Publications by authors named "Raymond Firestone"

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Experimental evidence of good efficacy and reduced toxicity with peptide-doxorubicin to treat gastric cancer.
Jue Zhang, Jing-Ping Yuan, Qun Wang, Li-Hua Shao, Shao-Ping Liu, Raymond A Firestone

Oncotarget· January 2018

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Synergistic Anticancer Action of Lysosomal Membrane Permeabilization and Glycolysis Inhibition.
Milica Kosic, Katarina Arsikin-Csordas, Verica Paunovic, Raymond A Firestone, Biljana Ristic

J Biol Chem· October 2016

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Anti-cancer effects of novel doxorubicin prodrug PDOX in MCF-7 breast cancer cells.
Jue Zhang, Liang He, Xia-Fei Geng, Raymond A Firestone, Ya-Ping Hong

J Huazhong Univ Sci Technolog Med Sci· August 2014

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Synthesis, identification and in vivo studies of tumor-targeting agent peptide doxorubicin (PDOX) to treat peritoneal carcinomatosis of gastric cancer with similar efficacy but reduced toxicity.
Li Tang, Rui Duan, Yan-jun Zhong, Raymond A Firestone, Ya-ping Hong

Mol Cancer· March 2014

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Anticancer effects of Ac‑Phe‑Lys‑PABC‑doxorubicin via mitochondria‑centered apoptosis involving reactive oxidative stress and the ERK1/2 signaling pathway in MGC‑803 cells.
Yan-Jun Zhong, Shao-Ping Liu, Raymond A Firestone, Ya-Ping Hong, Yan Li

Oncol Rep· October 2013

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Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical study.
Qun Wang, Yan-Jun Zhong, Jing-Ping Yuan, Li-Hua Shao, Jue Zhang, Raymond A Firestone

J Transl Med· August 2013

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Cathepsin B cleavable novel prodrug Ac-Phe-Lys-PABC-ADM enhances efficacy at reduced toxicity in treating gastric cancer peritoneal carcinomatosis: an experimental study.
Li-Hua Shao, Shao-Ping Liu, Jin-Xuan Hou, Yan-Hua Zhang, Chun-Wei Peng, Raymond A Firestone

Cancer· June 2012

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Lessons from 54 years of pharmaceutical research.
Raymond A Firestone

Nat Rev Drug Discov· October 2011

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Studies with vitamin E and beta-carotene as single agents do not prove lack of benefit.
Raymond A Firestone

Br J Nutr· November 2007

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Lipid-lowering agents may fight cancer by denying it LDL.
Raymond A Firestone

Int J Cancer· November 2006

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Drug giants hamstrung by timid middle management.
Raymond A Firestone

Nature· May 2006

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Monoclonal antibody mediated intracellular targeting of tallysomycin S(10b).
Michael A Walker, H Dalton King, Richard A Dalterio, Pamela Trail, Raymond Firestone

Bioorg Med Chem Lett· August 2004

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Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigen-specific in vitro anticancer activity.
Gene M Dubowchik, Raymond A Firestone, Linda Padilla, David Willner, Sandra J Hofstead

Bioconjug Chem· August 2003

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BR96 conjugates of highly potent anthracyclines.
H Dalton King, Andrew J Staab, Kahnie Pham-Kaplita, Derek Yurgaitis, Raymond A Firestone

Bioorg Med Chem Lett· July 2003

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The design of potent hydrazones and disulfides as cathepsin S inhibitors.
Charles L Cywin, Raymond A Firestone, Daniel W McNeil, Christine A Grygon, Kathryn M Crane

Bioorg Med Chem· March 2003

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Monoclonal antibody conjugates of doxorubicin prepared with branched peptide linkers: inhibition of aggregation by methoxytriethyleneglycol chains.
H Dalton King, Gene M Dubowchik, Harold Mastalerz, David Willner, Sandra J Hofstead, Raymond A Firestone

J Med Chem· September 2002

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Doxorubicin immunoconjugates containing bivalent, lysosomally-cleavable dipeptide linkages.
Gene M Dubowchik, Shilpa Radia, Harold Mastalerz, Michael A Walker, Raymond A Firestone

Bioorg Med Chem Lett· June 2002

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Synthesis of an immunoconjugate of camptothecin.
Michael A Walker, Gene M Dubowchik, Sandra J Hofstead, Pamela A Trail, Raymond A Firestone

Bioorg Med Chem Lett· January 2002

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Catalysis of Claisen Rearrangement by Low Molecular Weight Polyethylene(1).
Kevin A. Swiss, Raymond A. Firestone

J Org Chem· March 1999

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Amines That Transport Protons across Bilayer Membranes: Synthesis, Lysosomal Neutralization, and Two-Phase pK(a) Values by NMR.
Gene M. Dubowchik, Linda Padilla, Kurt Edinger, Raymond A. Firestone

J Org Chem· July 1996

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Mechanism-Based Enzyme Inactivation Using an Allyl Sulfoxide-Allyl Sulfenate Ester Rearrangement.
Michael Johnston, Ronald Raines, Christopher Walsh, Raymond A Firestone

J Am Chem Soc· June 1980

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