Publications by authors named "Ralph A Cacho"

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De novo design of proteins housing excitonically coupled chlorophyll special pairs.
Nathan M Ennist, Shunzhi Wang, Madison A Kennedy, Mariano Curti, George A Sutherland, Ralph A Cacho

Nat Chem Biol· July 2024

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Structural basis of nonribosomal peptide macrocyclization in fungi.
Jinru Zhang, Nicholas Liu, Ralph A Cacho, Zhou Gong, Zhu Liu

Nat Chem Biol· December 2016

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Reconstitution of Fungal Nonribosomal Peptide Synthetases in Yeast and In Vitro.
Ralph A Cacho, Yi Tang

Methods Mol Biol· October 2016

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Mechanism of the P450-Catalyzed Oxidative Cyclization in the Biosynthesis of Griseofulvin.
Jessica M Grandner, Ralph A Cacho, Yi Tang, K N Houk

ACS Catal· July 2016

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Understanding Programming of Fungal Iterative Polyketide Synthases: The Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase.
Ralph A Cacho, Justin Thuss, Wei Xu, Randy Sanichar, Zhizeng Gao

J Am Chem Soc· December 2015

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Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast.
Man-Cheng Tang, Hsiao-Ching Lin, Dehai Li, Yi Zou, Jian Li, Ralph A Cacho

J Am Chem Soc· November 2015

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Tandem prenyltransferases catalyze isoprenoid elongation and complexity generation in biosynthesis of quinolone alkaloids.
Yi Zou, Zhajun Zhan, Dehai Li, Mancheng Tang, Ralph A Cacho

J Am Chem Soc· April 2015

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Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi.
Ralph A Cacho, Yi Tang, Yit-Heng Chooi

Front Microbiol· February 2015

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Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans.
Wen-Bing Yin, Yit Heng Chooi, Adam R Smith, Ralph A Cacho, Youcai Hu

ACS Synth Biol· November 2013

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A cytochrome P450 serves as an unexpected terpene cyclase during fungal meroterpenoid biosynthesis.
Yit-Heng Chooi, Young J Hong, Ralph A Cacho, Dean J Tantillo, Yi Tang

J Am Chem Soc· November 2013

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Complexity generation in fungal polyketide biosynthesis: a spirocycle-forming P450 in the concise pathway to the antifungal drug griseofulvin.
Ralph A Cacho, Yit-Heng Chooi, Hui Zhou, Yi Tang

ACS Chem Biol· October 2013

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EcdGHK are three tailoring iron oxygenases for amino acid building blocks of the echinocandin scaffold.
Wei Jiang, Ralph A Cacho, Grace Chiou, Neil K Garg, Yi Tang

J Am Chem Soc· March 2013

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Bringing protein engineering and natural product biosynthesis together.
Ralph A Cacho, Yi Tang

Chem Biol· January 2013

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Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440.
Ralph A Cacho, Wei Jiang, Yit-Heng Chooi, Christopher T Walsh, Yi Tang

J Am Chem Soc· October 2012

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Protein engineering towards natural product synthesis and diversification.
Angelica O Zabala, Ralph A Cacho, Yi Tang

J Ind Microbiol Biotechnol· February 2012

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