Publications by authors named "Ralph Woessner"

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Comprehensive Assessment of Pharmacokinetics, Pharmacodynamics, and Tolerability of Ligelizumab in Healthy Volunteers and Patients with Chronic Spontaneous Urticaria to Optimize Its Subcutaneous Delivery System.
Yan Ji, Claudio Calonder, Tiina Kirsilä, Alis Burciu, Matjaz Tisu, Ralph Woessner

Pharmaceutics· September 2023

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A Study to Evaluate Relative Bioavailability, Food Effect, and Pharmacodynamics of Tropifexor, a Farnesoid X Receptor Agonist, in Healthy Participants.
Rowan Stringer, Jin Chen, Bharti Shah, Jessie Gu, Yiming Zhang, Ralph Woessner

Clin Pharmacol Drug Dev· February 2023

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Drug-Drug Interaction Studies to Evaluate the Effect of Inhibition of UGT1A1 and CYP3A4 and Induction of CYP3A4 on the Pharmacokinetics of Tropifexor in Healthy Subjects.
Jin Chen, Rowan Stringer, Bharti Shah, Jessie Gu, Yiming Zhang, Ralph Woessner

Clin Pharmacol Drug Dev· November 2022

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Novel Bruton's tyrosine kinase inhibitor remibrutinib: Assessment of drug-drug interaction potential as a perpetrator of cytochrome P450 enzymes and drug transporters and the impact of covalent binding on possible drug interactions.
Hilmar Schiller, Felix Huth, Carole Schuhler, Anton Drollmann, Martin Kaul, Ralph Woessner

Eur J Pharm Sci· May 2022

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Pharmacokinetics of Tropifexor, a Potent Farnesoid X Receptor Agonist, in Participants With Varying Degrees of Hepatic Impairment.
Jin Chen, Jessie Gu, Bharti Shah, Rowan Stringer, Leonel Reis da Silva Torrao, Ralph Woessner

J Clin Pharmacol· April 2022

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Novel Bruton's Tyrosine Kinase inhibitor remibrutinib: Drug-drug interaction potential as a victim of CYP3A4 inhibitors based on clinical data and PBPK modeling.
Felix Huth, Hilmar Schiller, Yi Jin, Birk Poller, Carole Schuhler, Ralph Woessner

Clin Transl Sci· January 2022

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Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1-mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependence of Tropifexor Metabolism.
Lydia Wang-Lakshman, Zhuang Miao, Lai Wang, Helen Gu, Mark Kagan, Ralph Woessner

Drug Metab Dispos· July 2021

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Ligelizumab treatment for severe asthma: learnings from the clinical development programme.
Jordis Trischler, Ivan Bottoli, Reinhold Janocha, Christoph Heusser, Xavier Jaumont, Ralph Woessner

Clin Transl Immunology· March 2021

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Comparison of pharmacokinetics, safety and tolerability of secukinumab administered subcutaneously using different delivery systems in healthy volunteers and in psoriasis patients.
Gerard Bruin, Hans-Ulrich P Hockey, Phillip La Stella, Bárdur Sigurgeirsson, Rong Fu, Ralph Woessner

Br J Clin Pharmacol· February 2020

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Secukinumab Treatment Does Not Alter the Pharmacokinetics of the Cytochrome P450 3A4 Substrate Midazolam in Patients With Moderate to Severe Psoriasis.
Gerard Bruin, Anke Hasselberg, Irina Koroleva, Julie Milojevic, Claudio Calonder, Ralph Woessner

Clin Pharmacol Ther· December 2019

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Fevipiprant has a low risk of influencing co-medication pharmacokinetics: Impact on simvastatin and rosuvastatin in different SLCO1B1 genotypes.
Birk Poller, Ralph Woessner, Avantika Barve, Hanns-Christian Tillmann, Janardhana Vemula

Pulm Pharmacol Ther· August 2019

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CYP3A but not P-gp plays a relevant role in the in vivo intestinal and hepatic clearance of the delta-specific phosphoinositide-3 kinase inhibitor leniolisib.
Stefan De Buck, Klaus Kucher, Hisanori Hara, Cathy Gray, Ralph Woessner

