Publications by authors named "Rayk Behrendt"

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AYLo study-elevated relapse risk and dysregulated proinflammatory signalling in giant cell arteritis patients with mosaic loss of the Y chromosome.
Simon M Petzinna, Sophie-Marie Kirch, Maike S Adamson, De Xi, Claus-Jürgen Bauer, Rayk Behrendt

Ann Rheum Dis· November 2025

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Local activation of mutant RIG-I by short noncoding Y-RNA in the kidney triggers lethal nephritis.
Saya Satoh, Yaw Bia Tan, Benjamin Heil, Shintaro Yamada, Verena Schütte, Rayk Behrendt

Sci Immunol· October 2025

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The E3 ubiquitin ligase MARCHF8 restricts HSV-1 infection by inhibiting replication of the viral genome.
Yongyan Xia, L Rayburn Nigos, Fernando Villalón-Letelier, Melkamu B Tessema, Andrew G Brooks, Rayk Behrendt

J Biol Chem· September 2025

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NIS-Seq enables cell-type-agnostic optical perturbation screening.
Caroline I Fandrey, Marius Jentzsch, Peter Konopka, Alexander Hoch, Katja Blumenstock, Rayk Behrendt

Nat Biotechnol· August 2025

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Systemic Inactivation of TREX1 Induces Selective Inflammation of the Tumor Microenvironment and Invigorated T-cell-Mediated Tumor Control.
Emilija Marinkovic, Minyi Chen, Nadja Schubert, Elif Dogan Dar, Tanja Poth, Rayk Behrendt

Cancer Res· August 2025

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Advanced imaging of relapse in giant cell arteritis: The role of vascular adhesion protein-1 and [Ga]Ga-DOTA-Siglec-9 positron emission tomography-computed tomography.
Simon M Petzinna, Jim Küppers, Benedikt Schemmer, Anna L Kernder, Claus-Jürgen Bauer, Rayk Behrendt

J Intern Med· June 2025

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The DNase TREX1 is a substrate of the intramembrane protease SPP with implications for disease pathogenesis.
Onur Kerem Tever, Torben Mentrup, Ivan Kingyue Chinn, Hitoshi Ishikuma, Regina Fluhrer, Rayk Behrendt

Cell Mol Life Sci· March 2025

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Cytosolic nucleic acid sensing as driver of critical illness: mechanisms and advances in therapy.
Zhaorong Chen, Rayk Behrendt, Lennart Wild, Martin Schlee, Christian Bode

Signal Transduct Target Ther· March 2025

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Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling.
Hella Luksch, Felix Schulze, David Geißler-Lösch, David Sprott, Lennart Höfs, Rayk Behrendt

Elife· March 2025

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Synthetic RIG-I agonist-mediated cancer immunotherapy synergizes with MAP kinase inhibition against BRAF-mutated melanoma.
Christian Grützner, Yu Pan Tan, Patrick Müller, Thais M Schlee-Guimaraes, Marius Jentzsch, Rayk Behrendt

Mol Ther Nucleic Acids· September 2024

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Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity.
Domnica Luca, Sumin Lee, Keiji Hirota, Yasutaka Okabe, Junji Uehori, Rayk Behrendt

Sci Adv· March 2024

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Removal of innate immune barriers allows efficient transduction of quiescent human hematopoietic stem cells.
Erika Valeri, Giulia Unali, Francesco Piras, Monah Abou-Alezz, Giulia Pais, Rayk Behrendt

Mol Ther· January 2024

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Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages.
Nilushi S De Silva, Johan Siewiera, Chantal Alkhoury, Guilherme P F Nader, Francesca Nadalin, Rayk Behrendt

Nat Aging· October 2023

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Activation of the cGAS/STING Axis in Genome-Damaged Hematopoietic Cells Does Not Impact Blood Cell Formation or Leukemogenesis.
Nicole Dressel, Loreen Natusch, Clara M Munz, Santiago Costas Ramon, Mina N F Morcos, Rayk Behrendt

Cancer Res· September 2023

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RIG-I immunotherapy overcomes radioresistance in p53-positive malignant melanoma.
Silke Lambing, Yu Pan Tan, Paraskevi Vasileiadou, Stefan Holdenrieder, Patrick Müller, Rayk Behrendt

J Mol Cell Biol· June 2023

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Development of an RNase H2 Activity Assay for Clinical Screening.
Marian Simon Schulz, Cay Bennet Sartorius von Bach, Emilija Marinkovic, Claudia Günther, Rayk Behrendt

J Clin Med· February 2023

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Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner.
Tina Schumann, Santiago Costas Ramon, Nadja Schubert, Mohamad Aref Mayo, Melanie Hega, Rayk Behrendt

J Exp Med· January 2023

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Correction: Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing.
Nina Kessler, Susanne F Viehmann, Calvin Krollmann, Karola Mai, Katharina M Kirschner, Rayk Behrendt

J Exp Med· December 2022

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Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing.
Nina Kessler, Susanne F Viehmann, Calvin Krollmann, Karola Mai, Katharina M Kirschner, Rayk Behrendt

J Exp Med· October 2022

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Efficient production of inhibitor-free foamy virus glycoprotein-containing retroviral vectors by proteoglycan-deficient packaging cells.
Clara Marie Munz, Henriette Kreher, Alexander Erdbeer, Stefanie Richter, Dana Westphal, Rayk Behrendt

Mol Ther Methods Clin Dev· September 2022

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Genome Replication Is Associated With Release of Immunogenic DNA Waste.
Nadja Schubert, Tina Schumann, Elena Daum, Karolin Flade, Yan Ge, Rayk Behrendt

Front Immunol· June 2022

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SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice Exposed to Lipopolysaccharide.
BradleyS Barrett, David H Nguyen, Joella Xu, Kejun Guo, Shravida Shetty, Rayk Behrendt

J Immunol· January 2022

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Animal models of SARS-CoV-2 and COVID-19 for the development of prophylactic and therapeutic interventions.
Marcel Renn, Eva Bartok, Thomas Zillinger, Gunther Hartmann, Rayk Behrendt

Pharmacol Ther· December 2021

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Low Threshold for Cutaneous Allergen Sensitization but No Spontaneous Dermatitis or Atopy in FLG-Deficient Mice.
Lina Muhandes, Maria Chapsa, Martin Pippel, Rayk Behrendt, Yan Ge

J Invest Dermatol· November 2021

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A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology.
Thaneas Prabakaran, Anne Troldborg, Sarinya Kumpunya, Isara Alee, Emilija Marinković, Rayk Behrendt

EBioMedicine· April 2021

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