Publications by authors named "Robert Barbuch"

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The relative contributions of CYP3A4 and CYP3A5 to the metabolism of vinorelbine.
Ariel R Topletz, Jennifer B Dennison, Robert J Barbuch, Chad E Hadden, Stephen D Hall

Drug Metab Dispos· September 2013

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Pharmacokinetics, metabolism, and excretion of the glycogen synthase kinase-3 inhibitor LY2090314 in rats, dogs, and humans: a case study in rapid clearance by extensive metabolism with low circulating metabolite exposure.
Maciej J Zamek-Gliszczynski, Trent L Abraham, Jeffrey J Alberts, Palaniappan Kulanthaivel, Kimberley A Jackson, Robert J Barbuch

Drug Metab Dispos· April 2013

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Characterization of a mutation that results in independence of oxidosqualene cyclase (Erg7) activity from the downstream 3-ketoreductase (Erg27) in the yeast ergosterol biosynthetic pathway.
Jacob V Layer, Brett M Barnes, Yuji Yamasaki, Robert Barbuch, Liangtao Li

Biochim Biophys Acta· February 2013

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The fate of 4-hydroxycarbazole metabolite: metabolism and carcinogenicity assessment of a β-adrenergic receptor modulator containing carbazole structure.
Minxia M He, Tao Ji, Robert J Barbuch, Kristina Campanale, Ron Lantz

Xenobiotica· December 2011

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Metabolism of LY654322, a growth hormone secretagogue, to an unusual diimidazopyridine metabolite.
Anthony G Borel, Timothy M Jones, Robert J Barbuch, David A Jackson, Palaniappan Kulanthaivel

Drug Metab Dispos· May 2011

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Disposition and metabolism of semagacestat, a {gamma}-secretase inhibitor, in humans.
Ping Yi, Chad Hadden, Palaniappan Kulanthaivel, Nathan Calvert, William Annes, Robert J Barbuch

Drug Metab Dispos· April 2010

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A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus.
Sven D Willger, Srisombat Puttikamonkul, Kwang-Hyung Kim, James B Burritt, Nora Grahl, Robert Barbuch

PLoS Pathog· November 2008

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Apparent high CYP3A5 expression is required for significant metabolism of vincristine by human cryopreserved hepatocytes.
Jennifer B Dennison, Michael A Mohutsky, Robert J Barbuch, Steven A Wrighton, Stephen D Hall

J Pharmacol Exp Ther· October 2008

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Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes.
Adam L Hughes, David W Powell, Martin Bard, James Eckstein, Robert Barbuch

Cell Metab· February 2007

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Synthetically lethal interactions involving loss of the yeast ERG24: the sterol C-14 reductase gene.
M Shah Alam Bhuiyan, James Eckstein, Robert Barbuch, Martin Bard

Lipids· February 2007

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Disposition of [14C]ruboxistaurin in humans.
Jennifer L Burkey, Kristina M Campanale, Robert Barbuch, Douglas O'Bannon, James Rash

Drug Metab Dispos· November 2006

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Selective metabolism of vincristine in vitro by CYP3A5.
Jennifer B Dennison, Palaniappan Kulanthaivel, Robert J Barbuch, Jamie L Renbarger, William J Ehlhardt

Drug Metab Dispos· August 2006

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Cumulative mutations affecting sterol biosynthesis in the yeast Saccharomyces cerevisiae result in synthetic lethality that is suppressed by alterations in sphingolipid profiles.
Martin Valachovic, Bart M Bareither, M Shah Alam Bhuiyan, James Eckstein, Robert Barbuch

Genetics· August 2006

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In vivo metabolism of [14C]ruboxistaurin in dogs, mice, and rats following oral administration and the structure determination of its metabolites by liquid chromatography/mass spectrometry and NMR spectroscopy.
Robert J Barbuch, Kristina Campanale, Chad E Hadden, Milton Zmijewski, Ping Yi

Drug Metab Dispos· February 2006

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Sterol uptake in Candida glabrata: rescue of sterol auxotrophic strains.
Martin Bard, Aaron M Sturm, Charles A Pierson, Shaleak Brown, Kristina M Rogers, Robert Barbuch

Diagn Microbiol Infect Dis· August 2005

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Selective reduction of N-oxides to amines: application to drug metabolism.
Palaniappan Kulanthaivel, Robert J Barbuch, Rita S Davidson, Ping Yi, Gregory A Rener

Drug Metab Dispos· September 2004

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Genome-wide expression profiling reveals genes associated with amphotericin B and fluconazole resistance in experimentally induced antifungal resistant isolates of Candida albicans.
Katherine S Barker, Sarah Crisp, Nathan Wiederhold, Russell E Lewis, Bart Bareither, Robert Barbuch

J Antimicrob Chemother· August 2004

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Characterization of dark liver pigment observed in rats after subchronic dosing of the beta3-adrenergic receptor agonist LY368842.
Minxia M He, Robert J Barbuch, Trent L Abraham, Thomas J Lindsay, David A Jackson

Chem Res Toxicol· July 2003

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Disposition and metabolic fate of atomoxetine hydrochloride: pharmacokinetics, metabolism, and excretion in the Fischer 344 rat and beagle dog.
Edward L Mattiuz, G Douglas Ponsler, Robert J Barbuch, Paul G Wood, John H Mullen

Drug Metab Dispos· January 2003

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