Publications by authors named "Ravi Chari"

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A bispecific anti-MUC16/anti-death receptor 5 antibody achieves effective and tumor-selective death receptor 5-mediated tumor regression.
Victor S Goldmacher, Iosif Gershteyn, Ravi Chari, Yelena Kovtun

Sci Rep· March 2025

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Machine Learning Applied to Determine the Molecular Descriptors Responsible for the Viscosity Behavior of Concentrated Therapeutic Antibodies.
Pin-Kuang Lai, Amendra Fernando, Theresa K Cloutier, Yatin Gokarn, Jifeng Zhang, Ravi Chari

Mol Pharm· March 2021

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Antibody Co-Administration Can Improve Systemic and Local Distribution of Antibody-Drug Conjugates to Increase Efficacy.
Jose F Ponte, Leanne Lanieri, Eshita Khera, Rassol Laleau, Olga Ab, Ravi Chari

Mol Cancer Ther· January 2021

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Antibody-Drug Conjugates with Indolinobenzodiazepine Dimer Payloads: DNA-Binding Mechanism of Indolinobenzodiazepine Dimer Catabolites in Target Cancer Cells.
Rajeeva Singh, Emily E Reid, Luke Harris, Paulin L Salomon, Michael L Miller, Ravi V J Chari

Mol Pharm· January 2020

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Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody-Drug Conjugates with an Improved Therapeutic Index as Compared with Lysine Conjugation.
Chen Bai, Emily E Reid, Alan Wilhelm, Manami Shizuka, Erin K Maloney, Ravi Chari

Bioconjug Chem· January 2020

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Optimizing Lysosomal Activation of Antibody-Drug Conjugates (ADCs) by Incorporation of Novel Cleavable Dipeptide Linkers.
Paulin L Salomon, Emily E Reid, Katie E Archer, Luke Harris, Erin K Maloney, Ravi V J Chari

Mol Pharm· December 2019

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Synthesis and Evaluation of Camptothecin Antibody-Drug Conjugates.
Wei Li, Karen H Veale, Qifeng Qiu, Kerstin W Sinkevicius, Erin K Maloney, Ravi V J Chari

ACS Med Chem Lett· October 2019

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Peptide-Cleavable Self-immolative Maytansinoid Antibody-Drug Conjugates Designed To Provide Improved Bystander Killing.
Juliet A Costoplus, Karen H Veale, Qifeng Qiu, Jose F Ponte, Leanne Lanieri, Ravi V J Chari

ACS Med Chem Lett· October 2019

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Optimizing energy expenditure and oxygenation toward ventilator tolerance is associated with lower ventilator and intensive care unit days.
Darwin Ang, Ravi Chari, Alejandro Garcia, Jason Clark, Jason Farrah

J Trauma Acute Care Surg· September 2019

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Design, synthesis and evaluation of novel, potent DNA alkylating agents and their antibody-drug conjugates (ADCs).
Emily E Reid, Katie E Archer, Manami Shizuka, Molly A McShea, Erin K Maloney, Ravi V J Chari

Bioorg Med Chem Lett· September 2019

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Effect of Linker Stereochemistry on the Activity of Indolinobenzodiazepine Containing Antibody-Drug Conjugates (ADCs).
Emily E Reid, Katie E Archer, Manami Shizuka, Alan Wilhelm, Nicholas C Yoder, Ravi V J Chari

ACS Med Chem Lett· August 2019

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Synthesis of Highly Potent N-10 Amino-Linked DNA-Alkylating Indolinobenzodiazepine Antibody-Drug Conjugates (ADCs).
Katie E Archer, Emily E Reid, Manami Shizuka, James Woods, Luke Harris, Ravi V J Chari

ACS Med Chem Lett· August 2019

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A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells.
Yelena Kovtun, Gregory E Jones, Sharlene Adams, Lauren Harvey, Charlene A Audette, Ravi V J Chari

Blood Adv· April 2018

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A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs).
Michael L Miller, Manami Shizuka, Alan Wilhelm, Paulin Salomon, Emily E Reid, Ravi V J Chari

Mol Cancer Ther· March 2018

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Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates.
Xiuxia Sun, Jose F Ponte, Nicholas C Yoder, Rassol Laleau, Jennifer Coccia, Ravi Chari

Bioconjug Chem· May 2017

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Expanding the Reach of Antibody-Drug Conjugates.
Ravi V J Chari

ACS Med Chem Lett· November 2016

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A New Class of Antibody-Drug Conjugates with Potent DNA Alkylating Activity.
Michael L Miller, Nathan E Fishkin, Wei Li, Kathleen R Whiteman, Yelena Kovtun, Ravi V J Chari

Mol Cancer Ther· August 2016

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Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates.
Jose F Ponte, Xiuxia Sun, Nicholas C Yoder, Nathan Fishkin, Rassol Laleau, Ravi Chari

Bioconjug Chem· July 2016

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A New Triglycyl Peptide Linker for Antibody-Drug Conjugates (ADCs) with Improved Targeted Killing of Cancer Cells.
Rajeeva Singh, Yulius Y Setiady, Jose Ponte, Yelena V Kovtun, Katharine C Lai, Ravi V J Chari

Mol Cancer Ther· June 2016

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Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β.
Susan E Lacy, Chengbin Wu, Dominic J Ambrosi, Chung-Ming Hsieh, Sahana Bose, Ravi Chari

MAbs· March 2016

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Evaluation of Targets for Maytansinoid ADC Therapy Using a Novel Radiochemical Assay.
Katharine C Lai, Jutta Deckert, Yulius Y Setiady, Prerak Shah, Lintao Wang, Ravi Chari

Pharm Res· November 2015

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Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing.
Wayne C Widdison, Jose F Ponte, Jennifer A Coccia, Leanne Lanieri, Yulius Setiady, Ravi V J Chari

Bioconjug Chem· November 2015

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Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies.
Wayne Widdison, Sharon Wilhelm, Karen Veale, Juliet Costoplus, Gregory Jones, Ravi Chari

Mol Pharm· June 2015

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Ado-trastuzumab Emtansine (T-DM1): an antibody-drug conjugate (ADC) for HER2-positive breast cancer.
John M Lambert, Ravi V J Chari

J Med Chem· August 2014

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Antibody-drug conjugates: an emerging concept in cancer therapy.
Ravi V J Chari, Michael L Miller, Wayne C Widdison

Angew Chem Int Ed Engl· April 2014

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