Publications by authors named "Reisa A Sperling"

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Living Alone, Early Tau Pathology, and Loneliness in Cognitively Unimpaired Older Adults During the COVID-19 Pandemic.
Benjamin S Zide, Geoffroy Gagliardi, Heidi I L Jacobs, Jennifer R Gatchel, Yakeel T Quiroz, Reisa A Sperling

Am J Geriatr Psychiatry· January 2026

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Physical activity as a modifiable risk factor in preclinical Alzheimer's disease.
Wai-Ying Wendy Yau, Dylan R Kirn, Jennifer S Rabin, Michael J Properzi, Aaron P Schultz, Reisa A Sperling

Nat Med· December 2025

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Associations of lifestyle factors with amyloid pathology in persons without dementia.
Julie E Oomens, Stephanie Jb Vos, Nancy N Maserejian, Mercè Boada, Mira Didic, Reisa A Sperling

J Alzheimers Dis· December 2025

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Blood gene expression network expression strongly relates to brain amyloid burden.
Vaibhav A Janve, Mabel Seto, Reisa A Sperling, Paul S Aisen, Robert A Rissman

Alzheimers Dement· December 2025

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Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test.
Jessie Fanglu Fu, Talia Robinson, Marina Rodriguez Alonso, Adela Francis Malave, Roos J Jutten, Reisa A Sperling

Ann Clin Transl Neurol· November 2025

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Prognostic value of plasma glial fibrillary acidic protein in cognitively unimpaired older adults: Results from the A4 study.
Elham Ghanbarian, Tianchen Qian, Babak Khorsand, Lukai Zheng, S Ahmad Sajjadi, Reisa A Sperling

Alzheimers Dement· November 2025

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Prognostic performance across Alzheimer's biomarkers, multi-modal physiological measures, and clinical history in asymptomatic individuals.
Randall J Ellis, Audrey Airaud, Varuna H Jasodanand, Sahana S Kowshik, Matteo Bellitti, Reisa A Sperling

medRxiv· November 2025

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Blood-based Transcriptomics Reveal Sex- and Amyloid-Modulated Biology of Plasma pTau217 in Preclinical Alzheimer's Disease.
Mabel Seto, Hannah M Klinger, Michelle Clifton, Vaibhav A Janve, Jane A Brown, Reisa A Sperling

bioRxiv· November 2025

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Concurrent Changes in Plasma Phosphorylated Tau 217, Tau PET, and Cognition in Preclinical Alzheimer Disease.
Philip S Insel, Niklas Mattsson-Carlgren, Oliver Langford, Vincent M Caruso, Antoine Leuzy, Reisa A Sperling

JAMA Neurol· October 2025

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Independent effects of white matter lesion volume and APOE ɛ4 on ARIA-H in A4 Study.
Zahra Shirzadi, Aaron P Schultz, Nazila Loghmani, Hyun-Sik Yang, Jeremy Ford, Reisa A Sperling

Alzheimers Dement· October 2025

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Recruitment and retention in a preclinical AD trial: comparisons between academic and non-academic sites.
Marina Ritchie, Kedir Hussen, Oliver Langford, Christian Navarro, Zara Kotadiya, Reisa A Sperling

Alzheimers Res Ther· October 2025

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Tau biology, biomarkers, and therapeutics.
Bess Frost, Hartmuth Kolb, Alicia Algeciras-Schimnich, Tobey J Betthauser, Sarah DeVos, Reisa A Sperling

Alzheimers Dement (N Y)· October 2025

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Using memory recall response time on digital cognitive testing to detect subtle cognitive changes among cognitively unimpaired older adults.
Hairin Kim, Roos J Jutten, Daniel Soberanes, Mark A Dubbelman, Lia D'Aquila, Reisa A Sperling

Alzheimers Dement· October 2025

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Racial and ethnic differences in plasma p-tau217 ratio biomarker eligibility rates in a preclinical AD trial with lecanemab.
Doris P Molina-Henry, Rema Raman, Andy Liu, Oliver Langford, Joel B Braunstein, Reisa A Sperling

Alzheimers Dement (Amst)· September 2025

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Estimating the preclinical Alzheimer's disease course with multimodal data.
Diana L Townsend, Michael J Properzi, Tobey J Betthauser, Hannah M Klinger, Rory Boyle, Reisa A Sperling

Alzheimers Dement· September 2025

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Multimodal prognostic modeling of individual cognitive trajectories to enhance trial efficiency in preclinical Alzheimer's disease.
Viswanath Devanarayan, Michael C Donohue, Reisa A Sperling, Keith A Johnson, Yuanqing Ye

Alzheimers Dement· September 2025

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Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex.
Rik Ossenkoppele, Emma M Coomans, Liana G Apostolova, Suzanne L Baker, Henryk Barthel, Reisa A Sperling

Nat Neurosci· August 2025

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Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia-specific perspectives.
Takeshi Iwatsubo, Reisa A Sperling, Alicia Algeciras-Schimnich, Hidenori Arai, Anna M Barron

Alzheimers Dement· August 2025

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The Mobile Toolbox for remote, self-administered cognitive assessment in older adults: associations with in-clinic cognitive testing and Alzheimer's disease biomarkers.
Roos J Jutten, Jessa E Burling, Elliott Slade, Jackson C Thompson, Jessie Fanglu Fu, Reisa A Sperling

Alzheimers Dement (Amst)· August 2025

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Assessing Stages of Objective Memory Impairment and neuroimaging as risk factors of incident cognitive impairment.
Kellen K Petersen, Ali Ezzati, Bhargav T Nallapu, Richard B Lipton, Reisa A Sperling

J Int Neuropsychol Soc· August 2025

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Prognostic Value of Plasma Glial Fibrillary Acidic Protein in Cognitively Unimpaired Older Adults: Results from the A4 Study.
Elham Ghanbarian, Tianchen Qian, Babak Khorsand, Lukai Zheng, S Ahmad Sajjadi, Reisa A Sperling

medRxiv· August 2025

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Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity.
Alexis Moscoso, Fiona Heeman, Sheelakumari Raghavan, Alejandro Costoya-Sánchez, Martijn van Essen, Reisa A Sperling

JAMA· July 2025

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BrainAge moderates associations between Alzheimer's disease biomarkers and cognitive decline: a meta-analysis across A4/LEARN, HABS and ADNI cohorts.
Jorge Garcia Condado, Hannah M Klinger, Colin Birkenbihl, Madison Cuppels, Annie Liu, Reisa A Sperling

medRxiv· July 2025

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Relationship between BrainAge Polygenetic Risk Score and plasma biomarkers in the A4/LEARN studies.
Jorge Garcia Condado, Mabel Seto, Madison Cuppels, Colin Birkenbihl, Hannah M Klinger, Reisa A Sperling

medRxiv· July 2025

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Cognitive decline across five cognitive batteries: Sample size implications for clinical trials.
Andrea R Zammit, Ana W Capuano, Lisa L Barnes, Julie A Schneider, Reisa A Sperling

Alzheimers Dement (N Y)· July 2025

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