Publications by authors named "Rod Chalk"

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Crystal structure of fatty acid thioesterase A bound by 129 fragments provides diverse development opportunities.
Ekaterina Kot, Matteo Paolo Ferla, Patricia Helen Hollinshead, Charles William Ernest Tomlinson, Daren Fearon, Rod Chalk

Pest Manag Sci· January 2026

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"Design principles of a membrane-spanning ubiquitin ligase".
Carys Williams, Laura M Nocka, George Hedger, Pragya Parashara, Els Pardon, Rod Chalk

bioRxiv· September 2025

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Structural basis of the mechanism and inhibition of a human ceramide synthase.
Tomas C Pascoa, Ashley C W Pike, Christofer S Tautermann, Gamma Chi, Michael Traub, Rod Chalk

Nat Struct Mol Biol· March 2025

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Covalent Inhibitors of KEAP1 with Exquisite Selectivity.
Imre Fejes, Piroska Markacz, Janos Tatai, Monika Rudas, Petra Dunkel, Rod Chalk

J Med Chem· December 2024

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BTB domain mutations perturbing KCTD15 oligomerisation cause a distinctive frontonasal dysplasia syndrome.
Kerry A Miller, David A Cruz Walma, Daniel M Pinkas, Rebecca S Tooze, Joshua C Bufton, Rod Chalk

J Med Genet· April 2024

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Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.
William J Bradshaw, Emma C Kennedy, Tiago Moreira, Luke A Smith, Rod Chalk

Structure· April 2024

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Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.
Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, Rod Chalk

PLoS One· February 2024

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Structural characterization of human urea transporters UT-A and UT-B and their inhibition.
Gamma Chi, Larissa Dietz, Haiping Tang, Matthew Snee, Andreea Scacioc, Rod Chalk

Sci Adv· September 2023

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Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.
Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, Rod Chalk

bioRxiv· July 2023

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Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease.
Andre Schutzer Godoy, Aline Minalli Nakamura, Alice Douangamath, Yun Song, Gabriela Dias Noske, Rod Chalk

Nucleic Acids Res· June 2023

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An in-solution snapshot of SARS-COV-2 main protease maturation process and inhibition.
Gabriela Dias Noske, Yun Song, Rafaela Sachetto Fernandes, Rod Chalk, Haitem Elmassoudi

Nat Commun· March 2023

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Reducing hyperglucagonaemia in type 2 diabetes using low-dose glibenclamide: Results of the LEGEND-A pilot study.
Ioannis I Spiliotis, Rod Chalk, Stephen Gough, Patrik Rorsman

Diabetes Obes Metab· August 2022

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Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells.
Ole Tietz, Fernando Cortezon-Tamarit, Rod Chalk, Sarah Able, Katherine A Vallis

Nat Chem· March 2022

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Structural Insights into Notum Covalent Inhibition.
Yuguang Zhao, Fredrik Svensson, David Steadman, Sarah Frew, Amy Monaghan, Rod Chalk

J Med Chem· August 2021

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Identification, mapping and relative quantitation of SARS-CoV-2 Spike glycopeptides by Mass-Retention Time Fingerprinting.
Rod Chalk, William E P Greenland, Tiago Moreira, Jesse Coker, Shubhashish M M Mukhopadhyay

Commun Biol· August 2021

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An In-labelled bis-ruthenium(ii) dipyridophenazine theranostic complex: mismatch DNA binding and selective radiotoxicity towards MMR-deficient cancer cells.
Martin R Gill, Michael G Walker, Sarah Able, Ole Tietz, Abirami Lakshminarayanan, Rod Chalk

Chem Sci· September 2020

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Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity.
Conor McClenaghan, Yan Huang, Zihan Yan, Theresa M Harter, Carmen M Halabi, Rod Chalk

J Clin Invest· March 2020

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Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.
Yin Yao Dong, Hua Wang, Ashley C W Pike, Stephen A Cochrane, Sadra Hamedzadeh, Rod Chalk

Cell· November 2018

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Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.
D Sean Froese, Jolanta Kopec, Elzbieta Rembeza, Gustavo Arruda Bezerra, Anselm Erich Oberholzer, Rod Chalk

Nat Commun· June 2018

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Mass Spectrometric Analysis of Proteins.
Rod Chalk

Methods Mol Biol· February 2018

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Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Daniel M Pinkas, Caroline E Sanvitale, Joshua C Bufton, Fiona J Sorrell, Nicolae Solcan, Rod Chalk

Biochem J· November 2017

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Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).
Mariana Grieben, Ashley C W Pike, Chitra A Shintre, Elisa Venturi, Sam El-Ajouz, Rod Chalk

Nat Struct Mol Biol· February 2017

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Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase.
Thomas J McCorvie, Jolanta Kopec, Angel L Pey, Fiona Fitzpatrick, Dipali Patel, Rod Chalk

Hum Mol Genet· June 2016

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Structural Insights into the MMACHC-MMADHC Protein Complex Involved in Vitamin B12 Trafficking.
D Sean Froese, Jolanta Kopec, Fiona Fitzpatrick, Marion Schuller, Thomas J McCorvie, Rod Chalk

J Biol Chem· December 2015

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Serum indoleamine 2,3-dioxygenase activity is associated with reduced immunogenicity following vaccination with MVA85A.
Rachel Tanner, Kristina Kakalacheva, Ellen Miller, Ansar A Pathan, Rod Chalk

BMC Infect Dis· December 2014

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