Publications by authors named "Robert Mecham"

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Elastin Regulation of Vasoreactivity in Resistance Arteries.
Claire A Ruddiman, Brooke L O'Donnell, Abigail Wolpe, Nyla Blagrove, Luke S Dunaway, Robert P Mecham

Hypertension· December 2025

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Loss of MFAP5 and Its Effect on Skin Homeostasis and Wound Healing.
Chen Han, Heidi Yuan, Timothy J Koh, Lin Chen, Robert P Mecham

FASEB J· December 2025

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Latent transforming growth factor binding protein-2 (LTBP2), an IPF biomarker of clinical decline, promotes TGF-beta signaling and lung fibrosis in mice.
Nicholas K Bodmer, Malay Choudhury, Haider Mirza, Suramamayi Pradhan, Yongjun Yin, Robert P Mecham

bioRxiv· August 2025

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Distinct Patterns of Smooth Muscle Phenotypic Modulation in Thoracic and Abdominal Aortic Aneurysms.
Chien-Jung Lin, Campbell Keating, Robyn Roth, Yasar Caliskan, Mustafa Nazzal, Robert P Mecham

J Cardiovasc Dev Dis· November 2024

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Constitutive Modeling of Mouse Arteries Suggests Changes in Directional Coupling and Extracellular Matrix Remodeling That Depend on Artery Type, Age, Sex, and Elastin Amounts.
Keshav A Kailash, Jie Z Hawes, Austin J Cocciolone, Matthew R Bersi, Robert P Mecham

J Biomech Eng· March 2024

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Multi-organ phenotypes in mice lacking latent TGFβ binding protein 2 (LTBP2).
Nicholas K Bodmer, Russell H Knutsen, Robyn A Roth, Ryan M Castile, Michael D Brodt, Robert P Mecham

Dev Dyn· February 2024

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Polarized localization of phosphatidylserine in the endothelium regulates Kir2.1.
Claire A Ruddiman, Richard Peckham, Melissa A Luse, Yen-Lin Chen, Maniselvan Kuppusamy, Robert P Mecham

JCI Insight· May 2023

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Progerin induces a phenotypic switch in vascular smooth muscle cells and triggers replication stress and an aging-associated secretory signature.
Nuria Coll-Bonfill, Urvashi Mahajan, Elena V Shashkova, Chien-Jung Lin, Robert P Mecham

Geroscience· April 2023

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Targeting Epidermal Growth Factor Receptor to Stimulate Elastic Matrix Regenerative Repair.
Simran Dayal, Thomas Broekelmann, Robert P Mecham, Anand Ramamurthi

Tissue Eng Part A· April 2023

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A new mouse model of elastin haploinsufficiency highlights the importance of elastin to vascular development and blood pressure regulation.
Bridget M Brengle, Michelle Lin, Robyn A Roth, Kara D Jones, Jessica E Wagenseil, Robert P Mecham

Matrix Biol· March 2023

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Author Correction: SVEP1 is an endogenous ligand for the orphan receptor PEAR1.
Jared S Elenbaas, Upasana Pudupakkam, Katrina J Ashworth, Chul Joo Kang, Ved Patel, Robert P Mecham

Nat Commun· March 2023

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SVEP1 is an endogenous ligand for the orphan receptor PEAR1.
Jared S Elenbaas, Upasana Pudupakkam, Katrina J Ashworth, Chul Joo Kang, Ved Patel, Robert P Mecham

Nat Commun· February 2023

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Inhibition of NOX1 Mitigates Blood Pressure Increases in Elastin Insufficiency.
Angela Troia, Russell H Knutsen, Carmen M Halabi, Daniela Malide, Zu Xi Yu, Robert P Mecham

Function (Oxf)· January 2023

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Increases in hydraulic conductance and solute permeability in a mouse model of ascending thoracic aortic aneurysm.
Christie L Crandall, Sean Y Kim, Jacob Rother, Vivian S Lee, Robert P Mecham

J Biomech· December 2022

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LTBP1 promotes fibrillin incorporation into the extracellular matrix.
Matthias Przyklenk, Veronika S Georgieva, Fabian Metzen, Sebastian Mostert, Birgit Kobbe, Robert P Mecham

Matrix Biol· June 2022

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Gene Silencing for Elastic Matrix Regenerative Repair.
Sarah Carney, Tom Broekelmann, Robert Mecham, Anand Ramamurthi

Tissue Eng Part A· March 2022

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JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency.
Jui M Dave, Raja Chakraborty, Aglaia Ntokou, Junichi Saito, Fatima Z Saddouk, Robert Mecham

J Clin Invest· March 2022

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Passive biaxial mechanical behavior of newborn mouse aorta with and without elastin.
Jungsil Kim, Austin J Cocciolone, Marius C Staiculescu, Robert P Mecham, Jessica E Wagenseil

J Mech Behav Biomed Mater· February 2022

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Vascular Smooth Muscle Cell Subpopulations and Neointimal Formation in Mouse Models of Elastin Insufficiency.
Chien-Jung Lin, Bridget M Hunkins, Robyn A Roth, Chieh-Yu Lin, Jessica E Wagenseil, Robert P Mecham

Arterioscler Thromb Vasc Biol· December 2021

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Deletion of type VIII collagen reduces blood pressure, increases carotid artery functional distensibility and promotes elastin deposition.
Amanda L Mohabeer, Jeffrey T Kroetsch, Meghan McFadden, Negin Khosraviani, Thomas J Broekelmann, Robert P Mecham

Matrix Biol Plus· December 2021

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Biological Preparation and Mechanical Technique for Determining Viscoelastic Properties of Zonular Fibers.
Juan Rodriguez, Matthew Reilly, Robert P Mecham, Steven Bassnett

J Vis Exp· December 2021

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Loss of Angiotensin II Type 2 Receptor Improves Blood Pressure in Elastin Insufficiency.
Michelle Lin, Robyn A Roth, Beth A Kozel, Robert P Mecham, Carmen M Halabi

Front Cardiovasc Med· November 2021

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Tissue-specific smooth muscle cell subtypes identified by transcriptional profiling.
Chien-Jung Lin, Robert P Mecham

Int J Biochem Cell Biol· October 2021

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Early Aberrant Angiogenesis Due to Elastic Fiber Fragmentation in Aortic Valve Disease.
Robert B Hinton, Amy L Juraszek, Amy M Opoka, Benjamin J Landis, J Michael Smith, Robert P Mecham

J Cardiovasc Dev Dis· June 2021

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SVEP1 is a human coronary artery disease locus that promotes atherosclerosis.
In-Hyuk Jung, Jared S Elenbaas, Arturo Alisio, Katherine Santana, Erica P Young, Robert P Mecham

Sci Transl Med· March 2021

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