Publications by authors named "Rodney Rouse"

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Absolute quantitation of neopterin as an endogenous pharmacodynamic Biomarker: The successful method development, validation, and use of a surrogate matrix for clinical sample analysis.
Ryan De Palma, Murali Matta, Jeffry Florian, Vikram Patel, Rodney Rouse

Anal Biochem· September 2025

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Development and validation of a high-throughput LC-MS/MS bioanalytical method for the simultaneous quantification of cannabidiol and metabolites in human plasma.
Ryan De Palma, Murali K Matta, Vikram Patel, Jeffry Florian, David G Strauss, Rodney Rouse

J Chromatogr B Analyt Technol Biomed Life Sci· September 2025

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Cannabidiol and Liver Enzyme Level Elevations in Healthy Adults: A Randomized Clinical Trial.
Jeffry Florian, Pablo Salcedo, Keith Burkhart, Aanchal Shah, Lakshmi Manasa S Chekka, Rodney Rouse

JAMA Intern Med· September 2025

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Effect of midazolam co-administered with oxycodone on ventilation: a randomised clinical trial in healthy volunteers.
Victoria Gershuny, Jeffry Florian, Rutger van der Schrier, Michael C Davis, Pablo Salcedo, Rodney Rouse

Br J Anaesth· April 2025

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Advancing alternative methods to reduce animal testing.
Chad P Nelson, Paul Brown, Suzanne Fitzpatrick, Kevin A Ford, Paul C Howard, Rodney Rouse

Science· November 2024

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A metagenomic analysis for combination therapy of multiple classes of antibiotics on the prevention of the spread of antibiotic-resistant genes.
Matthew Igo, Lei Xu, Ashok Krishna, Sharron Stewart, Lin Xu, Rodney Rouse

Gut Microbes· December 2023

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A Bioanalytical Method for Quantification of N-nitrosodimethylamine (NDMA) in Human Plasma and Urine with Different Meals and following Administration of Ranitidine.
Ryan De Palma, Vikram Patel, Jeffry Florian, David Keire, Daniela Selaya, Rodney Rouse

J Pharm Sci· May 2023

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New science, drug regulation, and emergent public health issues: The work of FDA's division of applied regulatory science.
Kimberly Chiu, Rebecca Racz, Keith Burkhart, Jeffry Florian, Kevin Ford, Rodney Rouse

Front Med (Lausanne)· January 2023

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Determination of five positive control drugs in hERG external solution (buffer) by LC-MS/MS to support in vitro hERG assay as recommended by ICH S7B.
Tamara I King, Amruta Indapurkar, Isra Tariq, Ryan DePalma, Sabyasachy Mistry, Rodney Rouse

J Pharmacol Toxicol Methods· November 2022

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Calibration and Validation of a Mechanistic COVID-19 Model for Translational Quantitative Systems Pharmacology - A Proof-of-Concept Model Development for Remdesivir.
Mohammadreza Samieegohar, James L Weaver, Kristina E Howard, Anik Chaturbedi, John Mann, Rodney Rouse

Clin Pharmacol Ther· October 2022

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Effect of Paroxetine or Quetiapine Combined With Oxycodone vs Oxycodone Alone on Ventilation During Hypercapnia: A Randomized Clinical Trial.
Jeffry Florian, Rutger van der Schrier, Victoria Gershuny, Michael C Davis, Celine Wang, Rodney Rouse

JAMA· October 2022

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Effects of sedative psychotropic drugs combined with oxycodone on respiratory depression in the rat.
Lin Xu, Ashok Krishna, Sharron Stewart, Katherine Shea, Rebecca Racz, Rodney Rouse

Clin Transl Sci· November 2021

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Effect of Oral Ranitidine on Urinary Excretion of N-Nitrosodimethylamine (NDMA): A Randomized Clinical Trial.
Jeffry Florian, Murali K Matta, Ryan DePalma, Victoria Gershuny, Vikram Patel, Rodney Rouse

JAMA· July 2021

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Emergence of nosocomial associated opportunistic pathogens in the gut microbiome after antibiotic treatment.
Isaac Raplee, Lacey Walker, Lei Xu, Anil Surathu, Ashok Chockalingam, Rodney Rouse

Antimicrob Resist Infect Control· February 2021

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The effect of antibiotics on the gut microbiome: a metagenomics analysis of microbial shift and gut antibiotic resistance in antibiotic treated mice.
Lei Xu, Anil Surathu, Isaac Raplee, Ashok Chockalingam, Sharron Stewart, Rodney Rouse

BMC Genomics· March 2020

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Quantitative analysis of underivatized 17 β-estradiol using a high-throughput LC-MS/MS assay - Application to support a pharmacokinetic study in ovariectomized guinea pigs.
Adarsh Gandhi, Murali K Matta, Sharron Stewart, Ashok Chockalingam, Alan Knapton, Rodney Rouse

J Pharm Biomed Anal· January 2020

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Advancing Biosimilar Development Using Pharmacodynamic Biomarkers in Clinical Pharmacology Studies.
Junyi Li, Jeffry Florian, Elizabeth Campbell, Sarah J Schrieber, Jane P F Bai, Rodney L Rouse

Clin Pharmacol Ther· January 2020

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A high-throughput bioanalytical assay to support pharmacokinetic interaction study of oxycodone and diazepam in Sprague Dawley rats.
Nageswara R Pilli, Suresh Narayanasamy, Lin Xu, Ashok Chockalingam, Katherine I Shea, Rodney Rouse

RSC Adv· January 2020

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Developing an animal model to detect drug-drug interactions impacting drug-induced respiratory depression.
Lin Xu, Ashok Chockalingam, Sharron Stewart, Katherine Shea, Murali K Matta, Rodney Rouse

Toxicol Rep· January 2020

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Detection of Reg3γ by Immunohistochemistry in Cerulein-Induced Model of Acute Pancreatic Injury in Mice and Rats.
Katherine Shea, Rodney Rouse

Pancreas· September 2019

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Evaluation of Immunocompetent Urinary Tract Infected Balb/C Mouse Model For the Study of Antibiotic Resistance Development Using CFT073 Infection.
Ashok Chockalingam, Sharron Stewart, Lin Xu, Adarsh Gandhi, Murali K Matta, Rodney Rouse

Antibiotics (Basel)· September 2019

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Protocol for evaluation of topical ophthalmic drug products in different compartments of fresh eye tissues in a rabbit model.
Ashok Chockalingam, Lin Xu, Sharron Stewart, Maxime LeMerdy, Eleftheria Tsakalozou, Rodney Rouse

J Pharmacol Toxicol Methods· July 2019

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An alternating polarity switching assay for quantification of oxycodone and topiramate: An application of LC-MS/MS method in support to PK/PD study in rodents.
Suresh Narayanasamy, Nageswara R Pilli, Lin Xu, Ashok Chockalingam, Katherine I Shea, Rodney Rouse

J Chromatogr B Analyt Technol Biomed Life Sci· June 2019

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Application of Mechanistic Ocular Absorption Modeling and Simulation to Understand the Impact of Formulation Properties on Ophthalmic Bioavailability in Rabbits: a Case Study Using Dexamethasone Suspension.
Maxime Le Merdy, Jianghong Fan, Michael B Bolger, Viera Lukacova, Jessica Spires, Rodney Rouse

AAPS J· May 2019

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Biomarkers of drug-induced acute kidney injury: a regulatory perspective.
Melanie Blank, Aliza Thompson, Elizabeth Hausner, Rodney Rouse

Expert Opin Drug Metab Toxicol· September 2018

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