Publications by authors named "Roberta De Simone"

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Maternal stressors disrupt mouse placental proteome and fetal brain development in a sex-specific fashion through inflammation and oxidative stress.
Chiara Musillo, Maria Antonietta Ajmone-Cat, Roberta De Simone, Roberta Tassinari, Francesca Maranghi

Mol Psychiatry· November 2025

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Microglia depletion in a mouse model of prenatal and postnatal immune activation.
Naomi Ciano Albanese, Ignacio Del Castillo, Giulia Ragaglia, Giulia Castellano, Maria Antonietta Ajmone-Cat, Roberta De Simone

Brain Behav Immun· October 2025

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Insights into the Sex-Related Effects of Dietary Polyphenols and Metabolic Disruptors on Inflammatory and (Neuro) Endocrine Pathways in Obesity: The HEAL Project.
Carmela Santangelo, Beatrice Scazzocchio, Rosaria Varì, Maria Antonietta Ajmone-Cat, Alessia Tammaro, Roberta De Simone

Nutrients· October 2024

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Effects of a gut-selective integrin-targeted therapy in male mice exposed to early immune activation, a model for the study of autism spectrum disorder.
Alessia Butera, Roberta De Simone, Rosa Luisa Potenza, Massimo Sanchez, Monica Armida

Brain Behav Immun· January 2024

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Bdnf-Nrf-2 crosstalk and emotional behavior are disrupted in a sex-dependent fashion in adolescent mice exposed to maternal stress or maternal obesity.
Chiara Musillo, Kerstin C Creutzberg, Barbara Collacchi, Maria Antonietta Ajmone-Cat, Roberta De Simone

Transl Psychiatry· December 2023

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Maternal immune activation induces autism-like changes in behavior, neuroinflammatory profile and gut microbiota in mouse offspring of both sexes.
Anna Maria Tartaglione, Annacandida Villani, Maria Antonietta Ajmone-Cat, Luisa Minghetti, Laura Ricceri, Roberta De Simone

Transl Psychiatry· September 2022

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Inflammatory Signatures of Maternal Obesity as Risk Factors for Neurodevelopmental Disorders: Role of Maternal Microbiota and Nutritional Intervention Strategies.
Francesca Cirulli, Roberta De Simone, Chiara Musillo, Maria Antonietta Ajmone-Cat, Alessandra Berry

Nutrients· July 2022

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Critical Role of Maternal Selenium Nutrition in Neurodevelopment: Effects on Offspring Behavior and Neuroinflammatory Profile.
Maria Antonietta Ajmone-Cat, Roberta De Simone, Anna Maria Tartaglione, Antonella Di Biase, Rita Di Benedetto

Nutrients· April 2022

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Repurposing Dipyridamole in Niemann Pick Type C Disease: A Proof of Concept Study.
Rita Pepponi, Roberta De Simone, Chiara De Nuccio, Sergio Visentin, Andrea Matteucci

Int J Mol Sci· March 2022

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Systemic depletion of histone macroH2A1.1 boosts hippocampal synaptic plasticity and social behavior in mice.
Valentina Chiodi, Maria Rosaria Domenici, Tommaso Biagini, Roberta De Simone, Anna Maria Tartaglione

FASEB J· August 2021

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Integration of Multiple Platforms for the Analysis of Multifluorescent Marking Technology Applied to Pediatric GBM and DIPG.
Giulia Pericoli, Stefania Petrini, Ezio Giorda, Roberta Ferretti, Maria Antonietta Ajmone-Cat, Roberta De Simone

Int J Mol Sci· September 2020

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Beneficial Effects of Fingolimod on Social Interaction, CNS and Peripheral Immune Response in the BTBR Mouse Model of Autism.
Roberta De Simone, Alessia Butera, Monica Armida, Antonella Pezzola, Monica Boirivant

Neuroscience· May 2020

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Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis.
Rosa Luisa Potenza, Roberta De Simone, Monica Armida, Valentina Mazziotti, Antonella Pèzzola

Neurotherapeutics· October 2016

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Glycogen synthase kinase 3 is part of the molecular machinery regulating the adaptive response to LPS stimulation in microglial cells.
Maria Antonietta Ajmone-Cat, Maria Cristina D'Urso, Giorgia di Blasio, Maria Stefania Brignone, Roberta De Simone

Brain Behav Immun· July 2016

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The mitochondrial uncoupling protein-2 is a master regulator of both M1 and M2 microglial responses.
Roberta De Simone, Maria Antonietta Ajmone-Cat, Manuela Pandolfi, Antonietta Bernardo, Chiara De Nuccio

J Neurochem· October 2015

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The nuclear receptor peroxisome proliferator-activated receptor-γ promotes oligodendrocyte differentiation through mechanisms involving mitochondria and oscillatory Ca2+ waves.
Antonietta Bernardo, Roberta De Simone, Chiara De Nuccio, Sergio Visentin, Luisa Minghetti

Biol Chem· December 2013

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Microglial polarization and plasticity: evidence from organotypic hippocampal slice cultures.
Maria Antonietta Ajmone-Cat, Melissa Mancini, Roberta De Simone, Piera Cilli, Luisa Minghetti

Glia· October 2013

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Branched-chain amino acids influence the immune properties of microglial cells and their responsiveness to pro-inflammatory signals.
Roberta De Simone, Federica Vissicchio, Cecilia Mingarelli, Chiara De Nuccio, Sergio Visentin

Biochim Biophys Acta· May 2013

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Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells.
Maria Antonietta Ajmone-Cat, Maria Lavinia Salvatori, Roberta De Simone, Melissa Mancini, Stefano Biagioni

J Neurosci Res· March 2012

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Peroxisome proliferator-activated receptor γ agonists accelerate oligodendrocyte maturation and influence mitochondrial functions and oscillatory Ca(2+) waves.
Chiara De Nuccio, Antonietta Bernardo, Roberta De Simone, Enrico Mancuso, Valerio Magnaghi

J Neuropathol Exp Neurol· October 2011

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TGF-β and LPS modulate ADP-induced migration of microglial cells through P2Y1 and P2Y12 receptor expression.
Roberta De Simone, Cristina Elena Niturad, Chiara De Nuccio, Maria Antonietta Ajmone-Cat, Sergio Visentin

J Neurochem· October 2010

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Microglial activation in chronic neurodegenerative diseases: roles of apoptotic neurons and chronic stimulation.
Luisa Minghetti, Maria Antonietta Ajmone-Cat, Maria Anna De Berardinis, Roberta De Simone

Brain Res Brain Res Rev· April 2005

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Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures.
Roberta De Simone, Maria Antonietta Ajmone-Cat, Daniela Carnevale, Luisa Minghetti

J Neuroinflammation· January 2005

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Cognitive and neurological deficits induced by early and prolonged basal forebrain cholinergic hypofunction in rats.
Laura Ricceri, Luisa Minghetti, Anna Moles, Patrizia Popoli, Annamaria Confaloni, Roberta De Simone

Exp Neurol· September 2004

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Beneficial effects of enriched environment on adolescent rats from stressed pregnancies.
Giovanni Laviola, Monica Rea, Sara Morley-Fletcher, Simonetta Di Carlo, Antonella Bacosi, Roberta De Simone

Eur J Neurosci· September 2004

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