Biopharm Drug Dispos· September 2018

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Absorption, Distribution, Metabolism, and Excretion of the Oral Prostaglandin D2 Receptor 2 Antagonist Fevipiprant (QAW039) in Healthy Volunteers and In Vitro.
David Pearson, H Markus Weiss, Yi Jin, Jan Jaap van Lier, Veit J Erpenbeck, Ralph Woessner

Drug Metab Dispos· July 2017

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Pharmacokinetics and safety of indacaterol and glycopyrronium (IND/GLY) following repeated once daily inhalation from a fixed-dose combination in healthy Chinese subjects
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Shuang Ren, Romain Sechaud, Zhenzhong Su, Hanns-Christian Tillmann, Hisanori Hara, Ralph Woessner

Int J Clin Pharmacol Ther· February 2017

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Intravenous Dosing as an Alternate Approach to Safely Achieve Supratherapeutic Exposure for Assessments of Cardiac Repolarization: A Randomized Clinical Trial with Mavoglurant (AFQ056).
Mike Ufer, Alexandros Sagkriotis, Atish Salunke, Subramanian Ganesan, Anne Tisserant, Ralph Woessner

Clin Ther· December 2016

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Pharmacokinetics of indacaterol and mometasone furoate delivered alone or in a free or fixed dose combination in healthy subjects.
Soniya S Vaidya, Sanjeev Khindri, Nicole Calder, Surendra Machineni, Hisanori Hara, Ralph Woessner

Pulm Pharmacol Ther· April 2016

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Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion.
Christian Dragatin, Florine Polus, Manfred Bodenlenz, Claudio Calonder, Birgit Aigner, Ralph Woessner

Exp Dermatol· February 2016

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Effect of mavoglurant (AFQ056), a selective mGluR5 antagonist, on the pharmacokinetics of a combined oral contraceptive containing ethinyl estradiol and levonorgestrel in healthy women.
Rama Sivasubramanian, Abhijit Chakraborty, Marie-Laure Rouzade-Dominguez, Srikanth Neelakantham, Annamaria Jakab, Ralph Woessner

Int J Clin Pharmacol Ther· July 2015

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Single- and multiple-dose pharmacokinetics of inhaled indacaterol in healthy Chinese volunteers.
Ji Jiang, Lilly Li, Hequn Yin, Ralph Woessner, Corinne Emotte

Eur J Drug Metab Pharmacokinet· June 2015

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Model-based evaluation of the impact of formulation and food intake on the complex oral absorption of mavoglurant in healthy subjects.
Thierry Wendling, Kayode Ogungbenro, Etienne Pigeolet, Swati Dumitras, Ralph Woessner

Pharm Res· May 2015

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Pharmacokinetics of QMF149 in Japanese versus Caucasian subjects: an open-label, randomized phase I study.
Sayaka Shimada, Soniya Vaidya, Sanjeev Khindri, Natsuka Tashiro, Yi Cheng, Ralph Woessner

Int J Clin Pharmacol Ther· May 2015

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Metabolism and disposition of the metabotropic glutamate receptor 5 antagonist (mGluR5) mavoglurant (AFQ056) in healthy subjects.
Markus Walles, Thierry Wolf, Yi Jin, Michael Ritzau, Luc Alexis Leuthold, Ralph Woessner

Drug Metab Dispos· September 2013

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Validation of an LC-MS/MS method for the quantitative determination of mavoglurant (AFQ056) in human plasma.
Annamaria Jakab, Serge Winter, Marc Raccuglia, Frank Picard, Swati Dumitras, Ralph Woessner

Anal Bioanal Chem· January 2013

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Systemic pharmacokinetics of indacaterol, an inhaled once-daily long-acting beta2-agonist, in different ethnic populations.
Soichiro Matsushima, Ivan Matthews, Ralph Woessner, Gregory Pinault, Hisanori Hara

Int J Clin Pharmacol Ther· August 2012

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Validation of an on-line solid-phase extraction method coupled to liquid chromatography-tandem mass spectrometry detection for the determination of Indacaterol in human serum.
Corinne Emotte, Olivier Heudi, Fanny Deglave, Adrien Bonvie, Laurence Masson, Ralph Woessner

J Chromatogr B Analyt Technol Biomed Life Sci· May 2012

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