Publications by authors named "Richard Graeff"

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Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-1-inosine 5'-monophosphate, Analogues and Early Structure-Activity Relationship.
Joanna M Watt, Richard Graeff, Barry V L Potter

Molecules· November 2021

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Novel Pathway of Adenosine Generation in the Lungs from NAD: Relevance to Allergic Airway Disease.
Richard Graeff, Alonso Guedes, Ruth Quintana, Erin Wendt-Hornickle, Caroline Baldo

Molecules· October 2020

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CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms.
Deepak A Deshpande, Alonso G P Guedes, Richard Graeff, Soner Dogan, Subbaya Subramanian

Mediators Inflamm· September 2018

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Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid "L-cyclic inosine 5'-diphosphate ribose".
Joanna M Watt, Richard Graeff, Mark P Thomas, Barry V L Potter

Sci Rep· November 2017

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CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template.
Christelle Moreau, Qun Liu, Richard Graeff, Gerd K Wagner, Mark P Thomas

PLoS One· October 2017

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Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH.
Ying-Ying Lu, Bai-Xia Hao, Richard Graeff, Connie W M Wong, Wu-Tian Wu

J Biol Chem· July 2017

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A novel modified vaccination technique produces IgG antibodies that cause complement-mediated lysis of multiple myeloma cells carrying CD38 antigen.
Arpad Z Barabas, Chad D Cole, Richard M Graeff, Tulin Morcol, Rene Lafreniere

Hum Antibodies· March 2017

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Suppression of tumor growth by a heterologous antibody directed against multiple myeloma dominant CD38 antigen in SCID mice injected with multiple myeloma cells.
Arpad Z Barabas, Chad D Cole, Richard M Graeff, Zoltan B Kovacs, Rene Lafreniere

Hum Antibodies· March 2017

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Tolerance, loss of tolerance and regaining tolerance to self by immune-mediated events.
Arpad Zsigmond Barabas, Chad Douglas Cole, Richard Milton Graeff, Rene Lafreniere, Donald Mackay Weir

Immunol Res· February 2017

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Porcine CD38 exhibits prominent secondary NAD(+) cyclase activity.
Kai Yiu Ting, Christina F P Leung, Richard M Graeff, Hon Cheung Lee, Quan Hao

Protein Sci· March 2016

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Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore.
Sean M Davidson, Kirsty Foote, Suma Kunuthur, Raj Gosain, Noah Tan, Richard Graeff

Cardiovasc Res· December 2015

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Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38.
Joanna M Swarbrick, Richard Graeff, Hongmin Zhang, Mark P Thomas, Quan Hao

J Med Chem· October 2014

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'Click cyclic ADP-ribose': a neutral second messenger mimic.
Joanna M Swarbrick, Richard Graeff, Clive Garnham, Mark P Thomas, Antony Galione

Chem Commun (Camb)· March 2014

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Roles and mechanisms of the CD38/cyclic adenosine diphosphate ribose/Ca(2+) signaling pathway.
Wenjie Wei, Richard Graeff, Jianbo Yue

World J Biol Chem· February 2014

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Determination of ADP-ribosyl cyclase activity, cyclic ADP-ribose, and nicotinic acid adenine dinucleotide phosphate in tissue extracts.
Richard M Graeff, Hon Cheung Lee

Methods Mol Biol· December 2013

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NAADP/TPC2/Ca(2+) Signaling Inhibits Autophagy.
Yingying Lu, Baixia Hao, Richard Graeff, Jianbo Yue

Commun Integr Biol· November 2013

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Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH.
Yingying Lu, Bai-Xia Hao, Richard Graeff, Connie W M Wong, Wu-Tian Wu

J Biol Chem· August 2013

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Increased CD38 expression in T cells and circulating anti-CD38 IgG autoantibodies differentially correlate with distinct cytokine profiles and disease activity in systemic lupus erythematosus patients.
Esther J Pavón, Esther Zumaquero, Antonio Rosal-Vela, Keng-Meng Khoo, Daniela Cerezo-Wallis, Richard Graeff

Cytokine· May 2013

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Identification of ADP-ribosylation sites of CD38 mutants by precursor ion scanning mass spectrometry.
Hong Jiang, Robert Sherwood, Sheng Zhang, Xuling Zhu, Qun Liu, Richard Graeff

Anal Biochem· February 2013

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Roles of cADPR and NAADP in pancreatic cells.
Yongjuan Zhao, Richard Graeff, Hon Cheung Lee

Acta Biochim Biophys Sin (Shanghai)· September 2012

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Structural studies of intermediates along the cyclization pathway of Aplysia ADP-ribosyl cyclase.
Masayo Kotaka, Richard Graeff, Zhe Chen, Li He Zhang, Hon Cheung Lee

J Mol Biol· January 2012

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The role of autoimmunologists in investigating and treating autoimmune disorders.
Arpad Zsigmond Barabas, Chad Douglas Cole, Richard Milton Graeff, Rene Lafreniere, Donald Mackay Weir

Autoimmun Rev· January 2011

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Dynamic conformations of the CD38-mediated NAD cyclization captured in a single crystal.
HongMin Zhang, Richard Graeff, Zhe Chen, Liangren Zhang, Lihe Zhang

J Mol Biol· January 2011

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Modified vaccination technique for prophylactic and therapeutic applications to combat endogenous antigen-induced disorders.
Arpad Z Barabas, Chad D Cole, Arpad D Barabas, Richard M Graeff, Rene Lafreniere

Scand J Immunol· March 2010

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Comment on "The Arabidopsis circadian clock incorporates a cADPR-based feedback loop".
Xiaodong Xu, Richard Graeff, Qiguang Xie, Karen L Gamble, Tetsuya Mori

Science· October 2009

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