing Chong, Chiea Chuen Khor, Jian-Min Yuan, Rajkumar Dorajoo

Elife· March 2023

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Vascular smooth muscle cells in low SYNTAX scores coronary artery disease exhibit proinflammatory transcripts and proteins correlated with IL1B activation.
Rajkumar Dorajoo, Mario Octavianus Ihsan, Wenting Liu, Hwee Ying Lim, Veronique Angeli

Atherosclerosis· January 2023

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