Publications by authors named "Randy L Webb"

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The effect of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan, on central nervous system amyloid-β concentrations and clearance in the cynomolgus monkey.
Heidi A Schoenfeld, Tim West, Philip B Verghese, Mary Holubasch, Neeta Shenoy, Randy L Webb

Toxicol Appl Pharmacol· May 2017

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Characterization and Prediction of Cardiovascular Effects of Fingolimod and Siponimod Using a Systems Pharmacology Modeling Approach.
Nelleke Snelder, Bart A Ploeger, Olivier Luttringer, Dean F Rigel, Randy L Webb

J Pharmacol Exp Ther· February 2017

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trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linker.
Holger Sellner, Sylvain Cottens, Frédéric Cumin, Claus Ehrhardt, Takatoshi Kosaka, Randy L Webb

Bioorg Med Chem Lett· April 2015

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Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors.
Takeru Ehara, Osamu Irie, Takatoshi Kosaka, Takanori Kanazawa, Werner Breitenstein, Randy L Webb

ACS Med Chem Lett· July 2014

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A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.
Nils Ostermann, Simon Ruedisser, Claus Ehrhardt, Werner Breitenstein, Andreas Marzinzik, Randy L Webb

J Med Chem· March 2013

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The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches.
Edwige Lorthiois, Werner Breitenstein, Frederic Cumin, Claus Ehrhardt, Eric Francotte, Randy L Webb

J Med Chem· March 2013

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Direct renin inhibitors as a new therapy for hypertension.
Randy L Webb, Nikolaus Schiering, Richard Sedrani, Jürgen Maibaum

J Med Chem· November 2010

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Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone.
Paul Mulder, Virginie Mellin, Julie Favre, Magali Vercauteren, Isabelle Remy-Jouet, Randy L Webb

Eur Heart J· September 2008

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Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats.
David L Feldman, Liang Jin, Hong Xuan, Aurelie Contrepas, Yinong Zhou, Randy L Webb

Hypertension· July 2008

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Effects of combined AT1 receptor antagonist/NEP inhibitor on vascular remodeling and cardiac fibrosis in SHRSP.
Qian Pu, Pascal Brassard, Danesh M Javeshghani, Marc Iglarz, Randy L Webb

J Hypertens· February 2008

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Beneficial effects of combined benazepril-amlodipine on cardiac nitric oxide, cGMP, and TNF-alpha production after cardiac ischemia.
Helmy M Siragy, Chun Xue, Randy L Webb

J Cardiovasc Pharmacol· May 2006

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Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats.
Bernhard Pilz, Erdenechimeg Shagdarsuren, Maren Wellner, Anette Fiebeler, Ralf Dechend, Randy L Webb

Hypertension· September 2005

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Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage.
Anette Fiebeler, Jürg Nussberger, Erdenechimeg Shagdarsuren, Song Rong, Georg Hilfenhaus, Randy L Webb

Circulation· June 2005

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Increased renal production of angiotensin II and thromboxane B2 in conscious diabetic rats.
Alaa S Awad, Randy L Webb, Robert M Carey, Helmy M Siragy

Am J Hypertens· April 2005

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Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats.
Jeanette M Wood, Christian R Schnell, Frederic Cumin, Joël Menard, Randy L Webb

J Hypertens· February 2005

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Synergistic stimulation of aldosterone production in human adrenocortical carcinoma NCI-H295R cells by endothelin-1 and angiotensin II.
Chii-Whei Hu, Randy L Webb, Arco Y Jeng

J Cardiovasc Pharmacol· November 2004

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Renal nitric oxide production is decreased in diabetic rats and improved by AT1 receptor blockade.
Alaa S Awad, Randy L Webb, Robert M Carey, Helmy M Siragy

J Hypertens· August 2004

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Effects of valsartan and valeryl 4-hydroxy valsartan on human platelets: a possible additional mechanism for clinical benefits.
Victor L Serebruany, Alex I Malinin, David R Lowry, David C Sane, Randy L Webb

J Cardiovasc Pharmacol· May 2004

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Combination of low-dose valsartan and enalapril improves endothelial dysfunction and coronary reserve in Nomega-nitro-L-arginine methyl ester-treated spontaneously hypertensive rats.
Marc de Gasparo, Patrick Hess, Martine Clozel, Elke Persohn, Danielle Roman, Randy L Webb

J Cardiovasc Pharmacol· November 2002

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Differences in AT2 -receptor stimulation between AT1 -receptor blockers valsartan and losartan quantified by renal interstitial fluid cGMP.
Helmy M Siragy, Mohamed A El-Kersh, Marc De Gasparo, Randy L Webb, Robert M Carey

J Hypertens· June 2002

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Dipeptide sulfonamides as endothelin ETA/ETB receptor antagonists.
Gary M Ksander, Suraj S Shetty, Dominick DelGrande, Joseph L Balwierczak, Charles W Bruseo, Randy L Webb

Can J Physiol Pharmacol· May 2002

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