Publications by authors named "Robert Fridell"

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Preclinical virology profiles of the HIV-1 capsid inhibitors VH4004280 and VH4011499.
Chunfu Wang, Haichang Huang, Lourdes Valera, Kyle Parcella, Christiana Iwuagwu, Robert A Fridell

Antimicrob Agents Chemother· October 2025

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The HIV-1 Capsid-Targeted Inhibitor GSK878 Alters Selection of Target Sites for HIV DNA Integration.
Kaitlin A Marquis, John Everett, Adrian Cantu, Alexander McFarland, Scott Sherrill-Mix, Robert A Fridell

AIDS Res Hum Retroviruses· February 2024

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Antiviral Properties of HIV-1 Capsid Inhibitor GSK878.
Chunfu Wang, Haichang Huang, Kirsten Mallon, Lourdes Valera, Kyle Parcella, Robert A Fridell

Antimicrob Agents Chemother· May 2023

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Potent Long-Acting Inhibitors Targeting the HIV-1 Capsid Based on a Versatile Quinazolin-4-one Scaffold.
Eric P Gillis, Kyle Parcella, Michael Bowsher, James H Cook, Christiana Iwuagwu, Robert Fridell

J Med Chem· February 2023

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Impact of Integrase Sequences from HIV-1 Subtypes A6/A1 on the Potency of Cabotegravir or Rilpivirine.
Jerry L Jeffrey, Marty St Clair, Ping Wang, Chunfu Wang, Zhufang Li, Robert Fridell

Antimicrob Agents Chemother· March 2022

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Synergistic Activity of Combined NS5A Inhibitors.
Donald R O'Boyle, Peter T Nower, Min Gao, Robert Fridell, Chunfu Wang

Antimicrob Agents Chemother· December 2015

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Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A.
Jin-Hua Sun, Donald R O'Boyle, Robert A Fridell, David R Langley, Chunfu Wang

Nature· November 2015

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Comparison of daclatasvir resistance barriers on NS5A from hepatitis C virus genotypes 1 to 6: implications for cross-genotype activity.
Chunfu Wang, Lingling Jia, Donald R O'Boyle, Jin-Hua Sun, Karen Rigat, Robert A Fridell

Antimicrob Agents Chemother· September 2014

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Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons.
Makonen Belema, Van N Nguyen, Jeffrey L Romine, Denis R St Laurent, Omar D Lopez, Robert A Fridell

J Med Chem· March 2014

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Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir.
Makonen Belema, Van N Nguyen, Carol Bachand, Dan H Deon, Jason T Goodrich, Robert A Fridell

J Med Chem· March 2014

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Discovery and development of hepatitis C virus NS5A replication complex inhibitors.
Makonen Belema, Omar D Lopez, John A Bender, Jeffrey L Romine, Denis R St Laurent, Robert A Fridell

J Med Chem· March 2014

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A 96-well based analysis of replicon elimination with the HCV NS5A replication complex inhibitor daclatasvir.
Donald R O'Boyle, Peter T Nower, Jin-Hua Sun, Robert Fridell, Chunfu Wang

J Virol Methods· October 2013

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Resistance analysis of hepatitis C virus genotype 1 prior treatment null responders receiving daclatasvir and asunaprevir.
Fiona McPhee, Dennis Hernandez, Fei Yu, Joseph Ueland, Aaron Monikowski, Robert Fridell

Hepatology· September 2013

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Characterizations of HCV NS5A replication complex inhibitors.
Donald R O'Boyle Ii, Jin-Hua Sun, Peter T Nower, Julie A Lemm, Robert A Fridell

Virology· September 2013

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HCV NS5A replication complex inhibitors. Part 5: discovery of potent and pan-genotypic glycinamide cap derivatives.
Makonen Belema, Van N Nguyen, Denis R St Laurent, Omar D Lopez, Yuping Qiu, Robert A Fridell

Bioorg Med Chem Lett· August 2013

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Persistence of resistant variants in hepatitis C virus-infected patients treated with the NS5A replication complex inhibitor daclatasvir.
Chunfu Wang, Jin-Hua Sun, Donald R O'Boyle, Peter Nower, Lourdes Valera, Robert A Fridell

Antimicrob Agents Chemother· May 2013

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Reply: To PMID 22234905.
Jin-Hua Sun, Min Gao, Susan Roberts, Robert Fridell

Hepatology· May 2013

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Intragenic complementation of hepatitis C virus NS5A RNA replication-defective alleles.
Robert A Fridell, Lourdes Valera, Dike Qiu, Melissa J Kirk, Chunfu Wang

J Virol· February 2013

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HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologies.
Omar D Lopez, Van N Nguyen, Denis R St Laurent, Makonen Belema, Michael H Serrano-Wu, Robert A Fridell

Bioorg Med Chem Lett· February 2013

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In vitro activity of daclatasvir on hepatitis C virus genotype 3 NS5A.
Chunfu Wang, Lourdes Valera, Lingling Jia, Melissa J Kirk, Min Gao, Robert A Fridell

Antimicrob Agents Chemother· January 2013

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Impact of a baseline polymorphism on the emergence of resistance to the hepatitis C virus nonstructural protein 5A replication complex inhibitor, BMS-790052.
Jin-Hua Sun, Donald R O'Boyle Ii, Yan Zhang, Chunfu Wang, Peter Nower, Robert A Fridell

Hepatology· June 2012

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Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: potent allosteric inhibitors of the hepatitis C virus NS5B polymerase.
Min Ding, Feng He, Thomas W Hudyma, Xiaofan Zheng, Michael A Poss, Robert A Fridell

Bioorg Med Chem Lett· April 2012

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In vitro activity of BMS-790052 on hepatitis C virus genotype 4 NS5A.
Chunfu Wang, Lingling Jia, Haichang Huang, Dike Qiu, Lourdes Valera, Robert A Fridell

Antimicrob Agents Chemother· March 2012

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Hepatitis C virus RNA elimination and development of resistance in replicon cells treated with BMS-790052.
Chunfu Wang, Haichang Huang, Lourdes Valera, Jin-Hua Sun, Donald R O'Boyle, Robert A Fridell

Antimicrob Agents Chemother· March 2012

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Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations.
Robert A Fridell, Chunfu Wang, Jin-Hua Sun, Donald R O'Boyle, Peter Nower

Hepatology· December 2011

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