Publications by authors named "Ralph Minter"

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Targeted protein degradation using chimeric human E2 ubiquitin-conjugating enzymes.
Jonathan D Taylor, Nathalie Barrett, Sergio Martinez Cuesta, Katelyn Cassidy, Fiona Pachl, Ralph R Minter

Commun Biol· September 2024

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Characterization of mAbs against type 3 fimbriae isolated in a target-independent phage display campaign.
Sophia K Berry, Steven Rust, Lorraine Irving, Josefin Bartholdson Scott, Lucy A Weinert, Ralph Minter

Microbiol Spectr· August 2024

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Predictability of B cell clonal persistence and immunosurveillance in breast cancer.
Stephen-John Sammut, Jacob D Galson, Ralph Minter, Bo Sun, Suet-Feung Chin

Nat Immunol· May 2024

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Rapid discovery of high-affinity antibodies via massively parallel sequencing, ribosome display and affinity screening.
Benjamin T Porebski, Matthew Balmforth, Gareth Browne, Aidan Riley, Kiarash Jamali, Ralph Minter

Nat Biomed Eng· March 2024

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Gigavalent Display of Proteins on Monodisperse Polyacrylamide Hydrogels as a Versatile Modular Platform for Functional Assays and Protein Engineering.
Thomas Fryer, Joel David Rogers, Christopher Mellor, Timo N Kohler, Ralph Minter

ACS Cent Sci· August 2022

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Phenotypic whole-cell screening identifies a protective carbohydrate epitope on .
Sophia K Berry, Steven Rust, Carolina Caceres, Lorraine Irving, Josefin Bartholdson Scott, Ralph Minter

MAbs· March 2022

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Multiplexed Affinity Characterization of Protein Binders Directly from a Crude Cell Lysate by Covalent Capture on Suspension Bead Arrays.
Tuomas Huovinen, Laurens Lindenburg, Ralph Minter, Florian Hollfelder

Anal Chem· February 2021

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Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures.
Jacob D Galson, Sebastian Schaetzle, Rachael J M Bashford-Rogers, Matthew I J Raybould, Aleksandr Kovaltsuk, Ralph Minter

Front Immunol· January 2021

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In vitro evolution of antibody affinity via insertional scanning mutagenesis of an entire antibody variable region.
Kalliopi Skamaki, Stephane Emond, Matthieu Chodorge, John Andrews, D Gareth Rees, Ralph R Minter

Proc Natl Acad Sci U S A· November 2020

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A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies.
Olivia J S Macleod, Jean-Mathieu Bart, Paula MacGregor, Lori Peacock, Nicholas J Savill, Ralph Minter

Nat Commun· March 2020

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Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency.
Christina Schindler, Andie Collinson, Carl Matthews, Amy Pointon, Lesley Jenkinson, Ralph R Minter

PLoS One· December 2019

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Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion.
Camilla E Trevor, Andrea L Gonzalez-Munoz, Olivia J S Macleod, Peter G Woodcock, Steven Rust, Ralph Minter

Nat Microbiol· December 2019

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KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.
Nicolas Bery, Sandrine Legg, Judit Debreczeni, Jason Breed, Kevin Embrey, Ralph Minter

Nat Commun· June 2019

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A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis.
Paula MacGregor, Andrea L Gonzalez-Munoz, Fatoumatta Jobe, Martin C Taylor, Steven Rust, Ralph Minter

PLoS Negl Trop Dis· May 2019

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High affinity single-chain variable fragments are specific and versatile targeting motifs for extracellular vesicles.
Andrea Longatti, Christina Schindler, Andie Collinson, Lesley Jenkinson, Carl Matthews, Ralph Minter

Nanoscale· August 2018

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TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-κB pathway.
Jun Wang, Ricardo Ferreira, Wanhua Lu, Samatha Farrow, Kate Downes, Ralph Minter

Sci Rep· August 2018

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Correction: A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding.
Julie Douthwaite, Jacques Moisan, Cyril Privezentzev, Blagoje Soskic, Shereen Sabbah, Ralph R Minter

J Immunol· September 2017

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Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.
Sandrine Guillard, Paulina Kolasinska-Zwierz, Judit Debreczeni, Jason Breed, Jing Zhang, Ralph Minter

Nat Commun· July 2017

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Phenotypic screening-the fast track to novel antibody discovery.
Ralph R Minter, Alan M Sandercock, Steven J Rust

Drug Discov Today Technol· March 2017

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A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding.
Julie Douthwaite, Jacques Moisan, Cyril Privezentzev, Blagoje Soskic, Shereen Sabbah, Ralph R Minter

J Immunol· January 2017

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A Shorter Route to Antibody Binders via Quantitative in vitro Bead-Display Screening and Consensus Analysis.
Sylwia A Mankowska, Pietro Gatti-Lafranconi, Matthieu Chodorge, Sudharsan Sridharan, Ralph R Minter

Sci Rep· November 2016

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Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy.
Geoffrey S Williams, Bina Mistry, Sandrine Guillard, Jane Coates Ulrichsen, Alan M Sandercock, Ralph Minter

Oncotarget· October 2016

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Phenotypic screening: the future of antibody discovery.
Andrea L Gonzalez-Munoz, Ralph R Minter, Steven J Rust

Drug Discov Today· January 2016

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Combinatorial Screening Identifies Novel Promiscuous Matrix Metalloproteinase Activities that Lead to Inhibition of the Therapeutic Target IL-13.
Carole Urbach, Nathaniel C Gordon, Ian Strickland, David Lowne, Cathy Joberty-Candotti, Ralph R Minter

Chem Biol· November 2015

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Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling.
Alan M Sandercock, Steven Rust, Sandrine Guillard, Kris F Sachsenmeier, Nick Holoweckyj, Ralph Minter

Mol Cancer· July 2015

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