Publications by authors named "Raymond Winquist"

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Inhibiting Cytosine-Adenine-Guanine (CAG) repeat expansions as a therapeutic strategy for Huntington's disease.
Raymond J Winquist, Bruce Church

Biochem Pharmacol· December 2025

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The contribution of Na1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and Na1.6 gain-of-function (GOF) mouse seizure control.
James P Johnson, Thilo Focken, Parisa Karimi Tari, Celine Dube, Samuel J Goodchild, Raymond Winquist

Br J Pharmacol· October 2024

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Autologous human preclinical modeling of melanoma interpatient clinical responses to immunotherapeutics.
Yee Peng Phoon, Jared E Lopes, Lukas W Pfannenstiel, Claudia Marcela Diaz-Montero, Ye F Tian, Raymond Winquist

J Immunother Cancer· April 2024

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Potassium channelopathies associated with epilepsy-related syndromes and directions for therapeutic intervention.
Valentin K Gribkoff, Raymond J Winquist

Biochem Pharmacol· February 2023

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Nemvaleukin alfa, a novel engineered IL-2 fusion protein, drives antitumor immunity and inhibits tumor growth in small cell lung cancer.
Yuanwang Pan, Yuan Hao, Han Han, Ting Chen, Hailin Ding, Raymond J Winquist

J Immunother Cancer· September 2022

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Cardiovascular effects of GLP-1 receptor agonism.
Raymond J Winquist, Valentin K Gribkoff

Adv Pharmacol· June 2022

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NBI-921352, a first-in-class, Na1.6 selective, sodium channel inhibitor that prevents seizures in gain-of-function mice, and wild-type mice and rats.
J P Johnson, Thilo Focken, Kuldip Khakh, Parisa Karimi Tari, Celine Dube, Raymond Winquist

Elife· March 2022

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Targeting putative components of the mitochondrial permeability transition pore for novel therapeutics.
Raymond J Winquist, Valentin K Gribkoff

Biochem Pharmacol· July 2020

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Integration of biological/pathophysiological contexts to help clarify genotype-phenotype mismatches in monogenetic diseases. Childhood epilepsies associated with SCN2A as a case study.
Raymond J Winquist, Charles J Cohen

Biochem Pharmacol· May 2018

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Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases.
Luc J Farmer, Mark W Ledeboer, Thomas Hoock, Michael J Arnost, Randy S Bethiel, Raymond J Winquist

J Med Chem· September 2015

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Evaluating the immortal strand hypothesis in cancer stem cells: symmetric/self-renewal as the relevant surrogate marker of tumorigenicity.
Raymond J Winquist, Amy B Hall, Brenda K Eustace, Brinley F Furey

Biochem Pharmacol· September 2014

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The fall and rise of pharmacology--(re-)defining the discipline?
Raymond J Winquist, Kevin Mullane, Michael Williams

Biochem Pharmacol· January 2014

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Translational paradigms in pharmacology and drug discovery.
Kevin Mullane, Raymond J Winquist, Michael Williams

Biochem Pharmacol· January 2014

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Pharmacology in 21st century biomedical research. Preface.
Kevin Mullane, Michael Williams, Raymond Winquist

Biochem Pharmacol· January 2014

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Replicated, replicable and relevant-target engagement and pharmacological experimentation in the 21st century.
Terry Kenakin, David B Bylund, Myron L Toews, Kevin Mullane, Raymond J Winquist

Biochem Pharmacol· January 2014

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Island biogeography effects on microbial evolution may contribute to Crohn's disease.
Mac A Johnson, Raymond J Winquist

Biochem Pharmacol· December 2011

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Cancer stem cells as the relevant biomass for drug discovery.
Raymond J Winquist, Brinley F Furey, Diane M Boucher

Curr Opin Pharmacol· August 2010

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Factors influencing development of new therapeutics for oncology.
Raymond J Winquist, Diane M Boucher

Curr Opin Pharmacol· August 2010

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Targeting cancer stem cells for more effective therapies: Taking out cancer's locomotive engine.
Raymond J Winquist, Diane M Boucher, Mark Wood, Brinley F Furey

Biochem Pharmacol· August 2009

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The complex etiology of multiple sclerosis.
Raymond J Winquist, Ann Kwong, Ravi Ramachandran, Jugnu Jain

Biochem Pharmacol· November 2007

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Use-dependent blockade of Cav2.2 voltage-gated calcium channels for neuropathic pain.
Raymond J Winquist, Jennifer Qian Pan, Valentin K Gribkoff

Biochem Pharmacol· August 2005

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Voltage-gated cation channel modulators for the treatment of stroke.
Valentin K Gribkoff, Raymond J Winquist

Expert Opin Investig Drugs· May 2005

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