Publications by authors named "Ralph Mosley"

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Correction to Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase.
Michael J Sofia, Wonsuk Chang, Phillip A Furman, Ralph T Mosley, Bruce S Ross

J Med Chem· April 2017

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Molecular and structural basis for the roles of hepatitis C virus polymerase NS5B amino acids 15, 223, and 321 in viral replication and drug resistance.
Angela M Lam, Thomas E Edwards, Ralph T Mosley, Eisuke Murakami, Shalini Bansal

Antimicrob Agents Chemother· November 2014

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Use of 2'-spirocyclic ethers in HCV nucleoside design.
Jinfa Du, Byoung-Kwon Chun, Ralph T Mosley, Shalini Bansal, Haiying Bao

J Med Chem· March 2014

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Discovery of a novel class of potent HCV NS4B inhibitors: SAR studies on piperazinone derivatives.
Ramesh Kakarla, Jian Liu, Devan Naduthambi, Wonsuk Chang, Ralph T Mosley

J Med Chem· March 2014

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Structure of hepatitis C virus polymerase in complex with primer-template RNA.
Ralph T Mosley, Thomas E Edwards, Eisuke Murakami, Angela M Lam, Rena L Grice

J Virol· June 2012

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Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics.
Wonsuk Chang, Ralph T Mosley, Shalini Bansal, Meg Keilman, Angela M Lam

Bioorg Med Chem Lett· April 2012

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Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase.
Michael J Sofia, Wonsuk Chang, Phillip A Furman, Ralph T Mosley, Bruce S Ross

J Med Chem· March 2012

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Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor γ (PPARγ) modulators.
Weiguo Liu, Fiona Lau, Kun Liu, Harold B Wood, Gaochao Zhou, Ralph T Mosley

J Med Chem· December 2011

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Phenylpropenamide derivatives: anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs.
Peiyuan Wang, Devan Naduthambi, Ralph T Mosley, Congrong Niu, Phillip A Furman

Bioorg Med Chem Lett· August 2011

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Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates.
Eisuke Murakami, Haiying Bao, Ralph T Mosley, Jinfa Du, Michael J Sofia

J Med Chem· August 2011

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Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists.
Changyou Zhou, Cheng Tang, Eric Chang, Min Ge, Songnian Lin, Ralph Mosley

Bioorg Med Chem Lett· February 2010

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Molecular mechanism of action of pharmacoperone rescue of misrouted GPCR mutants: the GnRH receptor.
Jo Ann Janovick, Akshay Patny, Ralph Mosley, Mark T Goulet, Michael D Altman

Mol Endocrinol· February 2009

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Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice.
Carina P Tan, Yue Feng, Yun-Ping Zhou, George J Eiermann, Aleksandr Petrov, Ralph Mosley

Diabetes· August 2008

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What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases.
Jilly F Evans, Andrew D Ferguson, Ralph T Mosley, John H Hutchinson

Trends Pharmacol Sci· February 2008

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The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities.
Monica Einstein, Taro E Akiyama, Gino A Castriota, Chuanlin F Wang, Brian McKeever, Ralph T Mosley

Mol Pharmacol· January 2008

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Androstene-3,5-dienes as ER-beta selective SERMs.
Timothy A Blizzard, Candido Gude, Jerry D Morgan, Wanda Chan, Elizabeth T Birzin, Ralph T Mosley

Bioorg Med Chem Lett· November 2007

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The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors.
Christopher L Hamblett, Joey L Methot, Dawn M Mampreian, David L Sloman, Matthew G Stanton, Ralph T Mosley

Bioorg Med Chem Lett· October 2007

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Benzo[b]thiophene-based histone deacetylase inhibitors.
David J Witter, Sandro Belvedere, Liqiang Chen, J Paul Secrist, Ralph T Mosley

Bioorg Med Chem Lett· August 2007

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Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: synthesis, in vitro profile, molecular modeling studies, and in vivo experiments.
Christopher F Thompson, Nazia Quraishi, Amjad Ali, Ralph T Mosley, James R Tata

Bioorg Med Chem Lett· June 2007

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Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERalpha.
Kevin D Dykstra, Liangqin Guo, Elizabeth T Birzin, Wanda Chan, Yi Tien Yang, Ralph T Mosley

Bioorg Med Chem Lett· April 2007

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Identification of Leu276 of the S1P1 receptor and Phe263 of the S1P3 receptor in interaction with receptor specific agonists by molecular modeling, site-directed mutagenesis, and affinity studies.
Qiaolin Deng, Joseph A Clemas, Gary Chrebet, Paul Fischer, Jeffrey J Hale, Ralph Mosley

Mol Pharmacol· March 2007

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Sordarin derivatives induce a novel conformation of the yeast ribosome translocation factor eEF2.
Rikke Søe, Ralph T Mosley, Michael Justice, Jennifer Nielsen-Kahn, Mythili Shastry

J Biol Chem· January 2007

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Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands.
Kenneth J Wildonger, Ronald W Ratcliffe, Ralph T Mosley, Milton L Hammond, Elizabeth T Birzin

Bioorg Med Chem Lett· September 2006

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6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists.
Wanying Sun, Lovji D Cama, Elizabeth T Birzin, Sudha Warrier, Louis Locco, Ralph Mosley

Bioorg Med Chem Lett· March 2006

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Androstenediol analogs as ER-beta-selective SERMs.
Timothy A Blizzard, Candido Gude, Jerry D Morgan, Wanda Chan, Elizabeth T Birzin, Ralph T Mosley

Bioorg Med Chem Lett· February 2006

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