Publications by authors named "Robert Knabb"

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From basic science to life-saving therapy: the rationale, and drug discovery efforts that led to the direct factor Xa inhibitor eliquis.
Robert M Knabb, Ruth R Wexler

J Thromb Thrombolysis· August 2021

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Discussion of talks from the symposium: Factor X: From thrombokinase to oral anti-coagulants and beyond.
Leonard M Milstone, Craig Jackson, Richard C Becker, Rodney Camire, Robert Knabb

J Thromb Thrombolysis· August 2021

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First-in-human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS-962212, a direct, reversible, small molecule factor XIa inhibitor in non-Japanese and Japanese healthy subjects.
Vidya Perera, Joseph M Luettgen, Zhaoqing Wang, Charles E Frost, Cynthia Yones, Robert M Knabb

Br J Clin Pharmacol· May 2018

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Apixaban Versus Warfarin for Mechanical Heart Valve Thromboprophylaxis in a Swine Aortic Heterotopic Valve Model.
Patrick A Lester, Dawn M Coleman, Jose A Diaz, Tatum O Jackson, Angela E Hawley, Robert M Knabb

Arterioscler Thromb Vasc Biol· May 2017

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Development of apixaban: a novel anticoagulant for prevention of stroke in patients with atrial fibrillation.
Michael S Hanna, Puneet Mohan, Robert Knabb, Elora Gupta, Charles Frost

Ann N Y Acad Sci· November 2014

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Orally bioavailable factor Xa inhibitors containing alpha-substituted gem-dimethyl P4 moieties.
Michael J Orwat, Jennifer X Qiao, Kan He, Alan R Rendina, Joseph M Luettgen, Robert M Knabb

Bioorg Med Chem Lett· August 2014

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Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors.
Xiaojun Zhang, Wen Jiang, Swanee Jacutin-Porte, Peter W Glunz, Yan Zou, Robert M Knabb

ACS Med Chem Lett· February 2014

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A novel prothrombin time assay for assessing the anticoagulant activity of oral factor Xa inhibitors.
Yu Chen Barrett, Zhaoqing Wang, Robert M Knabb

Clin Appl Thromb Hemost· September 2013

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Nonbenzamidine acylsulfonamide tissue factor-factor VIIa inhibitors.
Peter W Glunz, Xiaojun Zhang, Yan Zou, Indawati Delucca, Alexandra H Nirschl, Robert Knabb

Bioorg Med Chem Lett· September 2013

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Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor.
E Scott Priestley, Indawati De Lucca, Jinglan Zhou, Jiacheng Zhou, Eddine Saiah, Robert M Knabb

Bioorg Med Chem Lett· April 2013

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Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF-FVIIa inhibitors.
Xiaojun Zhang, Peter W Glunz, Wen Jiang, Aaron Schmitt, Makenzie Newman, Robert M Knabb

Bioorg Med Chem Lett· March 2013

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The emergence of factor Xa inhibitors for the treatment of cardiovascular diseases: a patent review.
Donald J P Pinto, Jennifer X Qiao, Robert M Knabb

Expert Opin Ther Pat· June 2012

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Apixaban versus enoxaparin for thromboprophylaxis in medically ill patients.
Samuel Z Goldhaber, Alain Leizorovicz, Ajay K Kakkar, Sylvia K Haas, Geno Merli, Robert M Knabb

N Engl J Med· December 2011

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Preclinical pharmacokinetics and pharmacodynamics of apixaban, a potent and selective factor Xa inhibitor.
Kan He, Joseph M Luettgen, Donglu Zhang, Bing He, James E Grace, Robert M Knabb

Eur J Drug Metab Pharmacokinet· September 2011

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Apixaban inhibition of factor Xa: Microscopic rate constants and inhibition mechanism in purified protein systems and in human plasma.
Joseph M Luettgen, Robert M Knabb, Kan He, Donald J P Pinto, Alan R Rendina

J Enzyme Inhib Med Chem· August 2011

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Apixaban decreases coagulation activity in patients with acute deep-vein thrombosis.
Yu Chen Barrett, Jessie Wang, Robert Knabb, Puneet Mohan

Thromb Haemost· January 2011

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Factor Xa inhibitors: next-generation antithrombotic agents.
Donald J P Pinto, Joanne M Smallheer, Daniel L Cheney, Robert M Knabb, Ruth R Wexler

J Med Chem· September 2010

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BMS-593214, an active site-directed factor VIIa inhibitor: enzyme kinetics, antithrombotic and antihaemostatic studies.
Pancras C Wong, Joseph M Luettgen, Alan R Rendina, Charles A Kettner, Baomin Xin, Robert M Knabb

Thromb Haemost· August 2010

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Phenyltriazolinones as potent factor Xa inhibitors.
Mimi L Quan, Donald J P Pinto, Karen A Rossi, Steven Sheriff, Richard S Alexander, Robert M Knabb

Bioorg Med Chem Lett· February 2010

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Comparative metabolism of 14C-labeled apixaban in mice, rats, rabbits, dogs, and humans.
Donglu Zhang, Kan He, Nirmala Raghavan, Lifei Wang, James Mitroka, Robert M Knabb

Drug Metab Dispos· August 2009

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Sulfation of o-demethyl apixaban: enzyme identification and species comparison.
Lifei Wang, Nirmala Raghavan, Kan He, Joseph M Luettgen, W Griffith Humphreys, Robert M Knabb

Drug Metab Dispos· April 2009

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Highly efficacious factor Xa inhibitors containing alpha-substituted phenylcycloalkyl P4 moieties.
Jennifer X Qiao, Sarah R King, Kan He, Pancras C Wong, Alan R Rendina, Robert M Knabb

Bioorg Med Chem Lett· January 2009

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Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl P4 moieties: discovery of novel, highly potent inhibitors of Factor Xa.
Jennifer X Qiao, Daniel L Cheney, Richard S Alexander, Angela M Smallwood, Sarah R King, Robert M Knabb

Bioorg Med Chem Lett· July 2008

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Structure-activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties.
James R Corte, Tianan Fang, Donald J P Pinto, Wei Han, Zilun Hu, Robert M Knabb

Bioorg Med Chem Lett· May 2008

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Sulfonamidolactam inhibitors of coagulation factor Xa.
Joanne M Smallheer, Shuaige Wang, Mia L Laws, Suanne Nakajima, Zilun Hu, Robert M Knabb

Bioorg Med Chem Lett· April 2008

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