Publications by authors named "Rebecca A Clewell"

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Evaluation of a high-throughput in-vitro-to-in-vivo extrapolation (IVIVE) workflow for the prioritization of potential developmental toxicity of chemicals.
Matthew W Linakis, Rebecca A Clewell, Jerry Campbell, P Robinan Gentry, Harvey J Clewell

ALTEX· October 2025

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Development of Preliminary Candidate Surface Guidelines for Air Force-Relevant Dermal Sensitizers Using New Approach Methodologies.
Andrew J Keebaugh, Megan L Steele, Argel Islas-Robles, Jakeb Phillips, Allison Hilberer, Rebecca A Clewell

Toxics· August 2025

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Prediction of Respiratory Irritation and Respiratory Sensitization of Chemicals Using Structural Alerts and Machine Learning Modeling.
Yaroslav Chushak, Andrew Keebaugh, Rebecca A Clewell

Toxics· March 2025

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Evaluating applicability domain of acute toxicity QSAR models for military and industrial chemical risk assessment.
Jennifer L Fisher, Kris Yamada, Andrew J Keebaugh, Kelly T Williams, Carrie L German, Rebecca A Clewell

Toxicol Lett· January 2025

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Comparison of Rat Hepatocyte 2D-Monocultures and Hepatocytes Non-Parenchymal Cell Co-Cultures for Assessing Chemical Toxicity.
Amy J Stefanowicz, Leslie Recio, Michael B Black, Tyler Beames, Melvin E Andersen, Rebecca A Clewell

Int J Toxicol· January 2023

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Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods.
Chantel I Nicolas, Matthew W Linakis, Melyssa S Minto, Kamel Mansouri, Rebecca A Clewell, Harvey J Clewell Iii

Front Pharmacol· October 2022

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An in vitro approach to determine the human relevance of anti-spermatogenic effects of 4-methylmorpholine 4-oxide, monohydrate (NMMO) in rat reproductive toxicity studies.
Rebecca A Clewell, Harvey J Clewell, Matthew W Linakis, Charles A Easley, Jacqueline N Langmo

Toxicol In Vitro· August 2022

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Considerations for Improving Metabolism Predictions for to Extrapolation.
Marjory Moreau, Pankajini Mallick, Marci Smeltz, Saad Haider, Chantel I Nicolas, Rebecca A Clewell, Harvey J Clewell

Front Toxicol· April 2022

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Time-dependent genomic response in primary human uroepithelial cells exposed to arsenite for up to 60 days.
Alina Efremenko, Pergentino Balbuena, Rebecca A Clewell, Michael Black, Linda Pluta, Harvey J Clewell

Toxicology· September 2021

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Development of a physiologically based pharmacokinetic model of diisononyl phthalate (DiNP) in pregnant rat and human.
Jerry L Campbell, Rainer Otter, Warwick A Anderson, Matthew P Longnecker, Rebecca A Clewell, Harvey J Clewell

J Toxicol Environ Health A· October 2020

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Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates.
Rebecca A Clewell, Jeremy A Leonard, Chantel I Nicolas, Jerry L Campbell, Miyoung Yoon, Harvey J Clewell

Toxicol In Vitro· August 2020

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Developing context appropriate toxicity testing approaches using new alternative methods (NAMs).
Melvin E Andersen, Patrick D McMullen, Martin B Phillips, Miyoung Yoon, Salil N Pendse, Harvey J Clewell, Rebecca A Clewell

ALTEX· May 2020

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Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods.
Patrick D McMullen, Sudin Bhattacharya, Courtney G Woods, Salil N Pendse, Mary T McBride, Rebecca A Clewell

Toxicol In Vitro· April 2020

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The role of fit-for-purpose assays within tiered testing approaches: A case study evaluating prioritized estrogen-active compounds in an in vitro human uterotrophic assay.
Tyler Beames, Marjory Moreau, L Avery Roberts, Kamel Mansouri, Saad Haider, Rebecca A Clewell

Toxicol Appl Pharmacol· January 2020

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Addressing systematic inconsistencies between in vitro and in vivo transcriptomic mode of action signatures.
Patrick D McMullen, Salil N Pendse, Michael B Black, Kamel Mansouri, Saad Haider, Rebecca A Clewell

Toxicol In Vitro· August 2019

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An evaluation of the USEPA Proposed Approaches for applying a biologically based dose-response model in a risk assessment for perchlorate in drinking water.
Harvey J Clewell, P Robinan Gentry, C Eric Hack, Tracy Greene, Rebecca A Clewell

Regul Toxicol Pharmacol· April 2019

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Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment.
Rebecca A Clewell, Chad M Thompson, Harvey J Clewell

Chem Biol Interact· March 2019

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Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system.
Barbara A Wetmore, Rebecca A Clewell, Brian Cholewa, Bethany Parks, Salil N Pendse, Harvey J Clewell

Toxicol In Vitro· February 2019

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A Qualitative Modeling Approach for Whole Genome Prediction Using High-Throughput Toxicogenomics Data and Pathway-Based Validation.
Saad Haider, Michael B Black, Bethany B Parks, Briana Foley, Barbara A Wetmore, Rebecca A Clewell

Front Pharmacol· October 2018

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An in vitro approach for prioritization and evaluation of chemical effects on glucocorticoid receptor mediated adipogenesis.
Jessica K Hartman, Tyler Beames, Bethany Parks, Daniel Doheny, Gina Song, Rebecca A Clewell

Toxicol Appl Pharmacol· September 2018

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Evaluating opportunities for advancing the use of alternative methods in risk assessment through the development of fit-for-purpose in vitro assays.
Patrick D McMullen, Melvin E Andersen, Brian Cholewa, Harvey J Clewell, Katherine M Dunnick, Rebecca A Clewell

Toxicol In Vitro· April 2018

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Multiple receptors shape the estrogen response pathway and are critical considerations for the future of in vitro-based risk assessment efforts.
Michelle M Miller, Patrick D McMullen, Melvin E Andersen, Rebecca A Clewell

Crit Rev Toxicol· August 2017

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Pathway Based Toxicology and Fit-for-Purpose Assays.
Rebecca A Clewell, Patrick D McMullen, Yeyejide Adeleye, Paul L Carmichael, Melvin E Andersen

Adv Exp Med Biol· June 2017

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Contribution of ATM and ATR kinase pathways to p53-mediated response in etoposide and methyl methanesulfonate induced DNA damage.
Bin Sun, Susan M Ross, Sean Rowley, Yeyejide Adeleye, Rebecca A Clewell

Environ Mol Mutagen· March 2017

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Editor's Highlight: Development of an In vitro Assay Measuring Uterine-Specific Estrogenic Responses for Use in Chemical Safety Assessment.
Michelle M Miller, Rebecca A Alyea, Caroline LeSommer, Daniel L Doheny, Sean M Rowley, Rebecca A Clewell

Toxicol Sci· November 2016

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