Publications by authors named "Remi Legay"

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Stereoselective Ring-Opening Reaction of α-Fluorinated Oxetanes: A Practical and Theoretical Investigation.
David Leparfait, Thibault Thierry, Nicola L da Rocha, Rémi Legay, Emmanuel Pfund

J Org Chem· December 2024

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Expanding the Repertoire of Low-Molecular-Weight Pentafluorosulfanyl-Substituted Scaffolds.
Arathy Jose, Daniel Guest, Remi LeGay, Graham J Tizzard, Simon J Coles

ChemMedChem· April 2022

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Convergent access to mono-fluoroalkene-based peptidomimetics.
Florent Larnaud, Charlène Calata, Anaïs Prunier, Clothilde Le Guen, Rémi Legay

Org Biomol Chem· February 2022

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Media-Driven Pd-Catalyzed Reaction Cascades with 1,3-Diynamides Leading Selectively to Either Indoles or Quinolines.
Illia Lenko, Alexander Mamontov, Carole Alayrac, Rémi Legay, Bernhard Witulski

Angew Chem Int Ed Engl· October 2021

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Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer's Disease Treatment through Rigidification Strategy.
Cédric Lecoutey, Rémi Legay, Audrey Davis, Jana Sopková-de Oliveira Santos, Patrick Dallemagne

Molecules· April 2021

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First Synthesis of Racemic Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer's Disease.
Benjamin Guieu, Cedric Lecoutey, Rémi Legay, Audrey Davis, Jana Sopkova de Oliveira Santos

Molecules· December 2020

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Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT receptors activities for the treatment of Alzheimer's disease.
Julien Lalut, Hugo Payan, Audrey Davis, Cédric Lecoutey, Rémi Legay

Sci Rep· February 2020

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Difluorophosphonylated Allylic Ether Moiety as a 2'-Modification of RNA-Type Molecules: Synthesis, Thermal, and Metabolic Studies.
Emmanuel Pfund, Christelle Dupouy, Sonia Rouanet, Rémi Legay, Cyril Lebargy

Org Lett· June 2019

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Microplate assay for lipophilicity determination using intrinsic fluorescence of drugs: Application to a promising anticancer lead, pyridoclax.
Willy Smeralda, Marc Since, Sophie Corvaisier, Rémi Legay, Anne-Sophie Voisin-Chiret

Eur J Pharm Sci· April 2019

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Structure-guided design of pyridoclax derivatives based on Noxa / Mcl-1 interaction mode.
Siham Hedir, Marcella De Giorgi, Jade Fogha, Martina De Pascale, Louis-Bastien Weiswald, Rémi Legay

Eur J Med Chem· November 2018

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Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment.
Jean-Pierre Jourdan, Marc Since, Laïla El Kihel, Cédric Lecoutey, Sophie Corvaisier, Rémi Legay

ChemMedChem· June 2017

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Borinic Acid Catalysed Reduction of Tertiary Amides with Hydrosilanes: A Mild and Chemoselective Synthesis of Amines.
Aurélien Chardon, Tharwat Mohy El Dine, Rémi Legay, Michaël De Paolis, Jacques Rouden

Chemistry· February 2017

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Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment.
Jean-Pierre Jourdan, Marc Since, Laïla El Kihel, Cédric Lecoutey, Sophie Corvaisier, Rémi Legay

Eur J Med Chem· May 2016

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Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.
Christophe Rochais, Cédric Lecoutey, Florence Gaven, Patrizia Giannoni, Katia Hamidouche, Remi Legay

J Med Chem· April 2015

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Hydrolytic pathway of 5-fluorouracil in aqueous solutions for clinical use.
Rémi Legay, Stéphane Massou, Joëlle Azéma, Robert Martino, Myriam Malet-Martino

J Pharm Biomed Anal· September 2014

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Zinc and cobalt complexes based on tripodal ligands: synthesis, structure and reactivity toward lactide.
Mathieu J-L Tschan, Jia Guo, Sumesh K Raman, Emilie Brulé, Thierry Roisnel, Rémi Legay

Dalton Trans· March 2014

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N-substituted piperazinopyridylsteroid derivatives as abiraterone analogues inhibit growth and induce pro-apoptosis in human hormone-independent prostate cancer cell lines.
Dominique Brossard, Ying Zhang, Shozeb M Haider, Miriam Sgobba, Mohamed Khalid, Rémi Legay

Chem Biol Drug Des· November 2013

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Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect.
Elizabeth Chosson, Francesca Santoro, Christophe Rochais, Jana Sopkova-de Oliveira Santos, Rémi Legay

Bioorg Med Chem· April 2012

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Structural characterizations of oligopyridyl foldamers, α-helix mimetics.
Jana Sopkova-de Oliveira Santos, Anne Sophie Voisin-Chiret, Gregory Burzicki, Laure Sebaoun, Muriel Sebban, Rémi Legay

J Chem Inf Model· February 2012

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Synthesis of 3-amino-thiochromanes from 4-benzyl 2-thiazolines, via an unprecedented intramolecular electrophilic aromatic substitution.
Guillaume Mercey, Remi Legay, Jean-François Lohier, Jana Sopkova-de Oliveira Santos, Jocelyne Levillain

Org Biomol Chem· June 2010

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Hydrogenative desulphurization of thienopyrrolizinones: an easy and selective access to (Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity.
Vittoria Perri, Christophe Rochais, Jana Sopkova-de Oliveira Santos, Rémi Legay, Thierry Cresteil

Eur J Med Chem· March 2010

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Synthesis of 2,3-trans disubstituted tetrahydrofurans through sequential xanthate radical addition-substitution reactions.
Laëtitia Jean-Baptiste, Sergiy Yemets, Rémi Legay, Thierry Lequeux

J Org Chem· March 2006

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Cardiotoxicity and neurotoxicity of high-dose continuous fluorouracil as a result of degradation compounds in the drug vials.
Johannes Lukaschek, Martin Nufer, Dominik Maurer, Maximilian Asanger, Hanspeter Honegger, Rémi Legay

J Clin Oncol· December 2004

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