Publications by authors named "Robert Saxton"

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Redirecting immune signaling with cytokine adaptors.
Gita C Abhiraman, Karsten D Householder, Grayson E Rodriguez, Caleb R Glassman, Robert A Saxton

Nat Commun· March 2025

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Large-scale mutational analysis identifies UNC93B1 variants that drive TLR-mediated autoimmunity in mice and humans.
Victoria E Rael, Julian A Yano, John P Huizar, Leianna C Slayden, Madeleine A Weiss, Robert A Saxton

J Exp Med· August 2024

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Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling.
Nathanael A Caveney, Grayson E Rodriguez, Christoph Pollmann, Thomas Meyer, Marta T Borowska, Robert A Saxton

Mol Cell· May 2024

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A structural blueprint for interleukin-21 signal modulation.
Gita C Abhiraman, Theodora U J Bruun, Nathanael A Caveney, Leon L Su, Robert A Saxton

Cell Rep· June 2023

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Structural basis of Janus kinase trans-activation.
Nathanael A Caveney, Robert A Saxton, Deepa Waghray, Caleb R Glassman, Naotaka Tsutsumi

Cell Rep· March 2023

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Structural insights into the mechanism of leptin receptor activation.
Robert A Saxton, Nathanael A Caveney, Maria Dolores Moya-Garzon, Karsten D Householder, Grayson E Rodriguez

Nat Commun· March 2023

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Emerging principles of cytokine pharmacology and therapeutics.
Robert A Saxton, Caleb R Glassman, K Christopher Garcia

Nat Rev Drug Discov· January 2023

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Cryo-EM structure of the IL-10 receptor complex provides a blueprint for ligand engineering.
Robert A Saxton, K Christopher Garcia

FEBS J· December 2022

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Structure of the nutrient-sensing hub GATOR2.
Max L Valenstein, Kacper B Rogala, Pranav V Lalgudi, Edward J Brignole, Xin Gu, Robert A Saxton

Nature· July 2022

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Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation.
Caleb R Glassman, Naotaka Tsutsumi, Robert A Saxton, Patrick J Lupardus, Kevin M Jude

Science· April 2022

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The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design.
Robert A Saxton, Lukas T Henneberg, Marco Calafiore, Leon Su, Kevin M Jude

Immunity· April 2021

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Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10.
Robert A Saxton, Naotaka Tsutsumi, Leon L Su, Gita C Abhiraman, Kritika Mohan

Science· March 2021

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Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Kritika Mohan, George Ueda, Ah Ram Kim, Kevin M Jude, Jorge A Fallas, Robert A Saxton

Science· May 2019

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Dimerization quality control ensures neuronal development and survival.
Elijah L Mena, Rachel A S Kjolby, Robert A Saxton, Achim Werner, Brandon G Lew

Science· October 2018

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SAMTOR is an -adenosylmethionine sensor for the mTORC1 pathway.
Xin Gu, Jose M Orozco, Robert A Saxton, Kendall J Condon, Grace Y Liu

Science· November 2017

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mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini

Cell· April 2017

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mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini

Cell· March 2017

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The apo-structure of the leucine sensor Sestrin2 is still elusive.
Robert A Saxton, Kevin E Knockenhauer, Thomas U Schwartz, David M Sabatini

Sci Signal· September 2016

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Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.
Robert A Saxton, Lynne Chantranupong, Kevin E Knockenhauer, Thomas U Schwartz, David M Sabatini

Nature· August 2016

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The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.
Lynne Chantranupong, Sonia M Scaria, Robert A Saxton, Melanie P Gygi, Kuang Shen

Cell· March 2016

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Sestrin2 is a leucine sensor for the mTORC1 pathway.
Rachel L Wolfson, Lynne Chantranupong, Robert A Saxton, Kuang Shen, Sonia M Scaria

Science· January 2016

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Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.
Robert A Saxton, Kevin E Knockenhauer, Rachel L Wolfson, Lynne Chantranupong, Michael E Pacold

Science· January 2016

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Dehydrogenation of n-Alkanes by Solid-Phase Molecular Pincer-Iridium Catalysts. High Yields of α-Olefin Product.
Akshai Kumar, Tian Zhou, Thomas J Emge, Oleg Mironov, Robert J Saxton

J Am Chem Soc· August 2015

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The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.
Lynne Chantranupong, Rachel L Wolfson, Jose M Orozco, Robert A Saxton, Sonia M Scaria

Cell Rep· October 2014

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Productive chloroarene C-cl bond activation: palladium/phosphine-catalyzed methods for oxidation of alcohols and hydrodechlorination of chloroarenes.
Xiaohong Bei, Alfred Hagemeyer, Anthony Volpe, Robert Saxton, Howard Turner

J Org Chem· December 2004

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