Publications by authors named "Robin Kleiman"

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A community-led initiative to de-risk and advance Parkinson's disease therapeutic targets.
Alexandra Vaiana, Jonathan Behr, Ryan Birol, Cornelis Blauwendraat, Bradford Casey, Robin Kleiman

NPJ Parkinsons Dis· June 2025

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Cis-regulatory elements driving motor neuron-selective viral payload expression within the mammalian spinal cord.
M Aurel Nagy, Spencer Price, Kristina Wang, Stanley Gill, Erika Ren, Robin Kleiman

Proc Natl Acad Sci U S A· December 2024

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Cis-regulatory elements driving motor neuron-restricted viral payload expression within the mammalian spinal cord.
M Aurel Nagy, Spencer Price, Kristina Wang, Stanley P Gill, Erika Ren, Robin Kleiman

bioRxiv· September 2024

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16p13.11 deletion variants associated with neuropsychiatric disorders cause morphological and synaptic changes in induced pluripotent stem cell-derived neurons.
Elizabeth D Buttermore, Nickesha C Anderson, Pin-Fang Chen, Nina R Makhortova, Kristina H Kim, Robin J Kleiman

Front Psychiatry· November 2022

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Gene-based therapeutics for rare genetic neurodevelopmental psychiatric disorders.
Beverly L Davidson, Guangping Gao, Elizabeth Berry-Kravis, Allison M Bradbury, Carsten Bönnemann, Robin J Kleiman

Mol Ther· July 2022

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Endothelial p.R183Q Increases ANGPT2 (Angiopoietin-2) and Drives Formation of Enlarged Blood Vessels.
Lan Huang, Colette Bichsel, Alexis L Norris, Jeremy Thorpe, Jonathan Pevsner, Robin J Kleiman

Arterioscler Thromb Vasc Biol· January 2022

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Human inducible pluripotent stem cells: Realization of initial promise in drug discovery.
Robin J Kleiman, Sandra J Engle

Cell Stem Cell· September 2021

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Generation and characterization of human induced pluripotent stem cells (iPSCs) from three male and three female patients with CDKL5 Deficiency Disorder (CDD).
Pin-Fang Chen, Teresa Chen, Taylor E Forman, Amanda C Swanson, Benjamin O'Kelly, Robin Kleiman

Stem Cell Res· May 2021

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Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia.
Alessia Di Nardo, Isadora Lenoël, Kellen D Winden, Alina Rühmkorf, Meera E Modi, Robin J Kleiman

Cell Rep· June 2020

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How to develop therapeutic and translational research collaborations with industry.
Robin J Kleiman, Michael D Ehlers

Mol Biol Cell· October 2019

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A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport.
Evgeny Shlevkov, Himanish Basu, Mark-Anthony Bray, Zheng Sun, Wei Wei, Robin J Kleiman

Cell Rep· September 2019

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Postmortem transcriptional profiling reveals widespread increase in inflammation in schizophrenia: a comparison of prefrontal cortex, striatum, and hippocampus among matched tetrads of controls with subjects diagnosed with schizophrenia, bipolar or major depressive disorder.
Thomas A Lanz, Veronica Reinhart, Mark J Sheehan, Stacey J Sukoff Rizzo, Susan E Bove, Robin J Kleiman

Transl Psychiatry· May 2019

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Best Practices for Translational Disease Modeling Using Human iPSC-Derived Neurons.
Sandra J Engle, Laura Blaha, Robin J Kleiman

Neuron· November 2018

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and compound heterozygous mutations in a child with autism spectrum disorder, episodic fatigue and somnolence, and muckle-wells syndrome.
Alcy Torres, Catherine A Brownstein, Sahil K Tembulkar, Kelsey Graber, Casie Genetti, Robin J Kleiman

Mol Genet Metab Rep· September 2018

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Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.
Christopher J Helal, Eric P Arnold, Tracey L Boyden, Cheng Chang, Thomas A Chappie, Robin J Kleiman

J Med Chem· April 2018

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Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate.
Christopher J Helal, Eric Arnold, Tracey Boyden, Cheng Chang, Thomas A Chappie, Robin J Kleiman

J Med Chem· February 2018

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Translating genetic and preclinical findings into autism therapies.
Maria Chahrour, Robin J Kleiman, M Chiara Manzini

Dialogues Clin Neurosci· December 2017

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Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.
Christopher J Helal, Eric P Arnold, Tracey L Boyden, Cheng Chang, Thomas A Chappie, Robin J Kleiman

J Med Chem· July 2017

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Current Perspectives in Autism Spectrum Disorder: From Genes to Therapy.
Maria Chahrour, Brian J O'Roak, Emanuela Santini, Rodney C Samaco, Robin J Kleiman

J Neurosci· November 2016

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A novel de novo mutation in ATP1A3 and childhood-onset schizophrenia.
Niklas Smedemark-Margulies, Catherine A Brownstein, Sigella Vargas, Sahil K Tembulkar, Meghan C Towne, Robin J Kleiman

Cold Spring Harb Mol Case Stud· September 2016

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Overlapping 16p13.11 deletion and gain of copies variations associated with childhood onset psychosis include genes with mechanistic implications for autism associated pathways: Two case reports.
Catherine A Brownstein, Robin J Kleiman, Elizabeth C Engle, Meghan C Towne, Eugene J D'Angelo

Am J Med Genet A· May 2016

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Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis.
Jeremy R Egbert, Tracy F Uliasz, Leia C Shuhaibar, Andreas Geerts, Frank Wunder, Robin J Kleiman

Biol Reprod· May 2016

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Data gaps limit the translational potential of preclinical research.
Robin J Kleiman, Michael D Ehlers

Sci Transl Med· January 2016

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Evaluation of TrkB and BDNF transcripts in prefrontal cortex, hippocampus, and striatum from subjects with schizophrenia, bipolar disorder, and major depressive disorder.
Veronica Reinhart, Susan E Bove, Dmitri Volfson, David A Lewis, Robin J Kleiman

Neurobiol Dis· May 2015

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Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain.
Michy P Kelly, Wendy Adamowicz, Susan Bove, Alexander J Hartman, Abigail Mariga, Robin J Kleiman

Cell Signal· February 2014

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