Publications by authors named "Rasmus Clausen"

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Novel binding mode for negative allosteric NMDA receptor modulators.
James S Lotti, Jed T Syrenne, Avery J Benton, Ahmad Al-Mousawi, Lauren E Cornelison, Rasmus P Clausen

J Gen Physiol· January 2026

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UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors.
Avery J Benton, Mia R Johns, Emil Diamant, Nirvan Rouzbeh, Valdemar P Sørensen, Rasmus P Clausen

bioRxiv· November 2025

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Lower Blood Lactate Concentration and More Positive Affective Valence in Response to Reduced Exertion High Intensity Training (REHIT) on the Rowing Ergometer Compared to Cycle Ergometry.
Rasmus D Clausen, Todd A Astorino

Percept Mot Skills· June 2025

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Design of ()-3-(5-Thienyl)carboxamido-2-aminopropanoic Acid Derivatives as Novel NMDA Receptor Glycine Site Agonists: Variation in Molecular Geometry to Improve Potency and Augment GluN2 Subunit-Specific Activity.
Fabao Zhao, Unai Atxabal, Sofia Mariottini, Feng Yi, James S Lotti, Rasmus P Clausen

J Med Chem· February 2025

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Evaluation of allosteric N-methyl-d-aspartate receptor modulation by GluN2A-selective antagonists using pharmacological equilibrium modeling.
James S Lotti, Jaron Jones, Jill C Farnsworth, Feng Yi, Fabao Zhao, Rasmus P Clausen

Mol Pharmacol· January 2025

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Excess post-exercise oxygen consumption after reduced exertion high-intensity interval training on the cycle ergometer and rowing ergometer.
Rasmus Dahl Clausen, Todd A Astorino

Eur J Appl Physiol· March 2024

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ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs.
Elena Bechthold, Lucie Grey, Emil Diamant, Judith Schmidt, Ruben Steigerwald, Rasmus P Clausen

Biol Chem· March 2023

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Discovery of ()-2-amino-3-triazolpropanoic acid derivatives as NMDA receptor glycine site agonists with GluN2 subunit-specific activity.
Fabao Zhao, Georgios Mazis, Feng Yi, James S Lotti, Michael S Layeux, Rasmus P Clausen

Front Chem· November 2022

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Artificial Intelligence and Cheminformatics-Guided Modern Privileged Scaffold Research.
Han-Yue Qiu, Rasmus Praetorius Clausen, Yun He, Hai-Liang Zhu

Curr Top Med Chem· February 2022

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Derivatives of ()-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity.
Fabao Zhao, Unai Atxabal, Sofia Mariottini, Feng Yi, James S Lotti, Rasmus P Clausen

J Med Chem· January 2022

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GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain.
Ulrike Leurs, Anders B Klein, Ethan D McSpadden, Nane Griem-Krey, Sara M Ø Solbak, Rasmus P Clausen

Proc Natl Acad Sci U S A· August 2021

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Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery.
Sebastian Clementson, Sergio Armentia Matheu, Emil Märcher Rørsted, Henrik Pedersen, Anders A Jensen, Rasmus P Clausen

J Org Chem· June 2021

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Changes in VO2max and cardiac output in response to short-term high-intensity interval training in Caucasian and Hispanic young women: A pilot study.
Jamie L De Revere, Rasmus D Clausen, Todd A Astorino

PLoS One· May 2021

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Facilitation of GluN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model.
Jinxu Liu, Gajanan P Shelkar, Lopmudra P Sarode, Dinesh Y Gawande, Fabao Zhao, Rasmus Praetorius Clausen

Neurobiol Dis· March 2021

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Stereoselective synthesis of novel 2'-(S)-CCG-IV analogues as potent NMDA receptor agonists.
Alex Maolanon, Athanasios Papangelis, David Kawiecki, Tung-Chung Mou, Jed T Syrenne, Rasmus P Clausen

Eur J Med Chem· February 2021

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Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects.
Maria E K Lie, Stefanie Kickinger, Jonas Skovgaard-Petersen, Gerhard F Ecker, Rasmus P Clausen

Neurochem Res· July 2020

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Similar perceptual responses to reduced exertion high intensity interval training (REHIT) in adults differing in cardiorespiratory fitness.
Todd A Astorino, Rasmus Clausen, Joel Marroquin, Baliegh Arthur, Kevin Stiles

Physiol Behav· January 2020

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Modulation of burst firing of neurons in nucleus reticularis of the thalamus by GluN2C-containing NMDA receptors.
Jinxu Liu, Gajanan P Shelkar, Fabao Zhao, Rasmus Praetorius Clausen, Shashank Manohar Dravid

Mol Pharmacol· June 2019

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Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands.
Stefano Sainas, Piero Temperini, Jill C Farnsworth, Feng Yi, Stine Møllerud, Rasmus P Clausen

J Med Chem· May 2019

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Astrocytic GABA Transporters: Pharmacological Properties and Targets for Antiepileptic Drugs.
Arne Schousboe, Petrine Wellendorph, Bente Frølund, Rasmus P Clausen, Povl Krogsgaard-Larsen

Adv Neurobiol· September 2018

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Development of Non-GAT1-Selective Inhibitors: Challenges and Achievements.
Maria Damgaard, Anne Stæhr Haugaard, Stefanie Kickinger, Anas Al-Khawaja, Maria E K Lie, Rasmus Prætorius Clausen

Adv Neurobiol· September 2018

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Elucidation of fluorine's impact on p and Pgp-mediated efflux for a series of PDE9 inhibitors.
Kasper Fjelbye, Mauro Marigo, Rasmus P Clausen, Erling B Jørgensen, Claus T Christoffersen

Medchemcomm· May 2018

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Inhibition of GABA transporters fails to afford significant protection following focal cerebral ischemia.
Maria Ek Lie, Emma K Gowing, Rasmus P Clausen, Petrine Wellendorph, Andrew N Clarkson

J Cereb Blood Flow Metab· January 2018

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Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1).
Lars Jørgensen, Anas Al-Khawaja, Stefanie Kickinger, Stine B Vogensen, Jonas Skovgaard-Petersen, Rasmus P Clausen

J Med Chem· November 2017

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Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs.
Jacob Krall, Claus Hatt Jensen, Francesco Bavo, Christina Birkedahl Falk-Petersen, Anne Stæhr Haugaard, Rasmus Prætorius Clausen

J Med Chem· November 2017

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