Publications by authors named "Robert Ardecky"

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Targeting of a Bile Acid Receptor, Takeda G Protein Receptor 5 [TGR5], by a Novel First-in-Class Competitive Antagonist, SBI-364, Diminishes Hepatic and Renal Cystogenesis in Polycystic Liver and Kidney Disease.
Tetyana Masyuk, Anatoliy Masyuk, Christy Trussoni, Maria Lorenzo-Pisarello, Robert Ardecky

ACS Pharmacol Transl Sci· July 2025

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Structure-activity relationships of thiadiazole agonists of the human secretin receptor.
Robert Ardecky, Daniela G Dengler, Kaleeckal G Harikumar, Mathew M Abelman, Jiwen Zou

SLAS Discov· September 2024

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Discovery of novel furanylbenzamide inhibitors that target oncogenic tyrosine phosphatase SHP2 in leukemia cells.
Dhanya Raveendra-Panickar, Darren Finlay, Fabiana Izidro Layng, Lester J Lambert, Maria Celeridad, Robert Ardecky

J Biol Chem· January 2022

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Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase.
Stephanie M Stanford, Michael A Diaz, Robert J Ardecky, Jiwen Zou, Tarmo Roosild

J Med Chem· May 2021

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Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth.
Shinji Iizuka, Manuela Quintavalle, Jose C Navarro, Kyle P Gribbin, Robert J Ardecky

Cancer Res· March 2021

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Discovery of small molecule positive allosteric modulators of the secretin receptor.
Daniela G Dengler, Kaleeckal G Harikumar, Sirkku Pollari, Qing Sun, Brock T Brown, Robert Ardecky

Biochem Pharmacol· March 2021

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Development of a Testing Funnel for Identification of Small-Molecule Modulators Targeting Secretin Receptors.
Daniela G Dengler, Qing Sun, John Holleran, Sirkku Pollari, Jannis Beutel, Robert Ardecky

SLAS Discov· January 2021

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Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.
Anthony B Pinkerton, Satyamaheshwar Peddibhotla, Fusayo Yamamoto, Lauren M Slosky, Yushi Bai, Robert J Ardecky

J Med Chem· September 2019

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TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling.
Tatyana V Masyuk, Anatoliy I Masyuk, Maria Lorenzo Pisarello, Brynn N Howard, Bing Q Huang, Robert J Ardecky

Hepatology· October 2017

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Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis.
Kate Welsh, Snezana Milutinovic, Robert J Ardecky, Marcos Gonzalez-Lopez, Santhi Reddy Ganji

PLoS One· August 2017

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Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Stephanie M Stanford, Alexander E Aleshin, Vida Zhang, Robert J Ardecky, Michael P Hedrick

Nat Chem Biol· June 2017

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Benzodiazepinone derivatives protect against endoplasmic reticulum stress-mediated cell death in human neuronal cell lines.
Haixia Zou, Allison S Limpert, Jiwen Zou, Anna Dembo, Pooi-San Lee, Robert Ardecky

ACS Chem Neurosci· March 2015

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Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.
Robert J Ardecky, Ekaterina V Bobkova, Tina Kiffer-Moreira, Brock Brown, Santhi Ganji

Bioorg Med Chem Lett· February 2014

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Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs.
Darren Finlay, Mitchell Vamos, Marcos González-López, Robert J Ardecky, Santhi Reddy Ganji

Mol Cancer Ther· January 2014

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Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
Robert J Ardecky, Kate Welsh, Darren Finlay, Pooi San Lee, Marcos González-López

Bioorg Med Chem Lett· July 2013

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Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP.
Mitchell Vamos, Kate Welsh, Darren Finlay, Pooi San Lee, Peter D Mace, Robert J Ardecky

ACS Chem Biol· April 2013

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Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
Marcos González-López, Kate Welsh, Darren Finlay, Robert J Ardecky, Santhi Reddy Ganji

Bioorg Med Chem Lett· July 2011

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