Publications by authors named "Robert Lyon"

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Reversible Chemical Modification of Antibody Effector Function Mitigates Unwanted Systemic Immune Activation.
Philip N Moquist, Xinqun Zhang, Chris I Leiske, Nicole M-L Eng-Duncan, Weiping Zeng, Robert Lyon

Bioconjug Chem· June 2024

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SGN-B6A: A New Vedotin Antibody-Drug Conjugate Directed to Integrin Beta-6 for Multiple Carcinoma Indications.
Robert P Lyon, Mechthild Jonas, Christopher Frantz, Esther S Trueblood, Roma Yumul

Mol Cancer Ther· December 2023

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Development and Optimization of a Machine-Learning Prediction Model for Acute Desquamation After Breast Radiation Therapy in the Multicenter REQUITE Cohort.
Mahmoud Aldraimli, Sarah Osman, Diana Grishchuck, Samuel Ingram, Robert Lyon

Adv Radiat Oncol· January 2022

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A data science approach for early-stage prediction of Patient's susceptibility to acute side effects of advanced radiotherapy.
Mahmoud Aldraimli, Daniele Soria, Diana Grishchuck, Samuel Ingram, Robert Lyon

Comput Biol Med· August 2021

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Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy.
Yan Liang, Robert C Lyon, Jason Pellman, William H Bradford, Stephan Lange

J Clin Invest· June 2021

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Improving Antibody-Tubulysin Conjugates through Linker Chemistry and Site-Specific Conjugation.
Joseph Z Hamilton, Thomas A Pires, Jamie A Mitchell, Julia H Cochran, Kim K Emmerton, Robert P Lyon

ChemMedChem· April 2021

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Novel Auristatins with High Bystander and Cytotoxic Activities in Drug Efflux-positive Tumor Models.
Philip N Moquist, Tim D Bovee, Andrew B Waight, Jamie A Mitchell, Jamie B Miyamoto, Robert P Lyon

Mol Cancer Ther· February 2021

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Structure-activity relationships of tubulysin analogues.
Joel R Courter, Joseph Z Hamilton, Nathaniel R Hendrick, Margo Zaval, Andrew B Waight, Robert P Lyon

Bioorg Med Chem Lett· July 2020

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Reducing the antigen-independent toxicity of antibody-drug conjugates by minimizing their non-specific clearance through PEGylation.
Jessica K Simmons, Patrick J Burke, Julia H Cochran, Paul G Pittman, Robert P Lyon

Toxicol Appl Pharmacol· April 2020

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An in Vitro Assay Using Cultured Kupffer Cells Can Predict the Impact of Drug Conjugation on in Vivo Antibody Pharmacokinetics.
David W Meyer, Lauren B Bou, Sara Shum, Mechthild Jonas, Martha E Anderson, Robert P Lyon

Mol Pharm· March 2020

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A coiled-coil masking domain for selective activation of therapeutic antibodies.
Vivian H Trang, Xinqun Zhang, Roma C Yumul, Weiping Zeng, Ivan J Stone, Robert P Lyon

Nat Biotechnol· July 2019

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Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody-Drug Conjugates.
Christopher S Neumann, Kathleen C Olivas, Martha E Anderson, Julia H Cochran, Steven Jin, Robert P Lyon

Mol Cancer Ther· December 2018

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Drawing lessons from the clinical development of antibody-drug conjugates.
Robert Lyon

Drug Discov Today Technol· December 2018

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Glucuronide-Linked Antibody-Tubulysin Conjugates Display Activity in MDR and Heterogeneous Tumor Models.
Patrick J Burke, Joseph Z Hamilton, Thomas A Pires, Holden W H Lai, Christopher I Leiske, Robert P Lyon

Mol Cancer Ther· August 2018

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Optimization of a PEGylated Glucuronide-Monomethylauristatin E Linker for Antibody-Drug Conjugates.
Patrick J Burke, Joseph Z Hamilton, Scott C Jeffrey, Joshua H Hunter, Svetlana O Doronina, Robert P Lyon

Mol Cancer Ther· January 2017

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Antibody-conjugated drug assay for protease-cleavable antibody-drug conjugates.
Russell J Sanderson, Nicole D Nicholas, Cassandra Baker Lee, Shawna Mae Hengel, Robert P Lyon

Bioanalysis· September 2016

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Desmosomal junctions are necessary for adult sinus node function.
Valeria Mezzano, Yan Liang, Adam T Wright, Robert C Lyon, Emily Pfeiffer

Cardiovasc Res· August 2016

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Garra sindhi, a new species from the Jebel Samhan Nature Reserve in Oman (Teleostei: Cyprinidae).
Robert Gary Lyon, Matthias F Geiger, Jörg Freyhof

Zootaxa· August 2016

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The Methylene Alkoxy Carbamate Self-Immolative Unit: Utilization for the Targeted Delivery of Alcohol-Containing Payloads with Antibody-Drug Conjugates.
Robert V Kolakowski, Karl T Haelsig, Kim K Emmerton, Chris I Leiske, Jamie B Miyamoto, Robert P Lyon

Angew Chem Int Ed Engl· July 2016

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Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models.
Fu Li, Kim K Emmerton, Mechthild Jonas, Xinqun Zhang, Jamie B Miyamoto, Robert P Lyon

Cancer Res· May 2016

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Development of Novel Quaternary Ammonium Linkers for Antibody-Drug Conjugates.
Patrick J Burke, Joseph Z Hamilton, Thomas A Pires, Jocelyn R Setter, Joshua H Hunter, Robert P Lyon

Mol Cancer Ther· May 2016

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Functions of myosin light chain-2 (MYL2) in cardiac muscle and disease.
Farah Sheikh, Robert C Lyon, Ju Chen

Gene· September 2015

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Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index.
Robert P Lyon, Tim D Bovee, Svetlana O Doronina, Patrick J Burke, Joshua H Hunter

Nat Biotechnol· July 2015

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Mechanotransduction in cardiac hypertrophy and failure.
Robert C Lyon, Fabian Zanella, Jeffrey H Omens, Farah Sheikh

Circ Res· April 2015

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Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates.
Robert P Lyon, Jocelyn R Setter, Tim D Bovee, Svetlana O Doronina, Joshua H Hunter

Nat Biotechnol· October 2014

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