Publications by authors named "Renae Ryan"

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Structural basis of sodium ion-dependent carnitine transport by OCTN2.
James S Davies, Yi C Zeng, Chelsea Briot, Simon H J Brown, Renae M Ryan

Nat Commun· November 2025

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Is ASCT2 a Suitable Vector for the Selective Delivery of Anticancer Drugs? Modification of Glutamine at Either the Carboxylate or the Side Chain Hinders Binding and Transport.
Vinitha M, Adnan Ibrahim Mohammed, Chelsea Briot, Renae M Ryan, Trevor W Hambley

ChemMedChem· March 2025

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An elastic siderophore synthetase and rubbery substrates assemble multimeric linear and macrocyclic hydroxamic acid metal chelators.
Kate P Nolan, Callum A Rosser, James L Wood, Josep Font, Athavan Sresutharsan, Renae M Ryan

Chem Sci· January 2025

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Structure, function, surf, repeat: A week at Lorne Proteins 2024.
Rosemary J Cater, Renae M Ryan, Jonathan S Oakhill, Peter Czabotar, James M Murphy

Structure· November 2024

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Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Yi C Zeng, Meghna Sobti, Ada Quinn, Nicola J Smith, Simon H J Brown, Renae M Ryan

Nat Commun· October 2023

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The twisting elevator mechanism of glutamate transporters reveals the structural basis for the dual transport-channel functions.
Ichia Chen, Qianyi Wu, Josep Font, Renae M Ryan

Curr Opin Struct Biol· August 2022

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Characterizing unexpected interactions of a glutamine transporter inhibitor with members of the SLC1A transporter family.
Natasha J Freidman, Chelsea Briot, Renae M Ryan

J Biol Chem· August 2022

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Ataxia-linked SLC1A3 mutations alter EAAT1 chloride channel activity and glial regulation of CNS function.
Qianyi Wu, Azman Akhter, Shashank Pant, Eunjoo Cho, Jin Xin Zhu, Renae M Ryan

J Clin Invest· April 2022

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Microscopic Characterization of the Chloride Permeation Pathway in the Human Excitatory Amino Acid Transporter 1 (EAAT1).
Shashank Pant, Qianyi Wu, Renae Ryan, Emad Tajkhorshid

ACS Chem Neurosci· March 2022

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Acetyl-CoA-Mediated Post-Biosynthetic Modification of Desferrioxamine B Generates - and N--Acetylated Isomers Controlled by a pH Switch.
Kate P Nolan, Josep Font, Athavan Sresutharsan, Michael P Gotsbacher, Christopher J M Brown, Renae M Ryan

ACS Chem Biol· February 2022

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Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia.
Jenny I Aguilar, Mary Hongying Cheng, Josep Font, Alexandra C Schwartz, Kaitlyn Ledwitch, Renae Monique Ryan

Elife· May 2021

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Regulation of Glutamate, GABA and Dopamine Transporter Uptake, Surface Mobility and Expression.
Renae M Ryan, Susan L Ingram, Annalisa Scimemi

Front Cell Neurosci· April 2021

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Glutamate transporters have a chloride channel with two hydrophobic gates.
Ichia Chen, Shashank Pant, Qianyi Wu, Rosemary J Cater, Meghna Sobti, Renae M Ryan

Nature· March 2021

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Amino Acid Transporters and Exchangers from the SLC1A Family: Structure, Mechanism and Roles in Physiology and Cancer.
Natasha Freidman, Ichia Chen, Qianyi Wu, Chelsea Briot, Jeff Holst, Renae Ryan

Neurochem Res· June 2020

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Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics.
Shannon N Mostyn, Katie A Wilson, Alexandra Schumann-Gillett, Zachary J Frangos, Susan Shimmon, Renae M Ryan

Elife· October 2019

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Development of an N-Acyl Amino Acid That Selectively Inhibits the Glycine Transporter 2 To Produce Analgesia in a Rat Model of Chronic Pain.
Shannon N Mostyn, Tristan Rawling, Sarasa Mohammadi, Susan Shimmon, Zachary J Frangos, Renae M Ryan

J Med Chem· March 2019

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Synthesis and in vitro evaluation of diverse heterocyclic diphenolic compounds as inhibitors of DYRK1A.
Qingqing Zhou, Tristan A Reekie, Ramzi H Abbassi, Dinesh Indurthi Venkata, Josep S Font, Renae M Ryan

Bioorg Med Chem· December 2018

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Regulation of SLC1A4 and SLC1A5 in Prostate Cancer-Letter.
Renae M Ryan, Jeff Holst

Mol Cancer Res· November 2018

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Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways.
Michelle van Geldermalsen, Lake-Ee Quek, Nigel Turner, Natasha Freidman, Angel Pang, Renae Ryan

BMC Cancer· June 2018

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Molecular Determinants for Substrate Interactions with the Glycine Transporter GlyT2.
Jane E Carland, Michael Thomas, Shannon N Mostyn, Nandhitha Subramanian, Megan L O'Mara, Renae M Ryan

ACS Chem Neurosci· March 2018

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Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5.
Amanda J Scopelliti, Josep Font, Robert J Vandenberg, Olga Boudker, Renae M Ryan

Nat Commun· January 2018

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Synthesis and Characterization of Novel Acyl-Glycine Inhibitors of GlyT2.
Shannon N Mostyn, Jane E Carland, Susan Shimmon, Renae M Ryan, Tristan Rawling

ACS Chem Neurosci· September 2017

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Structural Optimization and Pharmacological Evaluation of Inhibitors Targeting Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases (DYRK) and CDC-like kinases (CLK) in Glioblastoma.
Qingqing Zhou, Athena F Phoa, Ramzi H Abbassi, Monira Hoque, Tristan A Reekie, Renae M Ryan, Bryan W Day

J Med Chem· March 2017

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The amino acid transporter, SLC1A3, is plasma membrane-localised in adipocytes and its activity is insensitive to insulin.
James R Krycer, Daniel J Fazakerley, Rosemary J Cater, Kristen C Thomas, Sheyda Naghiloo, Renae M Ryan

FEBS Lett· January 2017

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Characterization of the Inward- and Outward-Facing Substrate Binding Sites of the Prokaryotic Aspartate Transporter, Glt.
Benjamin C McIlwain, Robert J Vandenberg, Renae M Ryan

Biochemistry· December 2016

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