Publications by authors named "Roddy Large"

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Regulation of P2X1 receptors by modulators of the cAMP effectors PKA and EPAC.
Zhihui Fong, Caoimhín S Griffin, Roddy J Large, Mark A Hollywood, Keith D Thornbury

Proc Natl Acad Sci U S A· September 2021

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LINGO1 is a regulatory subunit of large conductance, Ca-activated potassium channels.
Srikanth Dudem, Roddy J Large, Shruti Kulkarni, Heather McClafferty, Irina G Tikhonova

Proc Natl Acad Sci U S A· January 2020

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Inhibitory effects of openers of large-conductance Ca-activated K channels on agonist-induced phasic contractions in rabbit and mouse bronchial smooth muscle.
Eamonn Bradley, Roddy J Large, Viktoriia Volodymyrivna Bihun, Nicolas D Mullins, Mark A Hollywood

Am J Physiol Cell Physiol· December 2018

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Effects of new-generation TMEM16A inhibitors on calcium-activated chloride currents in rabbit urethral interstitial cells of Cajal.
Stephen Fedigan, Eamonn Bradley, Timothy Webb, Roddy J Large, Mark A Hollywood

Pflugers Arch· November 2017

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The role of Ca-activated Cl current in tone generation in the rabbit corpus cavernosum.
Karen I Hannigan, Caoimhin S Griffin, Roddy J Large, Gerard P Sergeant, Mark A Hollywood

Am J Physiol Cell Physiol· November 2017

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Differential efficacy of GoSlo-SR compounds on BKα and BKαγ channels.
Aravind S Kshatri, Qin Li, Jiusheng Yan, Roddy J Large, Gerard P Sergeant

Channels (Austin)· January 2017

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The role of Ca(2+) influx in spontaneous Ca(2+) wave propagation in interstitial cells of Cajal from the rabbit urethra.
Bernard T Drumm, Roddy J Large, Mark A Hollywood, Keith D Thornbury, Salah A Baker

J Physiol· August 2015

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Molecular mechanisms underlying the effect of the novel BK channel opener GoSlo: involvement of the S4/S5 linker and the S6 segment.
Timothy I Webb, Aravind Singh Kshatri, Roddy J Large, Adebola Morayo Akande, Subhrangsu Roy

Proc Natl Acad Sci U S A· February 2015

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Development of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels.
Subhrangsu Roy, Roddy J Large, Adebola Morayo Akande, Aravind Kshatri, Tim I Webb

Eur J Med Chem· March 2014

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Mechanisms underlying activation of transient BK current in rabbit urethral smooth muscle cells and its modulation by IP3-generating agonists.
Barry D Kyle, Eamonn Bradley, Roddy Large, Gerard P Sergeant, Noel G McHale

Am J Physiol Cell Physiol· September 2013

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Structure-activity relationships of a novel group of large-conductance Ca(2+)-activated K(+) (BK) channel modulators: the GoSlo-SR family.
Subhrangsu Roy, Adebola Morayo Akande, Roddy J Large, Tim I Webb, Costin Camarasu

ChemMedChem· October 2012

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Voltage-dependent Ca2+ currents contribute to spontaneous Ca2+ waves in rabbit corpus cavernosum myocytes.
Conor McCloskey, Victoria Cagney, Roddy Large, Mark Hollywood, Gerard Sergeant

J Sex Med· November 2009

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Microarray comparison of normal and W/Wv mice in the gastric fundus indicates a supersensitive phenotype.
Gerard P Sergeant, Roddy J Large, Elizabeth A H Beckett, Cathrine M McGeough, Sean M Ward

Physiol Genomics· October 2002

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