Publications by authors named "Randy Bledsoe"

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Modular Protein Ligation: A New Paradigm as a Reagent Platform for Pre-Clinical Drug Discovery.
Rosalie Matico, Lawrence M Szewczuk, Beth Pietrak, Stephanie Chen, Ed Dul, Randy Bledsoe

Sci Rep· September 2019

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The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.
Edgar R Wood, Randy Bledsoe, Jing Chai, Philias Daka, Hongfeng Deng

J Biol Chem· August 2015

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Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor.
Keith Biggadike, Randy K Bledsoe, Diane M Coe, Tony W J Cooper, David House

Proc Natl Acad Sci U S A· October 2009

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The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist.
Kevin P Madauss, Randy K Bledsoe, Iain Mclay, Eugene L Stewart, Iain J Uings

Bioorg Med Chem Lett· December 2008

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Expression, purification, and characterization of multiple, multifunctional human glucocorticoid receptor proteins.
Catherine A Simmons, Randy K Bledsoe, Nicolas Guex, Kenneth H Pearce

Protein Expr Purif· November 2008

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X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocorticoid receptor-ligand binding domain.
Keith Biggadike, Randy K Bledsoe, Anne M Hassell, Barrie E Kirk, Iain M McLay

J Med Chem· June 2008

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Crystallization of protein-ligand complexes.
Anne M Hassell, Gang An, Randy K Bledsoe, Jane M Bynum, H Luke Carter

Acta Crystallogr D Biol Crystallogr· January 2007

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A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor.
Randy K Bledsoe, Kevin P Madauss, Jason A Holt, Christopher J Apolito, Millard H Lambert

J Biol Chem· September 2005

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Structure and function of the glucocorticoid receptor ligand binding domain.
Randy K Bledsoe, Eugene L Stewart, Kenneth H Pearce

Vitam Horm· August 2004

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Structure-based design of potent retinoid X receptor alpha agonists.
Curt D Haffner, James M Lenhard, Aaron B Miller, Darryl L McDougald, Kate Dwornik, Randy K Bledsoe

J Med Chem· April 2004

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X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch.
Shawn Williams, Randy K Bledsoe, Jon L Collins, Sharon Boggs, Millard H Lambert

J Biol Chem· July 2003

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Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition.
Randy K Bledsoe, Valerie G Montana, Thomas B Stanley, Chris J Delves, Christopher J Apolito

Cell· July 2002

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Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662.
Lisa M Leesnitzer, Derek J Parks, Randy K Bledsoe, Jeff E Cobb, Jon L Collins

Biochemistry· May 2002

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