Publications by authors named "Roderick A Stegeman"

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Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Jerry H Houl, Zu Ye, Chris A Brosey, Lakshitha P F Balapiti-Modarage, Sarita Namjoshi, Roderick A Stegeman

Nat Commun· December 2019

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Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor.
Christopher A Nelson, Craig B Wilen, Ya-Nan Dai, Robert C Orchard, Arthur S Kim, Roderick A Stegeman

Proc Natl Acad Sci U S A· September 2018

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A quantitative assay reveals ligand specificity of the DNA scaffold repair protein XRCC1 and efficient disassembly of complexes of XRCC1 and the poly(ADP-ribose) polymerase 1 by poly(ADP-ribose) glycohydrolase.
In-Kwon Kim, Roderick A Stegeman, Chris A Brosey, Tom Ellenberger

J Biol Chem· February 2015

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Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element.
In-Kwon Kim, James R Kiefer, Chris M W Ho, Roderick A Stegeman, Scott Classen

Nat Struct Mol Biol· May 2012

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Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804.
Li Xing, Huey S Shieh, Shaun R Selness, Rajesh V Devraj, John K Walker, Roderick A Stegeman

Biochemistry· July 2009

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2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: design and synthesis of a potent and isoform selective PKC-zeta inhibitor.
John I Trujillo, James R Kiefer, Wei Huang, Atli Thorarensen, Li Xing, Roderick A Stegeman

Bioorg Med Chem Lett· February 2009

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Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa.
Barbara A Schweitzer, William L Neumann, Hayat K Rahman, Carrie L Kusturin, Kirby R Sample, Roderick A Stegeman

Bioorg Med Chem Lett· June 2005

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Synthesis and X-ray crystal structures of substituted fluorobenzene and benzoquinone inhibitors of the tissue factor VIIa complex.
John J Parlow, Ravi G Kurumbail, Roderick A Stegeman, Anna M Stevens, William C Stallings

Bioorg Med Chem Lett· November 2003

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Design, synthesis, and crystal structure of selective 2-pyridone tissue factor VIIa inhibitors.
John J Parlow, Ravi G Kurumbail, Roderick A Stegeman, Anna M Stevens, William C Stallings

J Med Chem· October 2003

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Polymer-assisted solution-phase library synthesis and crystal structure of alpha-ketothiazoles as tissue factor VIIa inhibitors.
John J Parlow, Thomas A Dice, Rhonda M Lachance, Thomas J Girard, Anna M Stevens, Roderick A Stegeman

J Med Chem· September 2003

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Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex.
John J Parlow, Brenda L Case, Thomas A Dice, Ricky L Fenton, Michael J Hayes, Roderick A Stegeman

J Med Chem· September 2003

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Synthesis and crystal structures of substituted benzenes and benzoquinones as tissue factor VIIa inhibitors.
John J Parlow, Anna M Stevens, Roderick A Stegeman, William C Stallings, Ravi G Kurumbail

J Med Chem· September 2003

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Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex.
Michael S South, Brenda L Case, Rhonda S Wood, Darin E Jones, Michael J Hayes, Roderick A Stegeman

Bioorg Med Chem Lett· July 2003

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Polymer-assisted solution-phase (PASP) parallel synthesis of an alpha-ketothiazole library as tissue factor VIIa inhibitors.
Michael S South, Thomas A Dice, Thomas J Girard, Rhonda M Lachance, Anna M Stevens, Roderick A Stegeman

Bioorg Med Chem Lett· July 2003

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