Publications by authors named "Raphael Scharfmann"

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Killing of Human β-Cells by CD8+ T Cells Triggers Inflammatory Paracrine Signaling and Neighboring β-Cell Dysfunction.
Masaya Oshima, Clémentine Halliez, Farah Kobaisi, Nina Modé, Alexis Fouque, Raphael Scharfmann

Diabetes· January 2026

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A new form of diabetes caused by INS mutations defined by zygosity, stem cell and population data.
Yue Tong, Marianne Becker, Ulrike Schierloh, Flávia Natividade da Silva, Leena Haataja, Raphaël Scharfmann

EMBO Mol Med· January 2026

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MNX1 prevents somatostatin expression in human beta cells by repressing PERCC1.
Farah Kobaisi, Alexis Fouque, Philippe Ravassard, Olivier Albagli-Curiel, Raphael Scharfmann

Diabetologia· December 2025

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Constructing chimeric mouse islets to study alpha- and delta-cell influence on beta-cell feature.
Alexis Fouque, Masaya Oshima, Nina Mode, Romain Ducellier, Delphine Thibaut, Raphaël Scharfmann

Mol Metab· November 2025

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Recessive TMEM167A variants cause neonatal diabetes, microcephaly, and epilepsy syndrome.
Enrico Virgilio, Sylvia Tielens, Georgia Bonfield, Fang-Shin Nian, Toshiaki Sawatani, Raphael Scharfmann

J Clin Invest· November 2025

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Decoding adult murine pancreatic islet cell diversity through cell type-resolved proteomics and phosphoproteomics.
Marvin Thielert, Adrian Villalba, Vincenth Brennsteiner, Maria Wahle, Constantin Ammar, Raphaël Scharfmann

Commun Biol· October 2025

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Imaging Human Pancreatic Endocrinogenesis During Early Prenatal Life.
Adrian Villalba, Yorick Gitton, Virginie Aiello, Maryne Toupin, Séverine Mazaud-Guittot, Raphaël Scharfmann

Diabetes· March 2025

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Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells.
Alexia Carré, Fatoumata Samassa, Zhicheng Zhou, Javier Perez-Hernandez, Christiana Lekka, Raphael Scharfmann

Nat Commun· January 2025

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Inceptor binds to and directs insulin towards lysosomal degradation in β cells.
Johanna Siehler, Sara Bilekova, Prisca Chapouton, Alessandro Dema, Pascal Albanese, Raphael Scharfmann

Nat Metab· December 2024

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Functional genetics reveals the contribution of delta opioid receptor to type 2 diabetes and beta-cell function.
Sarah Meulebrouck, Judith Merrheim, Gurvan Queniat, Cyril Bourouh, Mehdi Derhourhi, Raphaël Scharfmann

Nat Commun· August 2024

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A 3D atlas of the human developing pancreas to explore progenitor proliferation and differentiation.
Adrian Villalba, Yorick Gitton, Megumi Inoue, Virginie Aiello, Raphaël Blain, Raphaël Scharfmann

Diabetologia· June 2024

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Islet cell stress induced by insulin-degrading enzyme deficiency promotes regeneration and protection from autoimmune diabetes.
Shuaishuai Zhu, Emmanuelle Waeckel-Énée, Masaya Oshima, Anna Moser, Marie-Andrée Bessard, Raphael Scharfmann

iScience· June 2024

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LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells.
Federica Cuozzo, Katrina Viloria, Ali H Shilleh, Daniela Nasteska, Charlotte Frazer-Morris, Raphaël Scharfmann

Cell Rep· April 2024

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Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8 T cell responses.
Federica Vecchio, Alexia Carré, Daniil Korenkov, Zhicheng Zhou, Paola Apaolaza, Raphael Scharfmann

Sci Adv· March 2024

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EndoC-βH5 cells are storable and ready-to-use human pancreatic beta cells with physiological insulin secretion.
Bruno Blanchi, Marion Taurand, Claire Colace, Sofia Thomaidou, Charlotte Audeoud, Raphaël Scharfmann

Mol Metab· October 2023

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Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity.
Wenwen Gao, Lei Liu, Eunna Huh, Florence Gbahou, Erika Cecon, Raphael Scharfmann

Nat Metab· October 2023

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Tryptophan metabolism promotes immune evasion in human pancreatic β cells.
Latif Rachdi, Zhicheng Zhou, Claire Berthault, Chloe Lourenço, Alexis Fouque, Raphael Scharfmann

EBioMedicine· September 2023

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Interferon-α promotes neo-antigen formation and preferential HLA-B-restricted antigen presentation in pancreatic β-cells.
Alexia Carré, Zhicheng Zhou, Javier Perez-Hernandez, Fatoumata Samassa, Christiana Lekka, Raphael Scharfmann

bioRxiv· September 2023

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Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses.
Federica Vecchio, Alexia Carré, Daniil Korenkov, Zhicheng Zhou, Paola Apaolaza, Raphael Scharfmann

bioRxiv· August 2023

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Pancreatic Islet Cells Response to IFNγ Relies on Their Spatial Location within an Islet.
Marine De Burghgrave, Chloé Lourenço, Claire Berthault, Virginie Aiello, Adrian Villalba, Raphaël Scharfmann

Cells· December 2022

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Glucose controls co-translation of structurally related mRNAs the mTOR and eIF2 pathways in human pancreatic beta cells.
Manuel Bulfoni, Costas Bouyioukos, Albatoul Zakaria, Fabienne Nigon, Roberta Rapone, Raphaël Scharfmann

Front Endocrinol (Lausanne)· August 2022

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Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuits.
Kevin Saitoski, Maria Ryaboshapkina, Ghaith M Hamza, Andrew F Jarnuczak, Claire Berthault, Raphael Scharfmann

J Biol Chem· July 2022

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Mitchell-Riley Syndrome: Improving Clinical Outcomes and Searching for Functional Impact of RFX-6 Mutations.
Caroline de Gouveia Buff Passone, Gaëlle Vermillac, Willem Staels, Alix Besancon, Dulanjalee Kariyawasam, Raphaël Scharfmann

Front Endocrinol (Lausanne)· July 2022

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Characterization of the Secretome, Transcriptome, and Proteome of Human β Cell Line EndoC-βH1.
Maria Ryaboshapkina, Kevin Saitoski, Ghaith M Hamza, Andrew F Jarnuczak, Séverine Pechberty, Raphael Scharfmann

Mol Cell Proteomics· May 2022

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Loss of Human Beta Cell Identity in a Reconstructed Omental Stromal Cell Environment.
Blandine Secco, Kevin Saitoski, Karima Drareni, Antoine Soprani, Severine Pechberty, Raphaël Scharfmann

Cells· March 2022

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