Publications by authors named "Ralph B Perkerson"

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Comparison of Culturing Methods of Primary Vaginal Fibroblasts.
Olivia O Cardenas-Trowers, Tammee M Parsons, Jing Zhao, Ralph B Perkerson, Christopher C Glembotski

Urogynecology (Phila)· November 2025

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Increased TMEM106B levels lead to lysosomal dysfunction which affects synaptic signaling and neuronal health.
Jolien Perneel, Miranda Lastra Osua, Sara Alidadiani, Nele Peeters, Linus De Witte, Ralph B Perkerson

Mol Neurodegener· April 2025

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Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice.
Xiaoye Ma, Dmitry Prokopenko, Ni Wang, Tomonori Aikawa, Younjung Choi, Ralph B Perkerson

Neurobiol Dis· March 2025

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Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer's disease.
Ni Wang, Yining Pan, Skylar C Starling, Devon H Haskell, Astrid C Quintero, Ralph B Perkerson

Alzheimers Dement· March 2025

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Human iPSC-Derived MSCs Induce Neurotrophic Effects and Improve Metabolic Activity in Acute Neuronal Injury Models.
Keiji Kawatani, Genesis Omana Suarez, Ralph B Perkerson, Ephraim E Parent, Toshihiko Nambara

J Neurosci· January 2025

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Secretome from iPSC-derived MSCs exerts proangiogenic and immunosuppressive effects to alleviate radiation-induced vascular endothelial cell damage.
Kshama Gupta, Ralph B Perkerson, Tammee M Parsons, Ramacharan Angom, Danilyn Amerna

Stem Cell Res Ther· July 2024

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ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism.
Keiji Kawatani, Marie-Louise Holm, Skylar C Starling, Yuka A Martens, Jing Zhao, Ralph B Perkerson

Mol Psychiatry· March 2024

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A mutant methionyl-tRNA synthetase-based toolkit to assess induced-mesenchymal stromal cell secretome in mixed-culture disease models.
Jeremy D Burgess, Danilyn Amerna, Emily S Norton, Tammee M Parsons, Ralph B Perkerson

Stem Cell Res Ther· October 2023

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A Mutant Methionyl-tRNA Synthetase-Based toolkit to assess induced-Mesenchymal Stromal Cell secretome in mixed-culture disease models.
Jeremy D Burgess, Danilyn Amerna, Emily S Norton, Tammee M Parsons, Ralph B Perkerson

Res Sq· May 2023

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LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4.
Hiroshi Oue, Yu Yamazaki, Wenhui Qiao, Chen Yuanxin, Yingxue Ren, Ralph B Perkerson

JCI Insight· April 2023

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Mesenchymal stem cell therapy for focal epilepsy: A systematic review of preclinical models and clinical studies.
Andres Ramos-Fresnedo, Carlos Perez-Vega, Ricardo A Domingo, Seung Jin Lee, Ralph B Perkerson

Epilepsia· July 2022

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Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits.
Rosa Rademakers, Alexandra M Nicholson, Yingxue Ren, Shunsuke Koga, Hung Phuoc Nguyen, Ralph B Perkerson

Brain Pathol· May 2021

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Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies.
Xiaolai Zhou, Alexandra M Nicholson, Yingxue Ren, Mieu Brooks, Peizhou Jiang, Ralph B Perkerson

Brain· June 2020

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Clinicopathologic correlations in a family with a mutation presenting as primary progressive aphasia and primary lateral sclerosis.
Veronica Hirsch-Reinshagen, Omar A Alfaify, Ging-Yuek R Hsiung, Cyril Pottier, Matt Baker, Ralph B Perkerson

Amyotroph Lateral Scler Frontotemporal Degener· November 2019

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Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.
Cyril Pottier, Yingxue Ren, Ralph B Perkerson, Matt Baker, Gregory D Jenkins

Acta Neuropathol· June 2019

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Pathological, imaging and genetic characteristics support the existence of distinct TDP-43 types in non-FTLD brains.
Keith A Josephs, Melissa E Murray, Nirubol Tosakulwong, Stephen D Weigand, Amanda M Serie, Ralph B Perkerson

Acta Neuropathol· February 2019

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Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.
Cyril Pottier, Xiaolai Zhou, Ralph B Perkerson, Matt Baker, Gregory D Jenkins

Lancet Neurol· June 2018

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Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity.
Alexandra M Nicholson, Xiaolai Zhou, Ralph B Perkerson, Tammee M Parsons, Jeannie Chew, Emilie Perkerson

Acta Neuropathol Commun· May 2018

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TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.
Ian R Mackenzie, Alexandra M Nicholson, Mohona Sarkar, James Messing, Maria D Purice, Ralph B Perkerson

Neuron· August 2017

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Prosaposin is a regulator of progranulin levels and oligomerization.
Alexandra M Nicholson, NiCole A Finch, Marcio Almeida, Ralph B Perkerson, Marka van Blitterswijk

Nat Commun· June 2016

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Dominant frontotemporal dementia mutations in 140 cases of primary progressive aphasia and speech apraxia.
Eoin P Flanagan, Matthew C Baker, Ralph B Perkerson, Joseph R Duffy, Edythe A Strand

Dement Geriatr Cogn Disord· October 2015

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Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS.
Mercedes Prudencio, Veronique V Belzil, Ranjan Batra, Christian A Ross, Tania F Gendron, Ralph B Perkerson

Nat Neurosci· August 2015

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Clinical and neuroimaging biomarkers of amyloid-negative logopenic primary progressive aphasia.
Jennifer L Whitwell, Joseph R Duffy, Edythe A Strand, Mary M Machulda, Matthew L Senjem, Ralph B Perkerson

Brain Lang· March 2015

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Progranulin-associated PiB-negative logopenic primary progressive aphasia.
Keith A Josephs, Joseph R Duffy, Edythe A Strand, Mary M Machulda, Prashanthi Vemuri, Ralph B Perkerson

J Neurol· March 2014

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TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia.
Alexandra M Nicholson, Nicole A Finch, Aleksandra Wojtas, Matt C Baker, Ralph B Perkerson

J Neurochem· September 2013

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