Publications by authors named "Roelof Smit"

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Complex genetic effects linked to plasma protein abundance in the UK Biobank.
Arnor I Sigurdsson, Justus F Gräf, Zhiyu Yang, Kirstine Ravn, Jonas Meisner, Roelof A J Smit

Nat Commun· December 2025

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Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities.
Nathalie Chami, Zhe Wang, Victor Svenstrup, Virginia Diez Obrero, Daiane Hemerich, Roelof A J Smit

Nat Med· November 2025

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Polygenic risk score for type 2 diabetes shows context-dependent effects across populations.
Boya Guo, Yanwei Cai, Daeeun Kim, Roelof A J Smit, Zhe Wang

Nat Commun· October 2025

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Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease.
Daeeun Kim, Heather M Highland, Roelof A J Smit, Micah R Hysong, Victoria L Buchanan

Genome Med· October 2025

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Polygenic prediction of body mass index and obesity through the life course and across ancestries.
Roelof A J Smit, Kaitlin H Wade, Qin Hui, Joshua D Arias, Xianyong Yin, Albert V Smith, Jennifer A Smith, J Gustav Smith

Nat Med· September 2025

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Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals.
Margaret Sunitha Selvaraj, Xihao Li, Zilin Li, Eric Van Buren, Sara Haidermota, Roelof A J Smit, Jennifer A Smith

Genome Biol· September 2025

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Genome-wide association study provides novel insight into the genetic architecture of severe obesity.
Mohanraj Krishnan, Mohammad Yaser Anwar, Anne E Justice, Geetha Chittoor, Hung-Hsin Chen, Roelof A J Smit, Jennifer A Smith

PLoS Genet· September 2025

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Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery.
Jakob German, Mattia Cordioli, Veronica Tozzo, Sarah Urbut, Kadri Arumäe, Roelof A J Smit

Nat Med· July 2025

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Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases.
Carolina Roselli, Ida Surakka, Morten S Olesen, Gardar Sveinbjornsson, Nicholas A Marston, Roelof A J Smit, Jennifer A Smith, Nicholas L Smith, J Gustav Smith

Nat Genet· March 2025

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Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk.
Seung Hoan Choi, Sean J Jurgens, Ling Xiao, Matthew C Hill, Christopher M Haggerty, Jonathan D Smith, Nicholas L Smith, Roelof A J Smit, J Gustav Smith

Nat Genet· March 2025

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Type 2 diabetes polygenic risk score demonstrates context-dependent effects and associations with type 2 diabetes-related risk factors and complications across diverse populations.
Boya Guo, Yanwei Cai, Daeeun Kim, Roelof A J Smit, Zhe Wang

medRxiv· February 2025

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Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities.
Nathalie Chami, Zhe Wang, Victor Svenstrup, Virginia Diez Obrero, Daiane Hemerich, Roelof A J Smit

medRxiv· February 2025

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Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery: a multi-ancestry study in 10 960 individuals from 9 biobanks.
Jakob German, Mattia Cordioli, Veronica Tozzo, Sarah Urbut, Kadri Arumäe, Roelof A J Smit

medRxiv· January 2025

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Association Between Low Sex Hormone-Binding Globulin and Increased Risk of Type 2 Diabetes Is Mediated by Increased Visceral and Liver Fat: Results From Observational and Mendelian Randomization Analyses.
Theresa A Stangl, Chantal M Wiepjes, Roelof A J Smit, Astrid van Hylckama Vlieg, Hildo J Lamb

Diabetes· November 2024

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Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations.
Niall J Lennon, Leah C Kottyan, Christopher Kachulis, Noura S Abul-Husn, Josh Arias, Roelof A J Smit, Johanna L Smith

Nat Med· February 2024

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Association between pain intensity and depressive symptoms in community-dwelling adults: longitudinal findings from the Survey of Health, Ageing and Retirement in Europe (SHARE).
Giulia Ogliari, Jesper Ryg, Karen Andersen-Ranberg, Lasse Lybecker Scheel-Hincke, Jemima T Collins, Roelof A J Smit

Eur Geriatr Med· October 2023

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Assessing efficiency of fine-mapping obesity-associated variants through leveraging ancestry architecture and functional annotation using PAGE and UKBB cohorts.
Mohammad Yaser Anwar, Mariaelisa Graff, Heather M Highland, Roelof Smit, Zhe Wang

Hum Genet· October 2023

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Selection, optimization, and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse populations.
Niall J Lennon, Leah C Kottyan, Christopher Kachulis, Noura Abul-Husn, Josh Arias, Roelof Smit, Johanna Smith

medRxiv· June 2023

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The association between leptin and subclinical cardiovascular disease explained by body fat: Observational and Mendelian randomization analyses.
Tim Christen, Renée de Mutsert, Roelof Aj Smit, Ko Willems van Dijk, Hildo J Lamb

Nutr Metab Cardiovasc Dis· May 2023

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Effect of tissue-grouped regulatory variants associated to type 2 diabetes in related secondary outcomes.
Daiane Hemerich, Roelof A J Smit, Michael Preuss, Lauren Stalbow, Sander W van der Laan

Sci Rep· March 2023

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The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations.
Lauren A Stalbow, Michael H Preuss, Roelof A J Smit, Nathalie Chami, Lise Bjørkhaug

Diabetologia· January 2023

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Erratum: Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium.
Lindsay Fernández-Rhodes, Mariaelisa Graff, Victoria L Buchanan, Anne E Justice, Heather M Highland, Roelof A J Smit, Jennifer A Smith

HGG Adv· January 2023

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A saturated map of common genetic variants associated with human height.
Loïc Yengo, Sailaja Vedantam, Eirini Marouli, Julia Sidorenko, Eric Bartell, Roelof A J Smit, Albert V Smith, Jennifer A Smith, J Gustav Smith

Nature· October 2022

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A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood.
Nuzulul Kurniansyah, Matthew O Goodman, Tanika N Kelly, Tali Elfassy, Kerri L Wiggins, Jennifer A Smith, Roelof A J Smit

Nat Commun· June 2022

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Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium.
Lindsay Fernández-Rhodes, Mariaelisa Graff, Victoria L Buchanan, Anne E Justice, Heather M Highland, Roelof A J Smit, Jennifer A Smith

HGG Adv· April 2022

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