Publications by authors named "Roberta Pelanda"

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Lpar5 regulates the CD8 T-cell response to persistent virus infection by altering exhaustion programming, survival, and NK receptor expression.
Marc A D'Antonio, Brian C Ware, James E DiLisio, Mary Jessamine Michaels, Jacqueline A Turner, Roberta Pelanda

J Immunol· November 2025

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Liver sinusoidal endothelial cells regulate the balance between hepatic immunosuppression and immunosurveillance.
Kimberly N Kremer, Hadeel A Khammash, Anjelica M Miranda, Lauren N Rutt, Shannon M Twardy, Roberta Pelanda

Front Immunol· May 2025

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Maf expression in B cells restricts reactive plasmablast and germinal center B cell expansion.
Sophie Hillion, Anjelica Miranda, Christelle Le Dantec, Marina Boudigou, Laëtitia Le Pottier, Roberta Pelanda

Nat Commun· September 2024

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Regulation of Foxo1 expression is critical for central B cell tolerance and allelic exclusion.
Megan R McCaleb, Anjelica M Miranda, Hadeel A Khammash, Raul M Torres, Roberta Pelanda

Cell Rep· June 2024

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Regulation of CD8 T-cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid.
Raul M Torres, Jacqueline A Turner, Marc D'Antonio, Roberta Pelanda, Kimberly N Kremer

Immunol Rev· August 2023

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Activation and pro-inflammatory cytokine production by unswitched memory B cells during SARS-CoV-2 infection.
Moriah J Castleman, Adriana Luna Santos, Kelsey E Lesteberg, James P Maloney, William J Janssen, Roberta Pelanda

Front Immunol· August 2023

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Lysophosphatidic acid modulates CD8 T cell immunosurveillance and metabolism to impair anti-tumor immunity.
Jacqueline A Turner, Malia A Fredrickson, Marc D'Antonio, Elizabeth Katsnelson, Morgan MacBeth, Roberta Pelanda

Nat Commun· June 2023

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CD19 Is Internalized Together with IgM in Proportion to B Cell Receptor Stimulation and Is Modulated by Phosphatidylinositol 3-Kinase in Bone Marrow Immature B Cells.
Megan R McCaleb, Anjelica M Miranda, Kaysie C Ratliff, Raul M Torres, Roberta Pelanda

Immunohorizons· January 2023

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Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors.
Jordi M Lanis, Matthew S Lewis, Hannah Strassburger, Kristina Larsen, Stacey M Bagby, Roberta Pelanda

J Vis Exp· December 2022

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Cabozantinib sensitizes microsatellite stable colorectal cancer to immune checkpoint blockade by immune modulation in human immune system mouse models.
Julie Lang, Alexis D Leal, Juan A Marín-Jiménez, Sarah J Hartman, Jeremy Shulman, Roberta Pelanda

Front Oncol· November 2022

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Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cells.
Moriah J Castleman, Megan M Stumpf, Nicholas R Therrien, Mia J Smith, Kelsey E Lesteberg, Roberta Pelanda

Front Immunol· September 2022

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SARS-CoV-2 infection relaxes peripheral B cell tolerance.
Moriah J Castleman, Megan M Stumpf, Nicholas R Therrien, Mia J Smith, Kelsey E Lesteberg, Roberta Pelanda

J Exp Med· June 2022

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B-cell intrinsic and extrinsic signals that regulate central tolerance of mouse and human B cells.
Roberta Pelanda, Sarah A Greaves, Thiago Alves da Costa, Lena M Cedrone, Margaret L Campbell

Immunol Rev· May 2022

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Many Achilles' heels of B and T cell tolerance.
Roberta Pelanda, Julie Zikherman

Immunol Rev· May 2022

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Elevated Detection of Dual Antibody B Cells Identifies Lupus Patients With B Cell-Reactive VH4-34 Autoantibodies.
Jacob N Peterson, Susan A Boackle, Sophina H Taitano, Allison Sang, Julie Lang, Roberta Pelanda

Front Immunol· April 2022

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LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation.
Kimberly N Kremer, Alan Buser, Dean Thumkeo, Shuh Narumiya, Jordan Jacobelli, Roberta Pelanda

Proc Natl Acad Sci U S A· April 2022

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Testing Cancer Immunotherapy in a Human Immune System Mouse Model: Correlating Treatment Responses to Human Chimerism, Therapeutic Variables and Immune Cell Phenotypes.
Juan A Marín-Jiménez, Anna Capasso, Matthew S Lewis, Stacey M Bagby, Sarah J Hartman, Roberta Pelanda

Front Immunol· July 2021

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Histone H2A-Reactive B Cells Are Functionally Anergic in Healthy Mice With Potential to Provide Humoral Protection Against HIV-1.
Amanda Agazio, Jennifer Cimons, Kristin M Shotts, Kejun Guo, Mario L Santiago, Roberta Pelanda

Front Immunol· April 2021

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Central human B cell tolerance manifests with a distinctive cell phenotype and is enforced via CXCR4 signaling in hu-mice.
Thiago Alves da Costa, Jacob N Peterson, Julie Lang, Jeremy Shulman, Xiayuan Liang, Roberta Pelanda

Proc Natl Acad Sci U S A· April 2021

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Graft-derived extracellular vesicles transported across subcapsular sinus macrophages elicit B cell alloimmunity after transplantation.
Furong Zeng, Zhizhao Chen, Rao Chen, William J Shufesky, Mohna Bandyopadhyay, Roberta Pelanda

Sci Transl Med· March 2021

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RX-5902, a novel β-catenin modulator, potentiates the efficacy of immune checkpoint inhibitors in preclinical models of triple-negative breast Cancer.
John J Tentler, Julie Lang, Anna Capasso, Deog Joong Kim, Ely Benaim, Roberta Pelanda

BMC Cancer· November 2020

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LPA Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling.
Divij Mathew, Kimberly N Kremer, Pamela Strauch, Gabor Tigyi, Roberta Pelanda

Front Immunol· August 2020

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The development of human immune system mice and their use to study tolerance and autoimmunity.
Thiago Alves da Costa, Julie Lang, Raul M Torres, Roberta Pelanda

J Transl Autoimmun· December 2019

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Humanized immune system mouse models: progress, challenges and opportunities.
Todd M Allen, Michael A Brehm, Sandra Bridges, Stacy Ferguson, Priti Kumar, Roberta Pelanda

Nat Immunol· July 2019

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Active PI3K abrogates central tolerance in high-avidity autoreactive B cells.
Sarah A Greaves, Jacob N Peterson, Pamela Strauch, Raul M Torres, Roberta Pelanda

J Exp Med· May 2019

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