Publications by authors named "Ralph A Defronzo"

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Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes.
John B Buse, Steven E Kahn, Vanita R Aroda, Richard J Auchus, Timothy Bailey, Irina Bancos, Robert S Busch, Elena A Christofides, Ralph A DeFronzo, Bradley Eilerman

Diabetes Care· December 2025

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Inadequately Controlled Type 2 Diabetes and Hypercortisolism: Improved Glycemia With Mifepristone Treatment.
Ralph A DeFronzo, Vivian Fonseca, Vanita R Aroda, Richard J Auchus, Timothy Bailey, Irina Bancos, Robert S Busch, John B Buse, Elena A Christofides, Bradley Eilerman

Diabetes Care· June 2025

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Cushing Syndrome, Hypercortisolism, and Glucose Homeostasis: A Review.
Ralph A DeFronzo, Richard J Auchus

Diabetes· December 2025

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Chronically elevated sympathetic nervous system tone: A significant, common, and poorly realised contributor to cardiometabolic disease in type 2 diabetes.
Ralph A DeFronzo

Diabetes Obes Metab· December 2025

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Differential Longitudinal Effects of Glucose-Lowering Medications on Glucagon and C-peptide Responses in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
Steven E Kahn, Mark Tripputi, John M Lachin, Ashok Balasubramanyam, Mary Ann Banerji, Ralph A DeFronzo

Diabetes Care· December 2025

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Impact of pulmonary hypertension on short and long-term outcome after mitral transcatheter edge-to-edge repair: A meta-analysis.
Sivaram Neppala, Himaja Dutt Chigurupati, Ayman Fath, Gowthami Sai Kogilathota Jagirdhar, Harigopal Sandhyavenu, Ralph A Defronzo

Cardiovasc Revasc Med· September 2025

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Changes in β-Cell Function and Insulin Sensitivity During Treatment With Dapagliflozin Alone or in Combination With Exenatide in Type 2 Diabetes.
Curtis Triplitt, Eugenio Cersosimo, Mariam Alatrach, John Adams, Andrea Hansis-Diarte, Ralph A DeFronzo

Diabetes Care· September 2025

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Empagliflozin Enhances Hepatic Glucose Production and Reduces Total-Body Norepinephrine Turnover Rate: A Randomized Trial.
Siham Abdelgani, Ahmed Khattab, John M Adams, Fahd Al-Mulla, Mohamed Abu-Farha, Ralph A DeFronzo

Diabetes· September 2025

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Impact of diabetes mellitus type-2 on the outcomes following mitral transcatheter edge-to-edge repair (TEER): A meta-analysis.
Himaja Dutt Chigurupati, Sivaram Neppala, Rahul Chikatimalla, Ayman Fath, Prakash Upreti, Ralph A DeFronzo

Am Heart J Plus· September 2025

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Early-Life Exposure to Organic Chemical Pollutants as Assessed in Primary Teeth and Cardiometabolic Risk in Mexican American Children: A Pilot Study.
Vidya S Farook, Feroz Akhtar, Rector Arya, Alice Yau, Srinivas Mummidi, Ralph A DeFronzo

Int J Environ Res Public Health· September 2025

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Mesenteric Visceral Lipectomy Improves Glucose Tolerance in Patients With Type 2 Diabetes: A Pilot Study.
Gozde Baskoy, Richard M Peterson, Jason Kempenich, Curtis Triplitt, Marissa Brown, Ralph A DeFronzo

J Clin Endocrinol Metab· August 2025

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One-Hour Plasma Glucose Predicts the Progression From Normal Glucose Tolerance to Prediabetes.
Muhammad Abdul-Ghani, Mohamed Abu-Farha, Tamam Abdul-Ghani, Alberto Chavez-Velazquez, Auora Merovci, Ralph A DeFronzo

Diabetes Care· July 2025

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Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries.
Alicia Huerta-Chagoya, Joohyun Kim, Ravi Mandla, Yingchang Lu, Ken Suzuki, Ralph A DeFronzo

medRxiv· July 2025

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Pre-Prediabetes: Insulin Resistance Is Associated With Cardiometabolic Risk in Nonobese Patients (STOP DIABETES).
John Armato, Ralph A DeFronzo, Muhammad Abdul-Ghani, Ron Ruby

J Clin Endocrinol Metab· April 2025

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Differential Treatment Effects on β-Cell Function Using Model-Based Parameters in Type 2 Diabetes: Results From the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
Kristina M Utzschneider, Mark Tripputi, Nicole M Butera, Andrea Mari, Samuel P Rosin, Ralph A DeFronzo

Diabetes Care· April 2025

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Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits.
Lauren E Petty, Hung-Hsin Chen, Elizabeth G Frankel, Wanying Zhu, Carolina G Downie, Ralph A DeFronzo

Nat Commun· April 2025

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Glycemic and non-glycemic benefits of initial triple therapy versus sequential add-on therapy in patients with new-onset diabetes: results from the EDICT study.
Muhammad Abdul-Ghani, Curtiss Puckett, Siham Abdelgani, Aurora Merovci, Olga Lavrynenko, Ralph A DeFronzo

BMJ Open Diabetes Res Care· April 2025

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Effect of dapagliflozin on renal haemodynamics in hyperfiltering T2D patients.
Eugenio Cersosimo, Qin YueJuan, Gozde Baskoy, Alberto Chavez, Maryam Barkhordarian, Ralph A DeFronzo

Diabetes Obes Metab· February 2025

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Effect of Hyperketonemia on Myocardial Function in Patients With Heart Failure and Type 2 Diabetes.
Carolina Solis-Herrera, Yuejuan Qin, Henri Honka, Eugenio Cersosimo, Curtis Triplitt, Ralph A DeFronzo

Diabetes· January 2025

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DCRM 2.0: Multispecialty practice recommendations for the management of diabetes, cardiorenal, and metabolic diseases.
Yehuda Handelsman, John E Anderson, George L Bakris, Christie M Ballantyne, Deepak L Bhatt, Ralph A DeFronzo

Metabolism· October 2024

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Effect of weight-maintaining ketogenic diet on glycemic control and insulin sensitivity in obese T2D subjects.
Aurora Merovci, Brittany Finley, Andrea Hansis-Diarte, Sivaram Neppala, Muhammad A Abdul-Ghani, Ralph A DeFronzo

BMJ Open Diabetes Res Care· October 2024

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Managing insulin resistance: the forgotten pathophysiological component of type 2 diabetes.
Muhammad Abdul-Ghani, Pietro Maffei, Ralph Anthony DeFronzo

Lancet Diabetes Endocrinol· September 2024

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Advances and counterpoints in type 2 diabetes. What is ready for translation into real-world practice, ahead of the guidelines.
Stanley S Schwartz, Barbara E Corkey, James R Gavin, Ralph A DeFronzo, Mary E Herman

BMC Med· September 2024

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Study protocol for a prospective, multicentre study of hypercortisolism in patients with difficult-to-control type 2 diabetes (CATALYST): prevalence and treatment with mifepristone.
Ralph A DeFronzo, Richard J Auchus, Irina Bancos, Lawrence Blonde, Robert S Busch

BMJ Open· July 2024

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Unexplained Residual Risk In Type 2 Diabetes: How Big Is The Problem?
Sivaram Neppala, Jemema Rajan, Eric Yang, Ralph A DeFronzo

Curr Cardiol Rep· June 2024

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